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Facilitating Implementation of Research Evidence (FIRE) is a proposed four year programme of research to identify and validate key factors determining the successful implementation of research evidence in practice. The study is underpinned by a conceptual framework, the Promoting Action on Research Implementation in Health Services (PARiHS) framework, which proposes that the successful implementat ...

The symptoms of complex disease like allergy, obesity and cancer depend on the products of multiple interacting genes. High-throughput techniques have implicated hundreds of genes. There are also considerable individual variations. A clinical implication of this may be inadequate treatment response, which is increasingly recognized as a cause of increased suffering and costs. Ideally, physicians s ...