2 European Projects Found
Searched on 125080 European Projects
FINISHED
Specificity Drift in The Kinome During Cancer Development and Evolution (KINOMEDRIFT)
Start date: Nov 1, 2012, End date: Oct 31, 2016,
"Cellular signaling networks have evolved to enable swift and accurate responses, even in the face of genetic or environmental perturbation. While we can readily assess dynamics in phosphorylation sites, our ability to model and predict the associated networks of kinases are hampered by the fact that we lack information on catalytic specificity for around 60% of the 538 human protein kinases (kino ...
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2
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Predicting individual response and resistance to VEGFR/mTOR pathway therapeutic intervention using biomarkers discovered through tumour functional genomics (PREDICT)
Start date: Jan 1, 2011, End date: Dec 31, 2014,
"The strategic development of accurate biomarkers to predict response to therapy in cancer medicine will enhance clinical outcome and reduce the health economic impact of drug resistant disease. The PREDICT consortium will identify and validate predictive biomarkers for two drugs which have direct anti-tumour cell and anti-angiogenic activity and for which no established predictive biomarkers of t ...
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