Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Federation for FIRE Plus (Fed4FIREplus)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

The Fed4FIRE+ project has the objective to run and further improve Fed4FIRE’s “best-in-town” federation of experimentation facilities for the Future Internet Research and Experimentation initiative. Federating a heterogeneous set of facilities covering technologies ranging from wireless, wired, cloud services and open flow, and making them accessible through common frameworks and tools suddenly op ...
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 24

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Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in ...
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 17

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Institut Curie 3-i PhD Program (IC-3i-PhD)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

The new IC-3i-PhD program of Institut Curie and its partners will produce top-level scientific knowledge by promoting basic interdisciplinary research that will be translated into novel therapeutic avenues for diagnosis and treatment. The completely re-structured, revitalized, and ambitious international “Triple i” PhD program is strengthened by trans- and inter-disciplinary and inter-sectorial re ...
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 1

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Chromatin Adaptations through Interactions of Chaperones in Time (ChromADICT)

Start date: Jul 1, 2016, End date: Jun 30, 2021,

A central question in chromatin biology is how to organize the genome and mark specific regions with histone variants. Understanding how to establish and maintain, but also change chromatin states is a fundamental challenge. Histone chaperones, escort factors that regulate the supply, loading, and degradation of histone variants, are key in their placement at specific chromatin landmarks and bridg ...
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 1

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New therapies for uveal melanoma (UM Cure 2020)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Uveal melanoma (UM) is a rare intraocular tumour with an incidence of 5 cases per million individuals per year. Up to 50% of UM patients develop metastases, most often in the liver, and these are invariably fatal. Despite new discoveries in the genetic and molecular background of the primary tumour, little is known about the metastatic disease; furthermore, there is no therapy to either prevent or ...
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 13

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Exploring mechanisms of gene repression and escape during X-chromosome inactivation (XPRESS)

Start date: Nov 1, 2015, End date: Oct 31, 2020,

During mammalian development, precise gene expression patterns have to be established and then maintained, or reversed, in different cellular and tissue contexts. A striking example of such developmentally regulated gene control is X-chromosome inactivation (XCI), whereby one of the two X chromosomes in females is silenced during embryogenesis. XCI is initiated by the non-coding Xist RNA, which co ...
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Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES) (BRIDGES)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

Breast cancer affects more than 360,000 women per year in the EU and causes more than 90,000 deaths. Identification of women at high risk of the disease can lead to disease prevention through intensive screening, chemoprevention or prophylactic surgery. Breast cancer risk is determined by a combination of genetic and lifestyle risk factors. The advent of next generation sequencing has opened up th ...
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Unravelling the Genomic Targets of Drugs Using High-Throughput Sequencing (Drug-Seq)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

This proposal is centred on the development of small molecule probes derived from DNA damaging agents to identify their genomic targets using a novel unbiased approach. Although, several genotoxic drugs have been used for decades to treat cancers, the exact mechanisms by which they operate are not fully understood. It is established that these compounds interfere with the processes of transcriptio ...
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 1

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European Joint Programme for the Integration of Radiation Protection Research (CONCERT)

Start date: Jun 1, 2015, End date: May 31, 2020,

The proposed European Concerted Programme on Radiation Protection Research (acronym: CONCERT) aims to contribute to the sustainable integration of European and national research programmes in radiation protection. It will do so by focusing resources and efforts in five key directions:• Bring together the elements of the European scientific communities in the fields of radiation effects and risks, ...
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 36

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Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease: a multicentric, parallel-group, placebo-controlled, randomized clinical trial of deferiprone (FAIR-PARK-II)

Start date: May 1, 2015, End date: Apr 30, 2020,

Parkinson’s disease (PD) is a major, chronic, non-communicable disease and the 2nd most frequent neurodegenerative disorder worldwide. Excess iron is primarily detected in the substantia nigra pars compacta, where dopaminergic neurons are exposed to high levels of oxidative stress produced by mitochondrial disorders and dopamine metabolism. Our previous preclinical, translational and pilot clinica ...
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 17

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Water-mass transformation and Pathways In The Weddell Sea: uncovering the dynamics of a global climate chokepoint from In-situ measurements (WAPITI)

Start date: May 1, 2015, End date: Apr 30, 2020,

Deep water formed around the Antarctic continent drives the world ocean circulation. 50-70% of this deep water is formed within only about 10% of the Antarctic circumpolar band: the Weddell Sea. Subtle changes in the circulation of the Weddell Sea can lead to major changes in floating ice-shelves, with critical implications for global sea-level, the production of deep water and the global ocean ov ...
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 2

