Search for European Projects

32 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

Far from receding, the threats posed by infections with epidemic potential grow ever greater. Although Europe has amongst the best healthcare systems in the world, and also the world’s supreme researchers in this field, we lack co-ordination and linkage between networks that is required to respond fast to new threats. This consortium of consortia will streamline our response, using primary and sec ...
Read Project

 27

 FINISHED 

Targeting novel lipid pathways for treatment of cardiovascular disease (Athero-Flux)

Start date: Sep 1, 2013, End date: Aug 31, 2018,

Lipid lowering has significantly reduced cardiovascular disease (CVD) mortality in EU. However, the aim to abolish CVD in EU is far from achieved and attempts to improve on the benefits of statins with new agents have not yet delivered new therapeutics. The Consortium Athero-Flux builds on FP7-generated large-scale lipidomics data showing that specific sphingolipids and in particular distinct cer ...
Read Project

 12

 FINISHED 

Mechanism of homology search during homologous recombination (Multiple Search)

Start date: Feb 1, 2015, End date: Jan 31, 2018,

"Homologous recombination is a mechanism by which DNA double-strand breaks are faithfully repaired using the sequence information present on an intact duplex DNA. The efficiency of this mechanism is crucial for cell survival, and its accuracy is of prime importance for genomic stability. Although being the signature reaction of homologous recombination, the search for homology performed by the bro ...
Read Project

 1

 FINISHED 

Pathogen COinfection: HIV, Tuberculosis, Malaria and Hepatitis C virus (PathCO)

Start date: Nov 1, 2012, End date: Oct 31, 2017,

Acquired immune deficiency (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. In addition to these pathogens, 170 million people are infected with hepatitis C virus (HCV), which leads to chronic liver disease. Because of shared routes of transmission, HCV co-infection is recognized as a major cause of morbidity and mortality among HIV-1 infected per ...
Read Project

 11

 FINISHED 

Quantitative T cell Immunology (QuanTI)

Start date: May 1, 2013, End date: Apr 30, 2017,

The primary objective of this ITN is to train a new generation of European quantitative immunologists, who will be able to address challenges arising in Systems Immunology. This will be achieved with the proposed Network, Quantitative T cell Immunology (QuanTI), that will train 11 ESRs and 4 ERs, bringing together renowned experimental and theoretical scientists from private and academic instituti ...
Read Project

 12

 FINISHED 

Esrrb Function in Mitotic Bookmarking (EFIMB)

Start date: Mar 1, 2015, End date: Feb 28, 2017,

"The preservation of cell identity depends on the maintenance of gene expression programs through mitosis. Generally, this is mediated by epigenetic systems of repression involving Polycomb proteins and H3K9 and DNA methyltransferases. Pluripotent Embryonic Stem (ES) cells constitute an exception as abrogation of these systems does not lead to detrimental consequences, with defects appearing only ...
Read Project

 1

 FINISHED 

Anti-Parasitic Drug Discovery in Epigenetics (A-PARADDISE)

Start date: Feb 1, 2014, End date: Jan 31, 2017,

This proposal builds on the proven methodology developed in the SEtTReND FP7 project to develop inhibitors of schistosome HME as lead compounds for new drugs. We will employ a target-based strategy for the development of novel drug leads against schistosomiasis, leishmaniasis, Chagas disease and malaria by targeting histone modifying enzymes (HME), in particular those involved in acetylation/deace ...
Read Project

 16

 FINISHED 

Infection biology training network: shaping the future of infectious diseases treatments (INBIONET)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

"The increasing number of bacteria resistant to all antibiotics and antimicrobials and the virtual lack of antiviral drugs make necessary to develop therapeutics based on new targets/approaches. European-wide-acting sectors must permanently improve their capabilities and capacities to cope with these challenges. Thus, the demand for experts trained to understand infectious diseases in their whole ...
Read Project

 11

 FINISHED 

Paving the way towards HIV eradication/control (HIT HIDDEN HIV)

