Search for European Projects

26 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor ...
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 25

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Post-transcriptional Regulation of Germinal Center B Cell Responses in Immunity and Disease (GCB-PRID)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

Antibodies secreted by B cells of the adaptive immune system establish an essential barrier against bacteria and viruses and their presence is the hallmark of protective vaccinations. B cells are licensed for their tasks during germinal center (GC) reactions and differentiation into antibody-secreting plasma cells. Unfortunately, B cell-derived autoantibodies and proinflammatory cytokines can caus ...
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 2

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Dissecting the role of the ubiquitin proteasome system in the pathogenesis and therapy of B-cell malignancies (BCM-UPS)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

B-cell malignancies are characterized by high levels of genomic instability, which critically contribute to their pathogenesis and evolution. Recently, the fundamental role of the ubiquitin proteasome system (UPS) in maintaining genome integrity has been appreciated. Two major new therapeutic modalities in B-cell malignancies, proteasome inhibitors and imunomodulatory drugs (IMiDs), target the UPS ...
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 2

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Individualised medicine in chronic inflammatory skin diseases (IMCIS)

Start date: Jul 1, 2016, End date: Jun 30, 2021,

More than 100 million EU citizens suffer from chronic inflammatory skin diseases such as psoriasis and atopic eczema (AE). The diseases imply a devastating life quality similar to that of cancer, and cause direct socio-economic costs in the magnitude of 100 billion Euro each year in the EU. Despite all efforts, psoriasis and AE remain undertreated and the concept of individualised (also called pre ...
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 2

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Magnetic resonance imaging platform for probing fat microstructure (ProFatMRI)

Start date: Apr 1, 2016, End date: Mar 31, 2021,

Metabolic syndrome and osteoporosis are the two metabolic diseases with the highest and most rapidly growing prevalence, transforming them into a major global health and socioeconomic concern. Metabolic syndrome can be diagnosed with established biomarkers, but the selection of optimal prevention strategies for each individual patient is still problematic. Osteoporosis can be treated, but its curr ...
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 2

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Next-generation in vivo models for improved pancreatic cancer therapies (PanCaT)

Start date: Feb 1, 2016, End date: Jan 31, 2021,

Maintenance and drug resistance of pancreatic ductal adenocarcioma (PDAC) depends on cancer cell intrinsic mechanisms and a stroma that supports tumor growth. Mouse models of human PDAC have provided important insights into the evolution of this highly lethal tumor, but there are no models that allow secondary genetic manipulation of autochthonous tumors, the tumor microenvironment or the metastat ...
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 2

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Small vessel diseases in a mechanistic perspective: Targets for InterventionAffected pathways and mechanistic exploitation for prevention of stroke and dementia (SVDs-at-target)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical prese ...
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 14

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Light induced spatially EXact and genetically encoded labeling of immune cells for monitoring of lOng Distance and Ultra-compartment Shuttling during autoimmunity and chronic inflammation (EXODUS)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

The incidence of autoimmune diseases including multiple sclerosis is dramatically increasing. While there is a genetically defined “bedrock” susceptibility to develop T cell mediated autoimmunity, environmental cues likely determine the threshold for disease development. Yet, little is known on how environmental cues sensed at body/environment interfaces are translated into immunopathology in dist ...
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 2

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Individualized treatment planning in chronic back pain patients by advanced imaging and multi-parametric biomechanical models (iBack)

Start date: Jun 1, 2015, End date: May 31, 2020,

Chronic back pain is a major burden and source of disability worldwide. It is primarily attributed to biomechanical factors. In elderly patients, osteoporosis complicates the biomechanical scenario. Surgery is often required to treat instability-related pain and to restore the balance of the spine. However, when and how to perform surgery remains a highly subjective decision based on the surgeon’s ...
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 3

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Autologous Stem Cell Seeded Tissue Engineered Trachea (TETRA)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

CLINICAL PROBLEM AND UNMET NEEDThere are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic trac ...
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 14

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Platform for Open Development of Systems of Artificial Intelligence (Bonseyes)

Start date: Dec 1, 2016, End date: Nov 30, 2019,

The Bonseyes project aims to develop a platform consisting of a Data Marketplace, Deep Learning Toolbox, and Developer Reference Platforms for organizations wanting to adopt Artificial Intelligence in low power IoT devices (“edge computing”), embedded computing systems, or data center servers (“cloud computing”). It will bring about orders of magnitude improvements in efficiency, performance, reli ...
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 15

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Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer (CAM-PAC)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from di ...
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 18

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Schizophrenia Psychological Interventions Network Meta-Analysis of randomized evidence (SPIN-MA)

Start date: Oct 1, 2016, End date: Sep 30, 2018,

...able knowledge for making decisions according to an evidence based medicine approach. This addresses several EU programs’ aims. I will be hosted at the Department of Psychiatry and Psychotherapy of Klinikum rechts der Isar der Technischen Universität München, under the supervision of Professor Stefan Leucht, who has outstanding expertise both in the field of schizophrenia treatment and in the meth ...
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 2