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A multidisciplinary approach to cell division: From human oocyte to synthetic biology (DivIDe)

Start date: Apr 1, 2016, End date: Mar 31, 2020,

The cell is the universal unit of living matter, and there cannot be propagation of life without cell division. DivIDe aims to investigate the mechanisms and principles of cell division and to reproduce them in vitro with synthetic approaches. Crucial to cell division is the mitotic spindle, a structure whose main duty is the separation of chromosomes. The spindle is made of microtubules (MT), mol ...
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 9

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Hijacking cell signalling pathways with magnetic nanoactuators for remote-controlled stemcell therapies of neurodegenerative disorders (MAGNEURON)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

Neurodegenerative diseases, such as Parkinson’s disease, are a major public health issue given the aging population in Europe and beyond. While curative pharmacological treatment of these diseases is not in sight, cell replacement therapies (CTs) are considered very promising, in particular with the advent of stem-cell reprogramming technologies. However, a fundamental challenge in the medical app ...
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 6

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Cancer treatment and monitoring through identification of circulating tumour cells and tumour related nucleic acids in blood (CANCER-ID)

Start date: Jan 1, 2015, End date: Dec 31, 2019,

Blood-based biomarkers such as Circulating Tumor Cells (CTCs), circulating free tumor DNA (cfDNA) and microRNAs (miRNAs) have the potential to improve the development of personalized medicines for cancer patients. This is of particular importance when biopsies of the primary tumor or metastases are not accessible (e.g. at early disease stages or in minimal residual disease) or possible and the ass ...
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Dark matter of the human transcriptome: Functional study of the antisense Long Noncoding RNAs and Molecular Mechanisms of Action (DARK)

Start date: Dec 1, 2014, End date: Nov 30, 2019,

98% of the human genome is non-protein coding raising the question of the role of the dark matter of the genome. It is now admitted that pervasive transcription generates thousands of noncoding transcripts that regulate gene expression and have broad impacts on development and disease. Among the long non coding (lnc)RNAs, antisense transcripts have been poorly studied despite their putative regula ...
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A training network for the chemical site-selective modification of proteins: Preparation of the next-generation of therapeutic chemically-defined protein conjugates (ProteinConjugates)

Start date: Nov 1, 2015, End date: Oct 31, 2019,

ProteinConjugates is an inter- and multi-disciplinary network for the education of talented young scientists who will learn how to rationally design and construct the next generation of chemically-defined and innovative protein drug-conjugates for the targeted treatment of serious conditions such as cancer or rheumatoid arthritis. A complementary interaction between academy and pharmaceutical indu ...
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 8

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Principles of Polarity – Integrating genetic, biophysical and computational approaches to understand cell and tissue polarity (PolarNet)

Start date: Oct 1, 2015, End date: Sep 30, 2019,

The ability of cells to polarize underlies the most basic biological functions such as motility and response to external challenges, but also the formation and maintenance of tissues in a multicellular organism. The importance of cell polarity is underscored by the fact that cell polarity is essential for animal development and is perturbed in disease states such as cancer. Understanding cell pola ...
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 9

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Phagosome functions and antigen cross presentation in primary dendritic cells (DCBIOX)

Start date: Sep 1, 2014, End date: Aug 31, 2019,

T cell cross priming (the initiation of CD8+ T cell responses to antigen that are not expressed by dendritic cells, DCs) requires the phagocytosis of antigens by DCs and their presentation on MHC class I molecules, a process referred to as “cross presentation”. Here, we propose a series of integrated approaches to address the most fundamental mechanisms of cross presentation and explore the use of ...
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Optimizing and Enhancing the Integrated Atlantic Ocean Observing System (AtlantOS)

Start date: Apr 1, 2015, End date: Jun 30, 2019,

...promote innovation, documentation and exploitation of innovative observing systems. All AtlantOS work packages will strengthen the trans-Atlantic collaboration, through close interaction with partner institutions from Canada, United States, and the South Atlantic region. AtlantOS will develop a results-oriented dialogue with key stakeholders communities to enable a meaningful exchange between the ...
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European Marine Biological Research Infrastructure Cluster to promote the Blue Bioeconomy (EMBRIC)

