Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Start date: Jan 1, 2013, End date: Dec 31, 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

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Multidisciplinary Approaches to Translational Research In Conduct Syndromes (MATRICS)

Start date: Mar 1, 2014, End date: Feb 28, 2019,

Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypoth ...
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 21

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Aggression subtyping for improved insight and treatment innovation in psychiatric disorders (AGGRESSOTYPE)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
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 27

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Personalized diagnosis and treatment of hyperinsulinemic hypoglycaemia caused by beta-cell pathology (BETACURE)

Start date: Apr 1, 2014, End date: Mar 31, 2018,

Background:Hyperinsulinaemic hypoglycaemia (HH) is a potentially lethal disease caused by over functioning beta cells derived from the pancreatic islets of Langerhans. Lethal HH and brain damage is a problem especially in infants with congenital HH. Current therapeutic approaches are associated with severe side effects/morbidity (diabetes, exocrine pancreas insufficiency etc.) considered acceptabl ...
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 17

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Measuring and modeling how misregulation in gene regulatory networks causes intellectual disability (MisRegulatID)

Start date: Mar 1, 2014, End date: Feb 28, 2018,

Intellectual disability (ID) is a neurodevelopmental disorder with a strong genetic component. For many patients the genetic cause is yet unknown as no protein-damaging mutations can be identified. To accurately predict the risk for ID from a person’s complete DNA sequence, it is essential to know how and when genetic perturbation of a gene regulatory element causes abnormal neurodevelopment. The ...
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Translational Adolescent and Childhood Therapeutic Interventions in Compulsive Syndromes (TACTICS)

Start date: Jan 1, 2012, End date: Jun 30, 2017,

Compulsivity is characterized by a repetitive, irresistible urge to perform a behavior, the experience of loss of voluntary control over this intense urge, the diminished ability to delay or inhibit thoughts or behaviors, and the tendency to perform repetitive acts in a habitual or stereotyped manner. Compulsivity is a cross-disorder trait underlying phenotypically distinct psychiatric disorders t ...
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 13

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Towards gene identification and personalized prophylactic medication for lithiopathies in lithium-using patients (Lithiopathies)

Start date: May 1, 2014, End date: Apr 30, 2017,

Lithium is widely prescribed and the mainstay treatment for bipolar disorders. Unfortunately, lithium treatment often leads to adverse side effects (lithiopathies) like hypercalcaemia, nephrogenic diabetes insipidus and chronic kidney disease.Despite the above lithiopathies, cessation of lithium therapy is not an option for most patients, because there is no good alternative and the bipolar disord ...
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 1

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BeTheCuRE (BTCURE)

Start date: Apr 1, 2011, End date: Mar 31, 2017,

BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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 41

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European Autism Interventions - A Multicentre Study for Developing New Medications (EU-AIMS)

Start date: Apr 1, 2012, End date: Mar 31, 2017,

Despite dramatic advances in molecular and imaging technologies, there are currently no effective pharmacological treatments for the core symptoms of autism spectrum disorder (ASD). Major obstructions to this include a lack of aetiologically-driven or pathophysiologically-accurate animal models; an absence of tests that indicate efficacy; and reliance of clinical trials on DSM/ICD10 categories wh ...
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 29

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Transforming Magnetic Resonance Spectroscopy into a Clinical Tool (TRANSACT)

Start date: Mar 1, 2013, End date: Feb 28, 2017,

"In vivo Magnetic Resonance Spectroscopy and Spectroscopic Imaging (MRS(I)) are unique, indispensable techniques for non-invasive metabolic imaging. Important areas where MRS(I) can make a difference are oncology and neurology, where metabolic changes due to, e.g., tumour formation, can be detected earlier and more sensitively than with morphological imaging modalities alone. Despite its huge prov ...
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 10

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A European multicentre double-blind placebo-controlled phase III trial of nilvadIpine in mild to moderate Alzheimer’s disease (NILVAD)

Start date: Jan 1, 2012, End date: Dec 31, 2016,

Alzheimer’s disease (AD) is an ever-increasing public health concern among the aging population and is the most common form of dementia affecting more than 15 million individuals worldwide and around 5 million Europeans. The direct and indirect costs of AD and other dementias amount to more than €440,000 million each year (www.alz.org, 2010).Even modest therapeutic advances that delay disease onse ...
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 17

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Training network for developing innovative (bio)artificial devices for treatment of kidney and liver disease (BIOART)

