Search for European Projects

14 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Communication between immune cells via release of RNA-carrying vesicles: Lessons from viruses (INTERCOM)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

"Communication between immune cells is crucial for regulating the magnitude and quality of immune responses. A newly uncovered means of intercellular communication involves transfer of small cell-derived vesicles. I recently discovered that vesicles released by immune cells are enriched for small noncoding RNAs, which may act as regulatory RNAs that can influence gene expression in vesicle-targete ...
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 1

 FINISHED 

Mechanism-Based Integrated Systems for the Prediction of Drug-Induced Liver Injury (MIP-DILI)

Start date: Feb 1, 2012, End date: Jan 31, 2017,

The current test systems employed by Industry are poorly predictive for Drug induced liver injury (DILI). The ‘MIP-DILI’ project will address this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test sys ...
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 29

 FINISHED 

Developmental neurotoxicity assessment of mixtures in children (DENAMIC)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. ...
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 18

 FINISHED 

Mechanisms of the Development of ALLergy (MEDALL)

Start date: Dec 1, 2010, End date: May 31, 2015,

Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL (Mechanisms of the Development of Allergy) aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational app ...
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 24

 FINISHED 

"The development, validation and implementation of human systemic Toxic Equivalencies (TEQs) as biomarkers for dioxin-like compounds" (SYSTEQ)

Start date: Feb 1, 2009, End date: Nov 30, 2013,

"Chlorinated dioxins and biphenyls (PCBs) commonly occur in the human food chain and can still be detected at levels that might cause long term health effects. Exposure to dioxin-like compounds involves a complex mixture with a common mechanism of action involving endocrine, developmental, carcinogenic, immuno and neurological effects. Risk assessment is done with an additive model for mixture tox ...
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 6

 FINISHED 

Profiling the toxicity of new drugs: a non animal-based approach integrating toxicodynamics and biokinetics (Predict-IV)

Start date: May 1, 2008, End date: Oct 31, 2013,

The overall aim of Predict-IV is to develop strategies to improve the assessment of drug safety in the early stage of development and late discovery phase, by an intelligent combination of non animal-based test systems, cell biology, mechanistic toxicology and in-silico modelling, in a rapid and cost effective manner. A better prediction of the safety of an investigational compound in early develo ...
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 20

 FINISHED 

Climate change, Environmental contaminants and Reproductive health (CLEAR)

Start date: May 1, 2009, End date: Oct 31, 2013,

The research project investigates the possible impact of global climate change on reproductive health in one Arctic and two European populations. The key questions to be addressed are, firstly, how may climate change influence human exposure to widespread environmental contaminants and, secondly, how may contaminants impact occurrence of reproductive disorders as sensitive indicators of health? To ...
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 8

 FINISHED 

"Health Effects of Indoor Pollutants: Integrating microbial, toxicological and epidemiological approaches" (HITEA)

Start date: Apr 1, 2008, End date: Mar 31, 2013,

"Healthy housing and good indoor air quality are important goals of public health. However, biological indoor pollution due to dampness, moisture and mold is an emerging environmental health issue, as recognized in EU indoor air policy documents. Prevalence of dampness is remarkable, and may still increase due to demands of energy savings and extreme weather periods and floods associated with clim ...
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 10

 FINISHED 

Genomics biomarkers of environmental health (EnviroGenomarkers)

Start date: Mar 1, 2009, End date: Feb 28, 2013,

This project concerns the first large-scale application of the full range of –omics technologies in a population study aiming at a) the discovery and validation of novel biomarkers predictive of increased risks of a number of chronic diseases, b) the exploration of the association of such biomarkers with environmental exposures, including high-priority pollutants and emerging exposures, and c) the ...
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 12

 FINISHED 

European Study of Cohorts for Air Pollution Effects (ESCAPE)

Start date: Jun 1, 2008, End date: Nov 30, 2012,

"European policy making is hampered by considerable uncertainty about the magnitude and nature of the impacts of long term exposure to air pollution on human health. ESCAPE is a collaboration of more than 30 European cohort studies including some 900,000 subjects. It is aimed at quantifying health impacts of air pollution and at reducing uncertainty. ESCAPE will also test new hypotheses on specifi ...
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 26

 FINISHED 

Life Cycle Assessment of Environment-Compatible Flame Retardants ( Prototypical case study) (ENFIRO)

Start date: Sep 1, 2009, End date: Nov 30, 2012,

Brominated flame retardants (BFRs) will be phased out because of their environmental hazards. Less toxic alternatives appear to be available already but comprehensive information on their possible toxicological effects are lacking. ENFIRO offers a prototypical case study on substitution options for BFRs resulting in a comprehensive dataset on viability of production and application, environmental ...
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 14

 FINISHED 

Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease (LipidomicNet)

Start date: May 1, 2008, End date: Oct 31, 2012,

Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quan ...
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 27

 FINISHED 

Mechanisms of early protective exposures on allergy development (EFRAIM)

Start date: Feb 1, 2008, End date: Jan 31, 2012,

Allergy has developed into a major health concern in Europe. Allergic diseases can currently be managed effectively but not cured. The onset of allergies stars early in life and there is increasing evidence that exogenous factors affecting the incidence of these illnesses exert their effect early in life, in part even prenatally. The highly interdisciplinary EFRAIM project will prospectively inves ...
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 15

 FINISHED 

ENVIRONMENTAL HEALTH RISKS IN EUROPEAN BIRTH COHORTS (ENRIECO)

Start date: Mar 1, 2009, End date: Feb 28, 2011,

"The overall aim of ENRIECO is to advance our knowledge on specific environment and health causal relationships in pregnancy and birth cohorts by providing support to exploitation of the wealth of data generated by past or ongoing studies funded by the EC and national programmes. Specific objectives are to make inventories of birth cohorts, assure quality and interoperability of exposure, health ...
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 9