Start date: Jun 1, 2015, End date: May 31, 2019,

Marine (blue) biotechnology is the key to unlocking the huge economic potential of the unique biodiversity of marine organisms. This potential remains largely underexploited due to lack of connectivity between research services, practical and cultural difficulties in connecting science with industry, and high fragmentation of regional research, development and innovation (RDI) policies. To overcom ...
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Epigenetic Control of Mammalian Reproduction (EPIREPRO)

Start date: Jun 1, 2014, End date: May 31, 2019,

By standing at the crossroads of generations, germ cells ensure species continuity. At the time of fertilization, the oocyte and spermatozoon carry the genetic material but also non-genetically encoded, epigenetic information. Gametic epigenetic modifications have immediate effects on gametic production and fertility. They also have long-term consequences on somatic phenotypes when transmitted to ...
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Characterizing Atrial fibrillation by Translating its Causes into Health Modifiers in the Elderly (CATCH ME)

Start date: May 1, 2015, End date: Apr 30, 2019,

Atrial fibrillation (AF) is the most common cardiac arrhythmia, with a prevalence of 1.5-2% in European populations. By being a major cause of stroke, dementia, heart failure, and premature death, AF is a major threat to healthy ageing. Despite increasing knowledge on the diverse mechanisms that cause the AF substrate in individual patients, current strategies for prevention and therapy of AF rema ...
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 9

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Endocytic Membrane Compartmentalization by Galectins (GALECTCOMPART)

Start date: Apr 1, 2014, End date: Mar 31, 2019,

The contribution of clathrin-independent endocytosis to the cellular entry of signaling receptors, cell adhesion factors, and other cell surface molecules is well documented. However, how this process is initiated is still unknown. We have recently found that a cellular lectin, galectin-3 (Gal3), entered cells via morphologically distinct tubular structures, so-called clathrin-independent carriers ...
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 2

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Leading Innovative measures to reach gender Balance in Research Activities (LIBRA)

Start date: Oct 1, 2015, End date: Mar 31, 2019,

The main goals of LIBRA are to implement innovative Gender Equality Plans (GEPs) that will empower women researchers to achieve successful careers in science, remove gender barriers and biases at an institutional level, and raise awareness of gender aspects in the experimental design of pre-clinical research projects. To achieve these goals we will: 1) conduct an initial external assessment of eac ...
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Morphogenesis of proliferative epithelial tissue (TIMORPH)

Start date: Mar 1, 2014, End date: Feb 28, 2019,

Shape is a conspicuous and fundamental property of living multicellular organisms. Questions related to embryo shape or morphogenesis have naturally haunted developmental biologists for decades. Recent advances have highlighted that the understanding of the morphogenesis of proliferative tissue will require (i) the dissection of how subcellular cytoskeleton dynamics controls cellular processes suc ...
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 1

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Radiation Innovations for Therapy and Education (RADIATE)

Start date: Mar 1, 2015, End date: Feb 28, 2019,

Approximately 45-60% of all cancer patients are treated with radiotherapy. Some of these patients have a good outcome, but in other cases their illness fails to be cured. This may result from distant metastases or from regrowth of the primary tumor. This training network is built on the premise that considerable advances in understanding radiobiology will open novel routes for effective therapeuti ...
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Myosins and the dynamics of intracellular membranes (MYODYN)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

Myosins are fascinating proteins with unique biochemical and physical properties. The multiple roles that they play in the dynamics of intracellular membranes are only beginning to emerge. Recent findings from the research team have highlighted unexpected roles in membrane deformation and in membrane fission played by two myosins (myosin 1b and myosin II) functioning at the interface between the G ...
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 1

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Long Intervening Noncoding RNAs (lincRNAs): Developmental Functions and Molecular Mechanisms of Action (FLAME)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

Genome-wide studies have revealed that the majority of vertebrate genomes are transcribed and generate large numbers of long intervening noncoding RNAs (lincRNAs). While there is growing evidence that these molecules have functional importance for diverse cellular processes, such as dosage compensation, transcriptional regulation, and reprogramming, the role of lincRNAs in normal development remai ...
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 1

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Towards outstanding research and training in tumour biology at IMM (ReTuBi)

Start date: Jan 1, 2016, End date: Dec 31, 2018,

Cancer is a major societal health issue in Europe. In 2012, cancer accounted for around 1.3 million deaths and an estimated economic impact of around € 126 billion in the European Union (EU).The Instituto de Medicina Molecular (IMM) aims to fight this destructive disease by reinforcing its capacity for outstanding pre-clinical and translation research, and by creating a dynamic cluster of excellen ...
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Improving Design, Evaluation and Analysis of early drug development Studies (IDEAS)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