Start date: Dec 1, 2012, End date: Nov 30, 2016,

Renal and liver diseases are global public health problems, with the incidences of end-stage renal disease (ESRD) and end-stage liver disease (ESLD) rising annually. Due to the lack of donor kidneys, most of ESRD patients depend on dialysis treatment using either an artificial kidney or the peritoneal membrane. Both modes are inefficient in removing uremic waste molecules and inadequately remove e ...
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 12

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Patient-centered palliative care pathways in advanced cancer and chronic disease (INSUP-C)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

Integrated delivery systems of care, e.g. networks of health organizations and professionals who work together to coordinate services to meet their patients’ needs, are an important way of linking fragmented services and maximizing system efficiency and seamlessness of patient transition. Research increasingly shows that patients with advanced cancer and advanced chronic disease are treated well ...
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 11

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Observational Prolonged Trial In Myotonic dystrophy type 1 to Improve QoL-Standards, a Target Identification Collaboration (OPTIMISTIC)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

OPTIMISTIC is a proposal for a European collaborative project of doctors, scientists, relevant stakeholders (TREAT-NMD, patient organizations) and SMEs with the aim to improve clinical practice for patients suffering from a rare, inherited, and neglected disease, myotonic dystrophy type 1 (DM1). It is one of the most variable human diseases with complex, multi-systemic and progressively worsening ...
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 9

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Advanced photonic antenna tools for biosensing and cellular nanoimaging (NANO-VISTA)

Start date: Nov 1, 2011, End date: Oct 31, 2016,

Advances in the fields of molecular and cell biology are strongly coupled to the implementation of photonic tools that allow highly-sensitive measurements in living cells at high molecular concentrations and at the nanometre scale. The goal of NANO-VISTA is to exploit novel concepts of photonic antennas to develop a new generation of bionanophotonic tools for ultrasensitive detection, nanoimaging ...
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 7

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Clinical Officer Surgical Training in Africa (COST - Africa)

Start date: Apr 1, 2011, End date: Sep 30, 2016,

Obstetrical and abdominal emergencies, and trauma, much of it affecting children, represent a major and neglected part of Africa’s burden of disease. Countries cannot train and retain sufficient specialist surgeons (doctors) to address these priorities. We propose a surgical training intervention targeted at Clinical officers (COs), who are trained non-physician clinicians that form the backbone o ...
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 4

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International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research (INTREALL)

Start date: Oct 1, 2011, End date: Sep 30, 2016,

Though survival of children with acute lymphoblastic leukaemia (ALL) has improved, relapse remains a leading cause of mortality in childhood cancer. Given the rarity of the disease, only a large international cooperative group can recruit sufficient patients for prospective studies with specific questions in biologic subgroups. Under the umbrella of the I-BFM SG all relevant mainly European study ...
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 29

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Focused ultrasound under magnetic resonance guidance for targeted drug delivery in the brain (MRGFUS IN THE BRAIN)

Start date: Sep 1, 2013, End date: Aug 31, 2016,

Patients with brain tumours have limited treatment options and could benefit from new treatments. Focused ultrasound (FUS) combined with a microbubble agent, under guidance of magnetic resonance (MR) imaging, has been used in animal studies to temporarily open the blood-brain-barrier (BBB). The BBB normally protects the brain by blocking most substances from the blood and is a hurdle to the use of ...
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 1

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A Generic Open-end Simulation Environment for Minimally Invasive Cancer Treatment (Go-Smart)

Start date: Apr 1, 2013, End date: Jun 30, 2016,

The Go-Smart project will build a generic open-source software simulation environment for planning of image guided percutaneous Minimally Invasive Cancer Treatment (MICT). MICT includes radiofrequency ablation (RFA), cryoablation, microwave ablation (MW), transarterial chemoembolisation (TACE), brachytherapy (BT), and prospectively, irreversible electroporation (IRE). Beside of TACE each type of M ...
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 9

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European Network for the Study of Adrenal Tumours - Structuring clinical research on adrenal cancers in adults (ENS@T-CANCER)

Start date: Jan 1, 2011, End date: Jun 30, 2016,

Among patients with adrenal masses Adrenocortical carcinoma (ACC) and malignant pheochromocytomas (MPH) are found with a low incidence but very unfavorable prognosis. Due to this poor clinical outcome, concomitant hormone dysregulation and limited treatment options the two cancer entities severely impact on affected patients. However, the rarity of the tumors also impedes clinical studies which ar ...
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 17

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The neurobiology of schemas: knowledge acquisition and consolidation (NEUROSCHEMA)