Start date: Dec 1, 2012, End date: Oct 31, 2016,

Major advances in HIV/AIDS treatment regimens have fundamentally altered the natural history of the disease and sharply reduced HIV-related morbidity and mortality in countries where such treatments are accessible. The most notable advance is the use of combination antiretroviral therapy or ART. However, ART is unable to achieve virus eradication or “sterilizing cure”. Indeed, in most cases, viral ...
Read Project

 5

 FINISHED 

Engineering multicellular biocircuits: programming cell-cell communication using plasmids as wires (PLASWIRES)

Start date: Oct 1, 2013, End date: Sep 30, 2016,

Conjugation is a natural communication mechanism used by plasmids (autonomous self- replicating DNA molecules) to travel from bacteria to bacteria as a survival strategy. The genes and proteins that control conjugation are well known by biologists. This conjugation hardware is highly specific and robust and has been refined over millions of years of natural selection. It allows the independent tra ...
Read Project

 4

 FINISHED 

The Human Brain Project (HBP)

Start date: Oct 1, 2013, End date: Sep 30, 2016,

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the ...
Read Project

 116

 FINISHED 

Natural Killer Cell-Based Anti-Cancer Immunotherapies: Research training in molecular medicine and biotechnology business (NATURIMMUN)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

"In the research part we will deal with the basic principles of the innate immune defense used to control tumors and viral infections with a focus on NK and NK/T cells, including analysis of NK receptor genomics/epigenetics, gene polymorphisms/disease linkage, differentiation of hitherto unrecognized NK cell subpopulations and novel ligands for NK receptors exposed by tumor and/or virally infected ...
Read Project

 12

 FINISHED 

Love wave fully integrated Lab-on-Chip platform for food pathogen detection (LOVE-FOOD)

Start date: Sep 1, 2012, End date: Feb 29, 2016,

The project is aimed at developing a fully integrated lab-on-chip microsystem platform, performing multimodal analysis of several analytes combining nucleic acid and whole bacteria detection. The system will allow directly and without prior culture the identification in one single run of a multiplicity of pathogens and their specific sequences responsible will be targeted and identified. The heart ...
Read Project

 8

 FINISHED 

Understanding the infection by the bacterium Listeria monocytogenes as a way to address key issues in biology (MODELIST)

Start date: Jun 1, 2009, End date: May 31, 2015,

Host-pathogen interactions have recently received much attention. Yet, a more comprehensive understanding of these interplays should provide fundamental advances in biology and help generating new therapeutics. The intracellular bacterium Listeria monocytogenes has emerged as an exceptional model organism to address key questions in biology such as actin-based motility, phagocytosis and post-trans ...
Read Project

 1

 FINISHED 

Role of Quorum Sensing mechanisms in the Immune System s regulation (QSIS)

Start date: Jun 1, 2010, End date: May 31, 2015,

The homeostatic control of lymphocyte numbers provides the immune system with a basic mechanism that shapes the repertoire of the immune-competent cells and therefore, the capacity to respond to exogenous antigens as well as to maintain self-tolerance. Homeostatic mechanisms will also enable the re-establishment of the immune system following disruption (irradiation or chemotherapy). During the pr ...
Read Project

 1

 FINISHED 

Monoallelic Gene Expression in Malaria Parasites: A Key Mechanisms in the Pathogen's Survival Strategy (PLASMOESCAPE)

Start date: Jun 1, 2010, End date: May 31, 2015,

An important number of human and animal pathogens use antigenic variation of surface proteins as a mechanism to avoid destruction by the host s immune system. Most escape mechanisms rely on the successive expression of members of gene families in a mutually exclusive manner, a biological process which remains elusive at the molecular level. The protozoan pathogen Plasmodium falciparum, which infec ...
Read Project

 1

 FINISHED 

In vitro and in vivo examination of the spatial and temporal distribution of synaptic inputs and synaptic integration in layer 2/3 visual cortical neurons (VisualDendrite)

Start date: May 22, 2013, End date: May 21, 2015,

A particularity of neurons in sensory cortex is to be tuned to specific stimulation features ; for example, in the primary visual cortex, some neurons are selective for the orientation of the stimulus. The large dendritic trees of pyramidal cortical neurons extend over hundreds of microns, allowing neurons to receive thousands of synaptic inputs. Neurons integrate and compute these inputs to produ ...
Read Project

