6 European Projects Found
Searched on 125080 European Projects
FINISHED
Dynamic signalling networks in Diabetic Nephropathy (DN) – New avenues to a personalized therapy.- (DNCure)
Start date: Jun 1, 2014, End date: May 31, 2019,
Dynamic signalling networks in Diabetic Nephropathy (DN) – New avenues to a personalized therapy.-We have developed an exquisite experimental platform that facilitates the systematic unravelling of the signallingnetworks leading to (1) the initiation, (2) the progression and (3) the potential regeneration of podocytes inDN, paving the way to novel therapeutic strategies:(1) DN initiation: Identifi ...
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1
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The lysine-specific demethylase1 (LSD1) in physiology and pathology (LSD1)
Start date: Apr 1, 2013, End date: Mar 31, 2018,
"The identification of the first histone demethylase lysine-specific demethylase 1 (LSD1) established not only the concept of reversible histone methylation in epigenetic regulation but also translated this fundamentally novel biological observation into understanding the molecular mechanisms regulation stemness, differentiation, proliferation, and pathological growth. To unravel in an unbiased an ...
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1
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Molecular basis of the outer membrane permeability (TRANSLOCATION)
Start date: Jan 1, 2013, End date: Dec 31, 2017,
Overcoming the barriers that the cell envelope and efflux pumps provide to Gram-negative bacteria is a major bottleneck in the discovery and development of new antibiotics. To respond to this Call we are extending our current network on antibiotic translocation and propose an ambitious project ranging from identification of novel resistance mechanisms in clinical bacterial isolates to crystallizat ...
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28
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Pathogen COinfection: HIV, Tuberculosis, Malaria and Hepatitis C virus (PathCO)
Start date: Nov 1, 2012, End date: Oct 31, 2017,
Acquired immune deficiency (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. In addition to these pathogens, 170 million people are infected with hepatitis C virus (HCV), which leads to chronic liver disease. Because of shared routes of transmission, HCV co-infection is recognized as a major cause of morbidity and mortality among HIV-1 infected per ...
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11
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Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle (ODIN)
Start date: Nov 1, 2013, End date: Oct 31, 2017,
Vitamin D deficiency has significant implications for human health and impacts on healthy growth and development and successful aging. Fundamental knowledge gaps are barriers to implementing a safe and effective public health strategy to prevent vitamin D deficiency and optimize status. ODIN will provide the evidence to prevent vitamin D deficiency in Europe and improve nutrition and public health ...
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32
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A Gateway to European Kidney Research Resources - KidneyConnect (KidneyConnect)
Start date: Aug 1, 2013, End date: Jul 31, 2016,
Diabetes, Cardiovascular and Chronic kidney (DCC) -diseases are relentlessly increasing globally, causing enormous human suffering, premature deaths and unsustainable costs. Leading European research has indisputably pointed that the kidney filtration barrier and its epithelial cell, the podocyte, is a common denominator for the DCC-diseases. However, European excellence and expertise have remaine ...
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