Search for European Projects

23 European Projects Found

Searched on 125080 European Projects

 FINISHED 

A Phase Ib/II study of MEK1/2 inhibitor PD-0325901 or MEK-162 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients (MERCURIC)

Start date: Dec 1, 2013, End date: Nov 30, 2020,

Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omi ...
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 13

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Evidence-based ICT tools for weight loss maintenance (NoHoW)

Start date: Mar 1, 2015, End date: Feb 29, 2020,

Most adults who try to lose weight fail to maintain it. Obesity is a key economic and healthcare challenge for Europe. Effective interventions and commercial programmes for weight loss are widely available, but most people re-gain their lost weight. Currently few comprehensive solutions exist to help Europeans manage weight loss maintenance (WLM).Current research suggests the most promising eviden ...
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 16

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Novel Stromal Cell Therapy for Diabetic Kidney Disease (NEPHSTROM)

Start date: May 1, 2015, End date: Apr 30, 2019,

Type 2 diabetes will affect >500 million adults by 2040 and its secondary complications will generate enormous socioeconomic costs - in particular, diabetic kidney disease (DKD), which is already the most common cause of chronic kidney disease. DKD is associated with greatly increased mortality and frequently progresses to end stage renal failure. Pharmacotherapy, dialysis and transplantation repr ...
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 12

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Adverse Immune Signatures and their Prevention in Corneal Transplantation (VISICORT)

Start date: Apr 1, 2014, End date: Mar 31, 2019,

"Immune system response is the most complex barrier to long-term success of tissue transplants/implants from allogeneic and bio-artificial sources. While newly developed tissue transplant procedures are not yet performed frequently enough for robust analysis of adverse immune responses in humans, corneal transplantation (CT) is a well-established allogeneic tissue transplant with >100,000 full- an ...
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 12

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Development of closed, scalable and AUTOmated robotic systems for therapeutic STEM cell manufacturing: aseptic systems from “Donor-to-Patient” (AUTOSTEM)

Start date: Jan 1, 2016, End date: Dec 31, 2018,

AUTOSTEM will develop closed, scaleable and automated systems for therapeutic cell manufacture. The project vision is a donor-to-patient system where all aspects of processing, from tissue harvest to patient delivery are fully closed and aseptic. The process will involve new methods of biological cell selection from marrow, fat or other tissues, bioreactors to achieve scale and media formulations ...
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 10

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Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis (ADIPOA2)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

Osteoarthritis (OA) is an incurable disease that has evaded pharmacological interference, biologic therapy or surgical intervention to prevent disease progression. Currently, OA is designated the 11th highest contributor (of 291 diseases) of global disability. In the absence of effective treatment options, cellular therapies using mesenchymal stem/stromal cells (MSCs) have emerged as potential can ...
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 20

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The Novel Materials Discovery Laboratory (NoMaD)

Start date: Nov 1, 2015, End date: Oct 31, 2018,

Essentially every new commercial product, be they smart phones, solar cells, batteries, transport technology, artificial hips, etc., depends on improved or even novel materials. Computational materials science is increasingly influential as a method to identify such critical materials for both R&D. Enormous amounts of data, precious but heterogeneous and difficult to access or utilise, are already ...
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 11

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Social innovation to improve physical activity and sedentary behaviour through elite European football clubs: European Fans in Training (EuroFIT)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Concept and aim: 20 million fans attend top division football games each week and many more watch on TV. Our social innovation is to attract people to lifestyle change through the personal connection and loyalty to the club they support. Our aim is to use this social innovation to change physical activity and sedentary behaviour, specially targeting low-SES groups, and men as well as women. EuroFI ...
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 13

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PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood (PANCARELIFE)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
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 19

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MEsenchymal stem cells to Reduce Liver INflammation (MERLIN)

Start date: Feb 1, 2014, End date: Jan 31, 2018,

"Prevalence of liver disease is c6% (29 million people) in the EU with mortality rates from chronic liver diseases estimated at 14.3 per 100.000 in the EU-25 in 2004. Most liver diseases have a significant inflammatory component that underpins liver damage and fibrogenesis, yet current therapies have limited effectiveness. Safe novel anti-inflammatory therapies would satisfy a large unmet need for ...
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 9

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Security System for language and image analysis (Slandail)

Start date: Apr 1, 2014, End date: Mar 31, 2017,

Project Slándáil will demonstrate a cost-effective and ethically-correct way in which social media information can be used by an emergency management system. The social media landscape consists of a range of digitized documents in a variety of formats, updated by a diverse and geographically distributed people and organisations. During an emergency, authorities use websites and the population, emp ...
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 12

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Repair of Diabetic Damage by Stromal Cell Administration (REDDSTAR)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

50 million diabetic EU citizens are using approved anti-diabetic agents to control their glycaemia. However, suboptimal glycemic control leads to 6 progressive diabetic complications, namely: nephropathy, retinopathy, cardiomyopathy, neuropathy and foot ulceration. In 2010, 11% of EU adult deaths (634,000) were caused by diabetic complications. These distinct disorders have few effective medicines ...
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 10

