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5 European Projects Found

Searched on 125080 European Projects

 FINISHED 

STRATEGY TO INHIBIT TGF-Beta IN LIVER DISEASE (IT-LIVER)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

Chronic liver diseases (CLD) and their end-stages, cirrhosis and hepatocellular carcinoma (HCC), are leading causes of morbidity and mortality worldwide with enormous socio-economic costs. Patients with liver cirrhosis are at high risk of deadly hepatic failure and over 80% of HCC develop on a cirrhotic background. HCC ranks as the 5th most common cancer and with >600,000 deaths per annum it const ...
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 12

 FINISHED 

Evolution and Transfer of Antibiotic Resistance (EVOTAR)

Start date: Oct 1, 2011, End date: Sep 30, 2015,

Antibiotics are essential therapeutics in the treatment of bacterial infections. However, the indiscriminate use of antibiotics has led to the emergence of antibiotic resistant bacteria that pose a major threat to human health as options for treating infections by these bacteria have become limited. The evolution, emergence and spread ofantibiotic resistance genes are still only poorly understood ...
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 19

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Predicting antibiotic resistance (PAR)

Start date: Apr 1, 2010, End date: Mar 31, 2013,

"The aim of this proposal is to describe and predict the dynamics of antibiotic resistance development at the level of the drug target, the microbe and the host. That is, we want to generate the knowledge required to be able to connect resistance mechanism --> bacterial physiology and fitness --> bacterial survival within a host --> bacterial spread between hosts. To achieve this goal we will deve ...
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 12

 FINISHED 

Unravelling the molecular basis of common complex human disorders using the dog as a model system (LUPA)

Start date: Jan 1, 2008, End date: Jun 30, 2012,

Despite major efforts, identifying susceptibility genes for common human diseases - cancer, cardiovascular, inflammatory and neurological disorders - is difficult due to the complexity of the underlying causes. The dog population is composed of ~ 400 purebred breeds; each one is a genetic isolate with unique characteristics resulting from persistent selection for desired attributes or from geneti ...
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 23

 FINISHED 

EFFECT OF NATURAL VIRAL RNA SEQUENCE VARIATION ON INFLUENZA VIRUS RNA FUNCTION (RNAFLU)

Start date: Feb 1, 2008, End date: Jan 31, 2010,

"Influenza A virus has an amazing ability to rapidly change its properties. We believe that pathogenic properties of an influenza virus could be determined also by differences in influenza virus RNA sequence that do not affect the protein sequence of the virus genome. In other words, sequences that affect structure and/or function of the viral RNA, could themselves contribute to the pathogenic pro ...
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