Start date: Jun 1, 2011, End date: May 31, 2016,

"This Co-Investigator Application is an interdisciplinary experimental analysis of the neurobiological mechanisms by which we acquire knowledge. Our approach builds on the foundations of contemporary cognitive neuroscience, particularly ideas about the neural mechanisms of declarative memory, and upon recent findings of the participating laboratories (Morris, Fernández) that have each addressed ke ...
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 2

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OSTEOIMMUNE - Unraveling the Interactions between the Immune System and Bone (OSTEOIMMUNE)

Start date: Jun 1, 2012, End date: May 31, 2016,

Inflammatory rheumatic diseases affect millions of European citizens causing chronic pain, disability and premature death. Curative treatments are lacking. Conventional research often focuses on one single organ system such as the bone or the immune system and. ignores interactions between organ systems. OSTEOIMMUNE is a supra-disciplinary training network that targets this gap by providing compre ...
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 12

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Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects (ADDUCE)

Start date: Nov 1, 2010, End date: Apr 30, 2016,

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children, affecting approximately 5% children in Europe. Methylphenidate (MPH) is the most-commonly prescribed medication for ADHD children; it is also increasingly used in ADHD adults. In 2007, the European Commission requested a referral to the Committee for Medicinal Products for Human Use ...
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 17

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New Models for Preclinical Evaluation of Drug Efficacy in Common Solid Tumours (PREDECT)

Start date: Feb 1, 2011, End date: Apr 30, 2016,

Traditional preclinical discovery methods, particularly for target validation, poorly predict drug efficacy, causing a high attrition rate in costly late-stage clinical trials. The PREDECT consortium will focus on complex but transferable, next generation in vitro and in vivo models for breast, prostate and lung cancers. Models will be investigated for their improved potential to validate novel th ...
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 23

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Virtual Physiological Human: Personalized Predictive Breast Cancer Therapy Through Integrated Tissue Micro-Structure Modeling (VPH-PRISM)

Start date: Mar 1, 2013, End date: Feb 29, 2016,

Description Personalised predictive modelling of breast cancer allows treatment stratification, preventing unnecessary and unsuccessful treatments. VPH-PRISM (Virtual Physiological Human: Personalized Predictive Breast Cancer Therapy through Integrated Tissue Micro-Structure Modeling) addresses these key topics with integrated multidisciplin ...
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 9

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Integrated health technology assessment for evaluating complex technologies (INTEGRATE-HTA)

Start date: Jan 1, 2013, End date: Dec 31, 2015,

"The rise of complex, chronic diseases in an ageing European population led to the development of increasingly complex technologies. Current HTA is not well equipped to assess complex technologies due to a lack of attention to the diversity in patient characteristics and patient preferences, the limited consideration of context and implementation issues, and missing strategies to integrate all the ...
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 7

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"Self-care Support for People with Long Term Conditions, Diabetes and Heart Disease: A Whole System Approach" (EU-WISE)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

"The overall aim of this project is to offer a deeper understanding of the different mechanisms involved in the management of chronic conditions with a specific focus on how initiatives are translated and embedded into the illness management practices in peoples’ everyday life. It is in work, domestic and community settings where these practices are shaped by the emotional, symbolic, ethical, eco ...
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 10

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Virtual reality-Treadmill combined Intervention for enhancing Mobility and reducing falls in the Elderly (V-TIME)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

"Falls are a major public health concern that directly affects millions of elderly Europeans, the healthcare system, and the adult children and caregivers of older people. The V-TIME approach combines cutting edge technology with emerging concepts from gerontology, neuroscience and rehabilitation to reduce fall risk in a unique way. The V-TIME multi-modal intervention consists of treadmill traini ...
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 9

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European Training Network for Excellence in Molecular Imaging in Diabetes (BETATRAIN)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

Currently, 180 million people suffer from diabetes worldwide and this number is expected to double until 2030. Diabetes-related healthcare costs may rise to 40% of the total healthcare budget in high incidence countries. Despite these daunting numbers, our knowledge about the pathophysiology of T1D and T2D remains limited and many questions about the relation of the of the beta cell mass, the beta ...
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 10

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EUROpean consortium for antiCALINs as next generation high-affinity protein therapeutics (EUROCALIN)

Start date: Aug 1, 2011, End date: Nov 30, 2015,

The consortium aims to develop and produce an Anticalin, a member of a novel high-affinity scaffold derived from the lipocalin protein family. The Anticalin is specific for hepcidin which is a central regulator of iron homeostasis, and will be used to antagonize hepcidin for the treatment of “anemia of chronic disease” (ACD). Anticalins are genetically modified lipocalins that can target almost an ...
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 11

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Suicidality: Treatment Occurring in Paediatrics (STOP)

