Search for European Projects

27 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)

Start date: Mar 1, 2015, End date: Feb 28, 2020,

Multi-drug resistant Gram-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (M ...
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 23

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Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Start date: Jan 1, 2013, End date: Dec 31, 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

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Physiology of the Intestine: Proteases from the Epithelium (PIPE)

Start date: Apr 1, 2013, End date: Mar 31, 2018,

"In several gastrointestinal diseases such as irritable bowel syndrome or inflammatory bowel diseases, proteolytic homeostasis is disrupted. This disruption has an important impact of the pathophysiology of those diseases. We hypothesized that intestinal epithelial cells are major regulators of this homeostasis by secreting proteases and protease inhibitors, thereby interfering with gut biologica ...
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 1

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Biomarkers of renal graft injuries in kidney allograft recipients (BIOMARGIN)

Start date: Mar 1, 2013, End date: Feb 28, 2018,

In renal allograft recipients, 10-year graft survival has not improved over the past decades. Histological examination of graft biopsies has long been the gold standard to confirm graft injuries, but biopsies are invasive and histological grading is not very robust. There is thus a need for robust, non-invasive methods to predict and diagnose acute and chronic graft lesions, to improve patient tre ...
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 13

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Healthy Aging Through Internet Counselling in the Elderly (HATICE)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

"Diabetes mellitus, hypertension, obesity, hypercholesterolemia, smoking and physical inactivity are common in elderly persons and are all associated with an increased risk of myocardial infarction, stroke and dementia. Efficacious treatments of these cardiovascular diseases are available, but in elderly patients with multiple cardiovascular diseases and risk factors however, treatment is currentl ...
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 7

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European Medical Information Framework (EMIF)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aim ...
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 64

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Reach α-synuclein-dependent neurodegeneration: clinical development of therapeutic AFFITOPE vaccines for Parkinson’s disease and multisystem atrophy (SYMPATH)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

The goal of SYMPATH is to advance clinical development of therapeutic vaccines targeting α-synuclein (aSyn)-driven neurodegenerative diseases (ND). It addresses Parkinson’s disease (PD) and multiple system atrophy (MSA), two synucleopathies, for which no causal therapy exists. Ultimately, both lead to patient disability and death, which along with patient number (PD) and age of onset (MSA, PD) def ...
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 8

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Clinical and system –omics for the identification of the MOlecular DEterminants of established Chronic Kidney Disease (iMODE-CKD)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical researc ...
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 10

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Initial Training Network for Neurogical disorders orchestrated by cytoKines (NEUROKINE)

Start date: Jan 1, 2013, End date: May 31, 2017,

Neuroinflammatory disease, in particular multiple sclerosis affects more than 700.000 people within Europe alone. European countries are at the forefront of neuroimmunological research and students in medicine and biology are greatly attracted by the field. Neuroimmunology research further impacts our understanding of the ethiopathology of other CNS-disorders including Alzheimer’s Dementia and Mor ...
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 13

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"Role of Themis1, a new T cell signaling protein, in normal and pathological immune responses" (THEMIS)

Start date: Mar 1, 2013, End date: Feb 28, 2017,

"A critical step of an immunological response is the activation of T lymphocytes through intracellular signaling pathways downstream of T cell receptors (TCR). THEMIS1 is a new actor of T cell signaling that belongs to a newly identified family of proteins. THEMIS proteins each contain a previously uncharacterized globular domain (called 'CABIT') whose structure and function are currently unknown. ...
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 1

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BBMRI - Large Prospective Cohorts (BBMRI-LPC)

Start date: Feb 1, 2013, End date: Jan 31, 2017,

In recent years, biomedical research has crossed international borders in large, collaborative studies showing the value of multidisciplinarity and scale advantage. This has yielded valuable insights and some led to new and better medicines and treatments for diseases. However, disease-focused studies provide less insight in the real disease onset, the relative disease burden in the population, an ...
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 36

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Best EScalation Treatment in Multiple Sclerosis (MS) (BEST MS)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

