Search for European Projects

6 European Projects Found

Searched on 125080 European Projects

 FINISHED 

EURopean Endeavour for Chimeric Antigen Receptor Therapies (EURE-CART)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Cancer is rapidly becoming the most frequent cause of death in EU. Though enormously expensive (several billions EUR/year), currently available anti-cancer therapies are major causes of chronic diseases. Adoptive immunotherapy with T cells genetically modified with a tumour-reactive chimeric antigen receptor (CAR) is an innovative therapeutic concept, promising to eradicate cancer without causing ...
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 11

 FINISHED 

Towards clinical translation of new gene targeting technologies for correcting inherited mutations and empowering adoptive immunotherapy of cancer (SUPERSIST)

Start date: May 1, 2013, End date: Oct 31, 2016,

Substantial evidence supports the therapeutic potential of ex vivo gene therapy based on Hematopoietic Stem Cell (HSC) or T lymphocytes to treat inherited diseases or cancer. Yet, the intrinsic limitations of current gene replacement approaches based on semi-randomly integrating vectors, and the occurrence in some clinical trials of severe adverse events related to gene transfer, prevent safe depl ...
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 5

 FINISHED 

Advanced Cell-based Therapies for the treatment of Primary ImmunoDeficiency (CELL-PID)

Start date: Nov 1, 2010, End date: Apr 30, 2016,

Primary immune deficiencies (PID) are inherited disorders of the adaptive and innate immune system marked by severe infections, autoimmunity and high risk of cancer. Treatment entails hematopoietic stem cell (HSC) transplantation from allogeneic donors, however in the absence of an HLA compatible donor, HSCT outcome is limited by delayed or suboptimal reconstitution and complications. SCID-X1 and ...
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 20

 FINISHED 

Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases (OptiStem)

Start date: Jan 1, 2009, End date: Dec 31, 2013,

...facilities increases performance and reduces costs. Based on these considerations, a network of internationally recognized experts in muscle and epithelial cell biology, immunology, angiogenesis, and molecular pharmacology with two stem cell-based Companies has been assembled, creating a synergistic approach that will increase the chance of success for ongoing and future clinical trials with stem ...
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 20

 FINISHED 

Advanced Teaching and TRaining for Adoptive Cell Therapy (ATTRACT)

Start date: Oct 1, 2009, End date: Sep 30, 2013,

Considerable resources are devoted to fighting cancer throughout Europe, yet these efforts are not producing the results that health practitioners and citizens might expect. This is partly due to the fragmentation and duplication of research efforts within Member states and the lack of co-ordination at European level. However it can also be attributed to the need to retain and most importantly dev ...
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 16

 FINISHED 

Persisting Transgenesis (PERSIST)

Start date: Jan 1, 2009, End date: Jun 30, 2013,

"For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize ...
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