Drug development is a long and costly process which suffers from the major shortcoming that frequently failure is often only determined during the final stage. Recently, it has been recognised that more care needs to be taken during the early stages of development to avoid going into lengthy and costly confirmatory studies with ineffective or harmful treatments. To achieve this goal it is essentia ...
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 8

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Biochemical and mechanochemical mechanisms in polarized cells (BIOPOL)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

BIOPOL is an interdisciplinary European training network at the interface of cell biology, physics and engineering. BIOPOL aims specifically at the understanding of fundamental mechanochemical principles guiding cellular behaviour and function and their relevance to human disease. A new supra-disciplinary research field is emerging bringing together the fields of molecular cell biology, physics an ...
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 10

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Waves and Wave-Based Imaging in Virtual and Experimental Environments (WAVES)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

Demand for highly trained scientists with a deep understanding of wave propagation in complex media, and capable of exploiting this knowledge to develop imaging tools for seismology and acoustics, is very high in the Earth and environmental sciences. Wave-based imaging serves to map spatial and temporal variations in the structure of the Earth's interior, of the oceans and atmosphere; it is used t ...
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PERSONALIZED ENGINE FOR CANCER INTEGRATIVE STUDY AND EVALUATION (PrECISE)

Start date: Jan 1, 2016, End date: Dec 31, 2018,

Despite of their great promise, high-throughput technologies in cancer research have often failed to translate to major therapeutic advances in the clinic. One challenge has been tumour heterogeneity, where multiple competing subclones coexist within a single tumour. Genomic heterogeneity renders it difficult to identify all driving molecular alterations, and thus results in therapies that only ta ...
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Enabling a Mobility Back-End as a Robust Service (EMBERS)

Start date: Dec 1, 2015, End date: Nov 30, 2018,

EMBERS will bring to market a back-end for smart city mobility that is developed by a European small enterprise based upon its smart parking and smart traffic management products that two municipalities in Portugal currently deploy. The Mobility Back-end as a Service (MBaaS) replaces such all-in-one systems, in which a municipality purchases the full set of components from a single vendor. Instead ...
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 6

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Global BioImaging Project - International imaging infrastructure services for the life science community (Global BioImaging)

Start date: Dec 1, 2015, End date: Nov 30, 2018,

"The EC H2020 funded "Global BioImaging Project" enables Euro-BioImaging, the research infrastructure for access to biological and medical imaging technologies on the ESFRI roadmap, to work together with its international counterparts - the Australian Microscopy and Microanalysis Research Facility (AMMRF), the National Imaging Facility (Australia) and India-BioImaging - on concrete and sustainable ...
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 8

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Dynamics-aerosol-chemistry-cloud interactions in West Africa (DACCIWA)

Start date: Dec 1, 2013, End date: Nov 30, 2018,

"Massive economic and population growth and urbanisation are expected to lead to a tripling of anthropogenic emissions in southern West Africa (SWA) between 2000 and 2030, the impacts of which on human health, ecosystems, food security and the regional climate are largely unknown. An assessment of these impacts is complicated by (a) a superposition with effects of global climate change, (b) the st ...
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I-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly (I-MOVE-plus)

Start date: May 1, 2015, End date: Oct 31, 2018,

The I-MOVE+ Consortium includes European Union (EU) Public Health Institutes, SME and Universities. It aims at measuring and comparing the effectiveness (VE) and impact (VI) of influenza and Pneumococcal vaccines and vaccination strategies a in the elderly population in Europe. The goal is to develop a sustainable platform of primary care practices, hospitals and laboratory networks that share val ...
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FIRE+ online interoperability and performance test tools to support emerging technologies from research to standardization and market launchThe standards and innovations accelerating tool (F-Interop)

Start date: Nov 1, 2015, End date: Oct 31, 2018,

F-Interop will develop and provide remotely accessible tools to support and accelerate standardisation processes and products developments, by offsetting several cost and time barriers. It will research and develop a new FIRE experimental platform to support the development of new technologies and standards, from their genesis to the market for: online interoperability tests and validation tools, ...
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 12

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Health and Environment-wide Associations based on Large population Surveys (HEALS)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

Assessing individual exposure to environmental stressors and predicting health outcomes implies that both environmental exposures and epi/genetic variations are reliably measured simultaneously. HEALS (Health and Environment-wide Associations based on Large population Surveys) brings together in an innovative approach a comprehensive array of novel technologies, data analysis and modeling tools th ...
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EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma (EEC)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES o ...
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