"Multiple Sclerosis (MS) is a devastating disease of the central nervous system affecting 2.5 million worldwide. MS is a field of constant therapeutic innovation, a fact which brings hope to young adults since MS is one of the most frequent causes of severe handicap. A major unmet need is to rationalize treatment decisions. To date, there is no way of predicting which patients will best respond to ...
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 5

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Cell-based regenerative medicine: new challenges for EU legislation and governance (EUCelLEX)

Start date: Oct 1, 2013, End date: Sep 30, 2016,

This proposal aims at collecting and analysing facts and figures in order to assess the current legislation on the therapeutic use of somatic cells, and to bridge it with the research infrastructure capacity building. Although EU has adopted 3 Directives on Tissues and cells between 2004 and 2006 to harmonise the procurement, storage and use of cells for therapeutic use in Europe, countries have i ...
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 9

 FINISHED 

European collaborative project on Targeted therapy in renal cell cancer: genetic and tumor-related biomarkers for response and toxicity (EuroTARGET)

Start date: Mar 1, 2011, End date: Aug 31, 2016,

Each year more than 63,000 new cases of kidney cancer are diagnosed in the European Union. Approx. 50% of all patients have metastasized renal cell cancer (mRCC) at presentation or develop metastases during follow-up. 5-year relative survival of mRCC has been extremely poor: between 5 and 10%. In the past few years, so-called targeted therapies that suppress angiogenesis have changed the clinical ...
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 15

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THE ROLE OF ELASTASE/ELASTASE INHIBITOR IN DIALOG BETWEEN INTESTINAL EPITHELIAL CELLS AND MACROPHAGES IN INFLAMMATORY BOWEL DISEASES CONTEXT (EPIMACase)

Start date: Aug 6, 2014, End date: Aug 5, 2016,

Inflammatory Bowel Diseases (IBD) are chronic disorders for which aetiology is unknown and only palliative care is available for patients. In Europe, 2.2 million people suffered of ulcerative colitis or Crohn's disease in Europe, the socio-economic impact of IBD is very heavy. Thus, the development of new and more effective treatments for IBD depends upon a better understanding of the regulation o ...
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 1

 FINISHED 

Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes (DIABAT)

Start date: Oct 1, 2011, End date: Sep 30, 2015,

"The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last years re-discovery of functional BAT in adult humans by several of the members of the ...
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 22

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Introducing diagnostic applications of ‘3Gb-testing’ in human genetics (3GB-TEST)

Start date: Sep 1, 2013, End date: Aug 31, 2015,

The landscape of genetic testing is rapidly changing. Soon, whole genome sequence analysis (3Gb-testing) will be an effective and financially viable alternative to targeted gene analysis. New technologies that allow efficient sequencing of a whole human genome in a diagnostic setting will have an enormous impact on diagnostic centres replacing many existing molecular and cytogenetic tests.Patients ...
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 11

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European Sequencing and Genotyping Infrastructure (ESGI)

Start date: Feb 1, 2011, End date: Jul 31, 2015,

The objective of this project is the integration of world class high-throughput sequencing and genotyping facilities that will provide sequencing and genotyping technologies and data analysis methodologies to the scientific community.The European Sequencing and Genotyping Infrastructure (ESGI) will enable external users to generate data rapidly and to acquire knowledge efficiently. By providing ac ...
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 11

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The role of intestinal microflora in non-alcoholic fatty liver disease (NAFLD) (FLORINASH)

Start date: Jan 1, 2010, End date: Dec 31, 2014,

As worldwide metabolic disease pandemics rise relentlessly with their concomitant clinical complications such as non alcoholic fatty liver disease, FLORINASH proposes an innovative research concept to address the role of intestinal microfloral activity in the pathogenesis of NAFLD. Firstly, to discover novel metabolic markers for the differential diagnosis and prediction of patient risk. Secondly, ...
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 6

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Identifying Strategies to Manipulate the Immune System to Increase the Control of Tumors and Metastases (ISMISICOTAM)

