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Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID)

Start date: Jan 1, 2011, End date: Jun 30, 2015,

...esource intensive stages of preclinical and clinical development.The project will encompass the parallel progression of the three compound families through: A) Lead Optimization Chemistry efforts and MoA studies (Genetic and Proteomic) for whole cell inhibitors, B) In vitro and in vivo evaluation of a new orally bioavailable Beta-lactam alone or in combination with a Beta-lactamase inhibitor to ev ...
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