6 European Projects Found
Searched on 125080 European Projects
FINISHED
Vaccination In Atherosclerosis (VIA)
Start date: Dec 1, 2013, End date: Nov 30, 2018,
"Cardiovascular disease (CVD) is still a leading cause of death in the European Union (EU) accounting for nearly half of all deaths in Europe (48%). In addition, CVD complications lead to a vast number of hospitalizations and thus to a great burden of health care costs in the EU. Atherosclerosis and its final complication, plaque rupture and subsequent infarct in heart or brain, is the main underl ...
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12
Partners Participants
FINISHED
Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer (CAM-PAC)
Start date: Nov 1, 2013, End date: Oct 31, 2018,
Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from di ...
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18
Partners Participants
FINISHED
Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL)
Start date: Oct 1, 2013, End date: Sep 30, 2018,
"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth char ...
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19
Partners Participants
FINISHED
Identification and validation of novel pharmaceutical drug targets for cardiovascular disease (CARTARDIS)
Start date: Oct 1, 2013, End date: Sep 30, 2017,
"Cardiovascular disease (CVD) is one of the major diseases in Europe and the Western world, killing over 2 million people per year in Europe alone and is the foremost cause of premature mortality and disability-adjusted life years, representing an annual economic cost of ∼€ 192 billion in direct and indirect healthcare expenses. The available therapies are insufficient to fulfill the need. The int ...
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13
Partners Participants
FINISHED
Development of very promising humanized therapeutic mAbs efficiently neutralizing a novel immunosuppressive pathway involved in a wide range of cancers (TumAdoR)
Start date: Sep 1, 2013, End date: Aug 31, 2017,
Studies have demonstrated the importance of CD73 in the spread of cancer. Overexpressed in numerous cancer types, this enzyme leads to the production of high amounts of extracellular Adenosine, creating an immunosuppressive microenvironment, and contributing to tumor proliferation and dissemination. Neutralizing its activity represents a highly potent and innovative therapy.Following on the recent ...
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8
Partners Participants
FINISHED
Identification and therapeutic targeting of common arrhythmia trigger mechanisms (EUTRIGTREAT)
Start date: Oct 1, 2009, End date: Mar 31, 2015,
Arrhythmias are common manifestations of heart disease which frequently cause sudden cardiac death (SCD) or other devastating health problems. In Europe, prevention of SCD by device and drug therapy is expensive and increasingly strains public health resources due to a growing population at risk. However, identification of patients at increased risk for SCD is ineffective, and SCD prevention strat ...
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