 1

 FINISHED 

RNA virus population diversity, virulence, attenuation and vaccine development (RNAVIRUSPOPDIVNVAX)

Start date: Oct 1, 2009, End date: Mar 31, 2015,

RNA viruses have the highest mutation frequencies in nature, which are in large part attributed to the low fidelity of their viral RNA-dependent RNA polymerases (RdRp). Explosive replication kinetics coupled with high mutation rates quickly generate highly diverse populations that have been observed for all RNA viruses. Recently, we have developed a model system to study the roles that RNA virus m ...
Read Project

 1

 FINISHED 

Molecular and ecological characterisation of bacterial community-mediated protection against infection in the zebrafish (ZEBRAPROTECT)

Start date: Mar 1, 2013, End date: Feb 28, 2015,

"Animal-associated commensal microbiota play a crucial role in protecting their hosts against invading pathogens through a process called colonisation resistance. A number of hypotheses have been proposed to explain this protective effect. These include direct competition between commensal and pathogens (barrier effect), alteration of the host immune defence (immuno-stimulation), or protection by ...
Read Project

 1

 FINISHED 

Bacteria with Multiple Chromosomes: Interplay between genome architecture and cell physilogy (BMC)

Start date: Mar 1, 2013, End date: Feb 28, 2015,

"Bacteria with Multiple-Chromosomes (BMC) are relatively frequent. This project was designed to understand the advantages of such a genomic organization. Based on observations from comparative genomics these could be: shorter generation time by providing additionalorigins of replication, a differential chromosome copy number regulation that changes relatives gene doses of the unlinked gene sets an ...
Read Project

 1

 FINISHED 

Role of the PfAlbas, a novel DNA and RNA binding protein family, in Plasmodium falciparum chromatin biology and RNA regulation (PfAlba)

Start date: Feb 1, 2013, End date: Jan 31, 2015,

Antigenic variation is a common strategy utilized by intracellular pathogens to evade immune detection. Plasmodium falciparum, the causal agent of the most lethal form of malaria, modulates antigenic variation of the ~60 member 'var' virulence gene family by exhibiting mutually exclusive, monoallelic expression. This is achieved by spatially and epigenetically regulating var transcription such tha ...
Read Project

 1

 FINISHED 

RNAi-mediated viral immunity in insects (AntiviralRNAi)

Start date: Oct 1, 2009, End date: Dec 31, 2014,

RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA (dsRNA). One of the functions of this pathway is the defense against parasitic nucleic acids: transposons and viruses. Previous results demonstrated that viral infections in Drosophila melanogaster are fought by an antiviral RNAi response and that components of the endocytic pa ...
Read Project

 1

 FINISHED 

Specific functions of individual Cdc42 and polarity protein variants in cellular processes and glioblastoma progression (Cdc42 and Glioma)

Start date: Oct 1, 2012, End date: Sep 30, 2014,

The Rho-GTPase Cdc42 is a key regulator of the actin and microtubule network, thereby regulating cellular processes like cell polarization and motility or membrane traffic. Two isoforms of Cdc42 exist; one ubiquitously expressed, the other being brain-specific. Most studies have focused on the former and specific functions of the brain-restricted variant remain obscure. Recent observations from Et ...
Read Project

 1

 FINISHED 

The Integron Cassette Dynamics and the Integrase Gene Expression (ICADIGE)

Start date: Oct 1, 2012, End date: Sep 30, 2014,

"Bacterial antimicrobial resistance has become one of the major concerns in modern medicine. It is currently responsible in Europe for 15 times as many deaths as AIDS every year. Not surprisingly this phenomenon is one of the Top Six Health Topics for the eCDC.Bacteria have shown a remarkable evolvability towards resistance. One of the most worrisome mechanisms observed, is the integron, a highly ...
Read Project

 1

 FINISHED 

Structural studies of HK97 bacteriophage assembly and maturation (HK97 maturation)

