3 European Projects Found
Searched on 125080 European Projects
FINISHED
Tumour Heterogeneity and Somatic Evolution of Unstable cancer genomes (THESEUS)
Start date: Jun 1, 2014, End date: May 31, 2019,
SummaryThe majority of metastastic solid tumours remain incurable. In-depth analysis of tumour genomes is revealing evidence for branched evolution and cancer subclonal spatial and temporal intratumour heterogeneity (ITH). Drivers of ITH such as chromosomal instability (CIN) are associated with drug resistance and poor clinical outcome. However, despite increasing knowledge of tumour diversity, th ...
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3
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Mapping the Targets of Antimalarial Compounds Through Chemical Profiling (MALARIA TARGETS ID)
Start date: Sep 1, 2014, End date: Aug 31, 2018,
Malaria is one of the most devastating infectious diseases affecting half of the world population and killing close to a million people every year. Widespread resistance of the malaria parasite to most front-line drugs and the rapid emergence of resistance against new therapies have made the validation of novel pharmaceutical targets and the identification of potent pharmacophores extremely urgent ...
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2
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The impact of chromosomal instability on health: Molecular causes and consequences of aneuploidy (PLOIDYNET)
Start date: Oct 1, 2013, End date: Sep 30, 2017,
Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than s ...
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