Start date: Nov 1, 2010, End date: Apr 30, 2015,

The emergence of suicidality in patients receiving drug treatment is of concern because of the overall burden and the possible link with completed suicide. The lack of uniform requirements for defining, detecting and recording suicidality and the presence of disease related confounders create major problems. It is possible that Medication-Related Suicidality (MRS) differs from Psychopathology-Rela ...
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 19

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Paediatric European Risperidone Studies (PERS)

Start date: May 1, 2010, End date: Apr 30, 2015,

"Second-generation antipsychotics are increasingly being prescribed to children and adolescents. Their use, however, is mostly off-label, and adequate and sufficient data about efficacy and particular safety are lacking. This proposal focuses on two indications, the use of risperidone in children and adolescents with conduct disorder who are not mentally retarded, and the use of risperidone in ado ...
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 22

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REsearch into implementation STrategies to support patients of different ORigins and language background in a variety of European primary care settings (RESTORE)

Start date: Apr 1, 2011, End date: Mar 31, 2015,

This project is concerned with optimising the delivery of primary healthcare to European citizens who are migrants who experience language and cultural barriers in host countries. We focus on the implementation of evidence-based health information (e.g. guidelines to enhance communication in cross-cultural consultations) and interventions (e.g. training initiatives on interculturalism and the use ...
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 8

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Tailored implementation for chronic diseases (TICD)

Start date: Feb 1, 2011, End date: Feb 28, 2015,

Project aim. Chronic diseases represent an important challenge facing healthcare systems. Research has consistently shown gaps between knowledge and practice for chronic illness care. Tailoring implementation interventions implies that the choice and content of implementation interventions are based on assessment of local barriers and enabling factors. It is widely believed that tailoring contribu ...
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 7

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IMplementation of quality indicators in PAlliative Care sTudy (IMPACT)

Start date: Feb 1, 2011, End date: Jan 31, 2015,

"New knowledge is not necessarily readily applied in medicine, even when there is evidence of its effectiveness. As a result of the gap between knowing and doing, policy makers, professional care providers, patients and their families have benefited too little from new developments. Implementation research has developed models for stepwise implementation but it is still unclear which strategies ar ...
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 14

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Cadherin control of invasive growth in morphogenesis and cancer (CCinG)

Start date: Jan 1, 2013, End date: Dec 31, 2014,

Cadherin-based cell-cell junctions regulate tissue architecture by coordinating multicellular growth and polarity. In addition to the ubiquitously expressed and widely studied E-cadherin, epithelia express other, more tissue-specific classical cadherins, often particularly during developmental epithelial rearrangements. These additional cadherins recently also have been implicated in tumor progr ...
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 1

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Optimizing delivery of health care interventions (ODHIN)

Start date: Jan 1, 2011, End date: Dec 31, 2014,

ODHIN is a Europe wide project involving research institutions from nine European countries that will help to optimize the delivery of health care interventions by understanding how better to translate the results of clinical research into every day practice. ODHIN will use the implementation of identification and brief intervention (IBI) programmes for hazardous and harmful alcohol consumption (H ...
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 21

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Long-term PHARMacovigilance for Adverse effects in Childhood arthritis focussing on Immune modulatory drugs (PHARMACHILD)

Start date: Apr 1, 2011, End date: Sep 30, 2014,

Until the age of biotechnology, treatment options for children and adolescents with severe arthritis, inflammatory bowel diseases and other serious diseases with chronic inflammation were limited. Advances in understanding the pathophysiology of the inflammatory responses have led to the development of a new class of medications that are capable of inhibiting selectively the principal mediators of ...
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 9

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RNA-DIRECTED EPIGENETIC REMODELLING IN CANCER (RNA-DIREC)

Start date: Sep 1, 2010, End date: Aug 31, 2014,

"Epigenetics describes the modification of gene expression without changing the DNA sequence. It is now well established that epigenetics plays a major role in cancer development. The Clark lab in which Dr. Coolen currently works (Sydney, Australia), has discovered that such epigenetic changes in cancer are not always localised to individual genes, but can encompass large chromosomal regions resul ...
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 1

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ADIPOSE DERIVED STROMAL CELLS FOR OSTEOARTHRITIS (ADIPOA)

Start date: Jan 1, 2010, End date: Jun 30, 2014,

Osteoarthritis (OA) is a degenerative joint disease for which no efficient therapy is available. The ADIPOA consortium has previously shown that intraarticular injections of stromal cells prevents OA in two different models, but the mechanisms of this chondroprotective effect remains unknown, and the activation of cartilage derived endogenous stem cells is suspected. The participants have experien ...
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