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implementAtion anD OPeration of the gateway for healTh into BBMRI-ERIC (ADOPT BBMRI-ERIC)

Start date: Oct 1, 2015, End date: Sep 30, 2018,

"BBMRI-ERIC: the Biobanking and BioMolecular resources Research Infrastructure - European Research Infrastructure Consortium, aims to establish, operate and develop a Pan-European distributed research infrastructure in order to facilitate the access to biological resources as well as facilities and to support high quality biomolecular and biomedical research. The ADOPT BBMRI-ERIC proposal aims at ...
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 22

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Statistical multi-Omics UNDerstanding of Patient Samples (SOUND)

Start date: Sep 1, 2015, End date: Aug 31, 2018,

Bioinformatic analysis is the biggest bottleneck in many genomic medicine projects. Our objective is to enable researchers to dramatically increase statistically informed use of personal multi-omic data in medicine. Soon, multiple types of omic technologies will be applied to 100,000s of patient-derived samples, with the three-stage goal of better understanding disease biology, discovery of new in ...
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 11

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Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope (EU-CERT-ICD)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and cos ...
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 27

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Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure (OptimEx)

Start date: Oct 1, 2013, End date: Mar 31, 2017,

More than 14 million Europeans suffer from heart failure (HF), of which more than 50 % have HF with preserved left ventricular (LV) ejection fraction (EF) (HFPEF, “diastolic heart failure”). HFPEF is the only cardiovascular disease with increasing prevalence and incidence, affecting 10-20% of the elderly and contributing substantially to hospitalizations of elderly HF patients. Currently, no medic ...
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 9

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Anti-Biopharmaceutical Immunization:Prediction and analysis of clinical relevance to minimize the risk (ABIRISK)

Start date: Mar 1, 2012, End date: Feb 28, 2017,

The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recru ...
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 39

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Improving HSCT By Validation Of Biomarkers & Development Of Novel Cellular Therapies (CELLEUROPE)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

Novel transplant regimens are currently being developed to improve beneficial GvL effects and reduce GvHD and infections via several new forms of cellular therapies. This newly emerging supra-disciplinary field of cellular therapy and regenerative medicine is also being used to improve outcomes in autoimmune disease (such as Rheumatoid Arthritis) and cancers. The goal of this research programme is ...
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 13

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Treat Iron-Related Childhood-Onset Neurodegeneration (TIRCON)

Start date: Nov 1, 2011, End date: Oct 31, 2015,

Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of rare hereditary neurodegenerative disorders characterized by high levels of brain iron. The most common form is pantothenate kinase-associated neurodegeneration (PKAN). Classic PKAN and most other NBIA cases are characterised by early childhood onset and rapid progression. Currently, there is no proven therapy to hal ...
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 14

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Novel multimodal endoscopic probes for simultaneous PET/ultrasound imaging for image-guided interventions (ENDOTOFPET-US)

Start date: Jan 1, 2011, End date: Jun 30, 2015,

In the frame of this project it is proposed to define and build a bi-modal PET-US (Positron Emission Tomography and Ultrasound) endoscopic probe combining in a miniaturized system a fully digital, 200ps time resolution Time of Flight PET detector head (TOF-PET) coupled to a commercial ultrasound (US) assisted biopsy endoscope and to launch the first steps of clinical validation.The project address ...
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 16

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Targeting the tumour microenvironment to improve pancreatic cancer prognosis (EPC-TM-Net)

Start date: Feb 1, 2011, End date: Jul 31, 2014,

Pancreatic cancer is one of the most lethal human cancers with a five-year survival rate of less than 5%. Late presentation and a high level of resistance to chemotherapeutic drugs are among the major reasons for this dismal prognosis. The presence of the highest degree of desmoplasia among all solid tumours and the fact that chronic inflammatory pancreatic disease is associated with an increased ...
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 17

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Embryonic Stem cell-based Novel Alternative Testing Strategies (ESNATS)

Start date: Apr 1, 2008, End date: Sep 30, 2013,

"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to ...
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 34

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CAMbrella – A pan-European research network for Complementary and Alternative Medicine (CAM) (CAMbrella)

Start date: Jan 1, 2010, End date: Dec 31, 2012,

The goal of this collaboration is to develop a roadmap for future European research in CAM that is appropriate for the health care needs of EU citizens, and acceptable to the EU parliament as well as their national research funders and healthcare providers. We will enable meaningful reliable comparative research and communication within Europe and create a sustainable structure and policy. CAMbrel ...
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 17

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Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease (EVINCI-study)

Start date: Jan 1, 2009, End date: Jun 30, 2012,

The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumora ...
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 22

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The mechanisms of cardiovascular risks after low radiation doses (CARDIORISK)

Start date: Feb 1, 2008, End date: Jun 30, 2011,

"Recent epidemiologic evidence suggests that moderate and low radiation doses to the heart may result in a moderate, but significant increase in cardiovascular mortality. So far, the pathogenesis of radiation induced heart disease has not been studied in detail. Pathohistologic studies suggest that microvascular damage plays a crucial role in the development of radiation induced cardiovascular dis ...
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 14