Start date: Sep 1, 2011, End date: Aug 31, 2014,

Virus maturation is virtually universal and allows the transition from an initially assembled non-infectious and fragile particle to a robust infectious virion. Siphophage HK97 is an accessible model system, to study assembly and maturation, for which intermediates can be isolated and myriad structural, biophysical and biochemical data are available. The capsid protein fold similarity between HK97 ...
Read Project

 2

 FINISHED 

HIV and dendritic cells: the immunologycal and virological roles of SamHD1 (HIV innate immunity)

Start date: May 14, 2012, End date: May 13, 2014,

"Dendritic cells (DC) are the front-line of virus detection and trigger the response of the innate and adaptive immune system. DCs ""patrol"" in the body and seek pathogens such as viruses. When they catch viruses, they initiate immune responses primarily in lymph nodes and lymphoid tissue. DCs acquire a mature phenotype while they migrate towards the lymphoid tissues in order to process and prese ...
Read Project

 1

 FINISHED 

Longitudinal analysis of human CD4+FOXP3+ regulatory T cell subpopulations in acute graft-versus-host disease (Treg-in-GVHD)

Start date: Apr 1, 2012, End date: Mar 31, 2014,

Allogeneic hematopoietic stem cell transplantation (HSCT) is an increasingly used intensive therapy to treat patients with hematological malignancies and other life-threatening hematological and genetic diseases. Acute graft-versus-host disease (aGVHD) is the main complication of HSCT and an important cause of mortality. Cellular therapy with CD4+FOXP3+ regulatory T cells (Treg), a population with ...
Read Project

 1

 FINISHED 

Homeostasis and rupture of the gut epithelium in the presence of commensals and pathogens (HOMEOEPITH)

Start date: Feb 1, 2009, End date: Mar 31, 2014,

"The molecular cross talks occuring at the interface between the intestinal epithelium and bacterial flora will be studied at two levels : (i) how commensals and pathogens affect innate immune signalling, thereby leading to tolerance of the resident microbiota, and inflammatory rejection of the pathogens. The theme of commensals and pathogens regulating this innate response, particularly how they ...
Read Project

 1

 FINISHED 

"Formation, maintenance and differentiation of the extraembryonic endoderm lineage" (EXEL)

Start date: Mar 1, 2012, End date: Feb 28, 2014,

"The goals of regenerative medicine require a deep understanding of cell lineage and differentiation, developmental potential and fate. Stem cells representing each of the three first cell lineages of the mammalian blastocyst embryo, TS (trophectoderm), XEN (extraembryonic endoderm, exEn) and ES (epiblast) can be isolated, maintained and differentiated and provide tremendous tools for cell-based t ...
Read Project

 1

 FINISHED 

Innate lymphoid cells in intestinal homeostasis and immunity (ILCHI)

Start date: Mar 1, 2012, End date: Feb 28, 2014,

"The nuclear hormone receptor RORγt marks a family of pro-inflammatory lymphoid cells, which includes adaptive IL-17-producing helper T cells (Th17), as well as subsets of innate lymphoid cells (ILCs), such as lymphoid tissue inducer (LTi) cells and IL 22-producing NKp46+ cells. These cells are required for the development of lymphoid tissues, homeostasis with symbiotic microbiota and defense agai ...
Read Project

 1

 FINISHED 

Research capacity for the implementation of genetic control of mosquitoes (INFRAVEC)

Start date: Sep 1, 2009, End date: Feb 28, 2014,

Mosquitoes transmit a variety of infectious diseases that cause a tremendous burden to public health. Due to climate changes and to the increase in international trade and tourism the threats posed by mosquitoes are increasingly affecting large parts of Europe, causing understandable concerns among the populations of many Member States. Control methods, mainly based on insecticide usage, are strug ...
Read Project

 31

 FINISHED 

City multi-Role Optimized Vehicle (CITY MOVE)

Start date: Jan 1, 2010, End date: Mar 31, 2013,

"The delivery of freight in urban areas is based on general purpose commercial vehicles, not dedicated to a mission in a very specific scenario like urban areas. This is particularly true for medium vehicles (7,5-12 tons) that are however widely used in towns. CITY MOVE aims to develop a new concept for urban delivery vehicles, a real breakthrough from the actual vehicle platforms, using the lates ...
Read Project

 15