Start date: Oct 1, 2010, End date: Sep 30, 2014,

"The number of cancer patients is increasing and effective treatments are still limited. The identification of tumor associated antigens (TAA) has allowed for the stimulation of the immune system to recognize and destroy solid tumors. The most common strategy is to increase tumor specific cytotoxic CD8 T cell responses by vaccination of the patient with dendritic cells (DCs) pulsed with TAA peptid ...
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 1

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Antigen processing and T cell recognition of intravacuolar parasites (APATRIVAP)

Start date: Jun 28, 2010, End date: Jun 27, 2014,

"Antigen recognition by CD8 T cells enables us to combat infectious pathogens, such as viruses and parasites. This feature represents the groundwork for vaccine efficacy. Immune surveillance is achieved by screening short peptides presented by major histocompatibility complex (MHC) class I molecules on the surface of infected cells. Recognition of foreign peptide-MHC I complexes triggers cytokine ...
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 1

 FINISHED 

In vivo characterisation of Follicular Helper T cells (TFHcells)

Start date: Jun 1, 2010, End date: May 31, 2014,

An effective immune response relies on the helper T cell (TH) regulated development of high-affinity B cell memory. Follicular Helper T (TFH) cells are the critical regulators of the B cell response. Until recently, TFH cells were considered fully differentiated cells prone to apoptosis. However, we showed that protein vaccination selects locally effector TFH cells that become memory TFH cells and ...
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 1

 FINISHED 

IMPROVEMENT OF TOOLS AND PORTABILITY OF MASS SPECTROMETRY-BASED CLINICAL PROTEOMICS AS APPLIED TO CHRONIC KIDNEY DISEASE (PROTOCLIN)

Start date: May 15, 2010, End date: May 14, 2014,

The number of patients with chronic kidney disease (CKD) is increasing steadily due to extended life expectancy, long lasting diabetes and obesity. Early unambiguous detection of patients at risk is both a clinical and scientific challenge. Capillary electrophoresis coupled to mass spectrometry (CE-MS), developed by Mosaiques Diagnostics (MD, SME, Germany), has been shown to be an excellent tool f ...
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 4

 FINISHED 

Characterisation of PI3K isoform roles in pancreatic cancerogenesis (PaCa/PI3K)

Start date: Apr 1, 2011, End date: Mar 31, 2014,

PI 3-kinases (PI3Ks) are key signal transduction enzymes which are generally considered to be excellent new targets for therapeutic interference. Mammals have multiple PI3K isoforms.During my UK post-doctoral training funded by EIF, I have created and characterized new mouse models targeting one isoform of PI3K, p110beta, which physiological role was unknown. Isoform-specificity of p110beta in cel ...
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 1

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Sharing capacity across Europe in high-throughput sequencing technology to explore genetic variation in health and disease (GEUVADIS)

Start date: Oct 1, 2010, End date: Dec 31, 2013,

"High-throughput next-generation DNA sequencing technologies allow investigators to sequence entire human genomes at an affordable price and within a short time frame. The correct interpretation, storage, and dissemination of the large amount of produced genomics data generate major challenges. Tackling these challenges requires extensive exchange of data, information and knowledge between medical ...
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 17

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Development of biotherapies for growth plate disorders (GeneCellTher)

Start date: Nov 1, 2009, End date: Oct 31, 2013,

Skeletal dysplasias are a diverse and heterogeneous group of hereditary disorders characterized by malformations of bone and cartilage. These conditions affect development patterns in bones of growing children, and the clinical severity ranges from mild short stature to highly disfiguring, and even to lethal forms. Their treatment is very challenging, typically with no or limited success. This pro ...
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 1

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"Ethical, Legal, Social and Practical Barriers to Sharing between Biobanks in Europe" (ELSPBSBBE)

Start date: Sep 1, 2011, End date: Aug 31, 2013,

"Biological samples, such as tissues, DNA, and cells are an increasingly important resource for advancing research on human diseases. In the last two decades, important efforts have been made to organize such samples and data into biobanks in order to make these samples and data available for sharing between researchers. That being said, there remains many barriers and challenges to sharing betwe ...
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 2