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Inhibiting Nef: a novel drug target for HIV-host interactions (iNEF)
Start date: Jan 1, 2008, End date: Jun 30, 2011,
Although HIV-1 Nef was originally named "negative factor," it has been shown to be critical for efficient persistance of HIV-1 infected humans thus playing a major role in the progression to AIDS. Remarkably; until now Nef has not been evaluated as an antiretroviral drug target. It is well established that Nef promotes HIV-1 replication and facilitates viral immune evasion by interacting with vari ...
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