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Predictive Genomic Biomarkers Methods for Combination Bevacizumab (Avastin) Therapy in Metastatic Colorectal Cancer (ANGIOPREDICT)

Start date: Feb 1, 2012, End date: Jan 31, 2016,

In recent years the treatment paradigm for metastatic colorectal cancer (mCRC) has evolved in complexity to include newly developed targeted therapeutics. In 2004 bevacizumab (bvz) [Avastin] became the first anti-angiogenic drug to be licensed in malignant disease, based on the results of a randomised trial in advanced metastatic colorectal cancer. Nevertheless, over the past six year period emerg ...
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 12

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"Self-care Support for People with Long Term Conditions, Diabetes and Heart Disease: A Whole System Approach" (EU-WISE)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

"The overall aim of this project is to offer a deeper understanding of the different mechanisms involved in the management of chronic conditions with a specific focus on how initiatives are translated and embedded into the illness management practices in peoples’ everyday life. It is in work, domestic and community settings where these practices are shaped by the emotional, symbolic, ethical, eco ...
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 10

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Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression (DEXLIFE)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

"Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry. Inve ...
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 12

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Innovative Midlife Intervention for Dementia deterrence (In-MINDD)

Start date: Nov 1, 2012, End date: Oct 31, 2015,

The European costs of dementia were estimated €177 billion and there is a growing gap between burden and budget. The debilitation associated with dementia makes it the most feared of conditions related to ageing .Modelling studies have estimated that if obesity rates dropped by 5%, dementia prevalence rates would be lower by 6% and a decline in physical inactivity rate by 5% would reduce dementia ...
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 5

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REsearch into implementation STrategies to support patients of different ORigins and language background in a variety of European primary care settings (RESTORE)

Start date: Apr 1, 2011, End date: Mar 31, 2015,

This project is concerned with optimising the delivery of primary healthcare to European citizens who are migrants who experience language and cultural barriers in host countries. We focus on the implementation of evidence-based health information (e.g. guidelines to enhance communication in cross-cultural consultations) and interventions (e.g. training initiatives on interculturalism and the use ...
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 8

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Apoptosis Modelling for Treatment Decisions in Colorectal Cancer (APO-DECIDE)

Start date: Nov 1, 2012, End date: Oct 31, 2014,

"With the arrival of new colorectal cancer (CRC) therapeutics targeting specific cell signalling pathways, such as anti-EGFR therapy, personalised cancer treatment is at the door step of clinical practise. This progress in drug development contrasts strikingly with current clinical practice, where decision making depends largely on clinical factors such as tumour staging and age of patient, with t ...
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 7

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Glycomics by High-throughput Integrated Technologies (GlycoHIT)

Start date: Jan 1, 2011, End date: Jun 30, 2014,

Protein glycosylation is a post-translational phenomenon that is involved in most physiological and disease processes including cancer. Most of the known cancer-associated glycobiomarkers were discovered individually using liquid chromatography and mass spectroscopy. Though valuable, there is room for improvement in these approaches for the discovery phase. There is also a critical need for innova ...
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 16

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Robotics UBIquitous COgnitive Network (RUBICON)

Start date: Apr 1, 2011, End date: Mar 31, 2014,

Description Self-learning robotic ecology RUBICON will create a self-learning robotic ecology, consisting of a network of sensors, effectors and mobile robot devices. Enabling robots to seamlessly operate as part of these ecologies is an important challenge for robotics R&D, in order to support ap ...
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 10

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CULTivating Understanding and Research through Adaptivity (CULTURA)

Start date: Feb 1, 2011, End date: Jan 31, 2014,

Description CULTURA's innovative adaptive services and interactive environment will offer genuine user empowerment and unprecedented levels of engagement with digital cultural heritage collections and communitiesA key challenge facing curators and providers of digital cultural heritage is to instigate, increase and enhance engagement with ...
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 7

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Linked Heritage - Coordination of Standards and Technologies for the enrichment of Europeana (Linked Heritage)

Start date: Apr 1, 2011, End date: Sep 30, 2013,

Linked Heritage has 3 main objectives: I) to contribute large quantities of new content to Europeana, from both the public and private sectors; II) to demonstrate enhancement of quality of content, in terms of metadata richness, re-use potential and uniqueness; III) to demonstrate enable improved search, retrieval and use of Europeana content.Linked Heritage will facilitate and deliver large-sca ...
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 38

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Utilisation of the mesenchymal stem cell receptome for rational development of uniform, serum-free culture conditions and tools for cell characterization (PurStem)

Start date: Nov 1, 2008, End date: Apr 30, 2012,

Stem cells offer a promising avenue to therapy for a wide range of complaints. However, for this potential to be realized, a consistent and plentiful supply of well-characterised stem cells is essential. There has been relatively little progress in the development of new culture technologies for the large-scale manufacture of mesenchymal stem cells (MSCs). There is a strong possibility that this ...
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