Search for European Projects

27 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Modeling Disease through Cell Reprogramming: a Translational Approach to the Pathogenesis of Syndromes Caused by Symmetrical Gene Dosage Imbalances (DISEASEAVATARS)

Start date: Sep 1, 2014, End date: Aug 31, 2019,

The fundamental limitation in our ability to dissect human diseases is the scarce availability of human tissues at relevant disease stages, which is particularly salient for neural disorders. Somatic cell reprogramming is overcoming this limitation through the derivation of patient-specific induced pluripotent stem cells (iPSC) that can be differentiated into disease-relevant cell-types. Despite t ...
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 3

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Inside mechanisms sustaining cancer stem cells (InMec)

Start date: Jul 1, 2014, End date: Jun 30, 2019,

The “Cancer Stem Cell (CSC) Hypothesis” postulates that the capacity to maintain tumour growth is owned by rare cancer cells, the CSCs, endowed with self-renewal properties. This hypothesis implies that CSCs must be eliminated to achieve cancer cure. Nevertheless, direct proof is still lacking, and recent findings challenge our concepts of CSCs, showing the limits of the CSC-defining assay (transp ...
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 1

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Immune mechanisms that control the homeostasis of the gut and that are deregulated in intestinal pathologies cancer (HOMEOGUT)

Start date: Jul 1, 2014, End date: Jun 30, 2019,

This project stems from an ERC STG grant that I received in 2007 (DENDROworld) in which we analyzed several aspects of the homeostasis of the gut and how defects in controlling this process could result in different pathologies, including inflammatory bowel disease (IBD) and cancer. In the present project, we will continue working on the immune homeostasis of the gut and we will focus on fundament ...
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 3

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Universal Flu Vaccine (UNIVACFLU)

Start date: Nov 1, 2013, End date: Oct 31, 2017,

Currently licensed influenza vaccines promote an effective antibody response, but only against influenza virus strains that antigenically match the vaccine composition. Little protection is induced by these vaccines against antigenically drifted strains such as those emerging from an avian or swine reservoir. Hence there is a great need to develop broadly cross-reactive flu-vaccines.The aim is to ...
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 8

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A European Platform for Translational Cancer Research (EUROCANPLATFORM)

Start date: Jan 1, 2011, End date: Dec 31, 2016,

Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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 29

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Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation, in health and disease (4DCELLFATE)

Start date: Dec 1, 2011, End date: Nov 30, 2016,

Embryonic stem (ES) cells have the potential to differentiate into any type of cell as well as to renew indefinitely in culture. They hold great potential for the development of personalized medicines. However, the molecular mechanisms underpinning cell fate decisions by individual cells are poorly understood. There is compelling evidence that two large multi-protein machines, the Nucleosome Remod ...
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 13

 FINISHED 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Start date: Oct 1, 2011, End date: Sep 30, 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

 FINISHED 

"Connecting the activities of c-Myc in genome regulation, cellular growth control and oncogenesis" (MYCNEXT)

Start date: Jul 1, 2011, End date: Jun 30, 2016,

"The c-myc proto-oncogene is a general driving force in cancer. The cmyc product (Myc) is a transcription factor that binds thousands of genomic loci. However, the identity of the Myc-target genes that influence tumor development, as well as the mechanisms through which Myc acts on these genes, remain most elusive questions in the field. We will use next-generation DNA sequencing to create a multi ...
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 1

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Systems biology of liver cancer: an integrative genomic-epigenomic approach (MODHEP)

Start date: Jan 1, 2011, End date: Jun 30, 2016,

"Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplast ...
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 18

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The genomic blueprint of macrophages: dissecting players and mechanisms through an integrative approach (NORM)

Start date: Jun 1, 2011, End date: May 31, 2016,

"Macrophages are highly specialized cells widely distributed in tissues and active both as immune effectors and as housekeeping phagocytes responsible for maintenance of tissue integrity. Macrophages display a striking heterogeneity that reflects a complex interplay between different micro-environmental signals provided by various tissues (as well as by microbial and endogenous stress signals), an ...
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 1

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Role of human papillomavirus infection and other co-factors in the aetiology of head and neck cancer in India and Europe (HPV-AHEAD)

Start date: Sep 1, 2011, End date: Aug 31, 2015,

Human papillomavirus (HPV) is responsible for approximately 25% of head and neck cancer (HNC) worldwide and appears to be associated with a better response to treatment and improved prognosis. Evidence suggests that HPV-induced HNC has steadily increased in the USA and some European countries in the last decades. However, whether this is a worldwide phenomenon and specific risk factors are associa ...
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 11

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From data sharing and integration via VPH models to personalised medicine (p-medicine)

Start date: Feb 1, 2011, End date: Jul 31, 2015,

Medicine is undergoing a revolution that is transforming the nature of healthcare from reactive to preventive. The changes are catalyzed by a new systems approach to disease which focuses on integrated diagnosis, treatment and prevention of disease in individuals. This will replace our current mode of medicine over the coming years with a personalized predictive treatment . While the goal is clea ...
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 19

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AnThocyanin and polyphenol bioactives for Health Enhancement through Nutritional Advancement (ATHENA)

Start date: Jul 1, 2010, End date: Jun 30, 2015,

Anthocyanins are health promoting dietary polyphenols that protect against cardiovascular disease, caner and obesity in preclinical studies with animals. The ATHENA project will address how good dietary anthocyanins are in protecting against chronic disease, by addressing the following questions: • Benefits and risks: What is the dose response to anthocyanin phytonutrients? Are anthocyanins from d ...
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 14

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Systems Biology of Mitosis (MitoSys)

Start date: Jun 1, 2010, End date: May 31, 2015,

"MitoSys will generate a comprehensive mathematical understanding of mitotic division in human cells, a process of fundamental importance for human health. To create the critical mass and multidisciplinarity that is needed to achieve this ambitious goal, internationally leading mathematicians, biochemists/biophysicists and biologists working at twelve universities, research institutes, internation ...
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 14

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Molecular bases of kinetochore-microtubule attachment and their implications for cell cycle control (KINCON)

Start date: Mar 1, 2009, End date: Sep 30, 2014,

Equal partition of the genetic material to the daughter cells in mitosis requires the accurate anchorage of the mother cell s chromosomes to spindle microtubules. This process takes place at kinetochores, complex scaffolds containing ~100 different proteins. Conceptually, kinetochores can be viewed as performing four distinct but highly integrated functions: 1) they bind centromeric chromatin at a ...
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 3

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A Coordinated and Structured International Post-Doctoral Program to Foster Trans-national Mobility and Independent Career of Scientists in Biomedicine (SIPOD)

Start date: Mar 16, 2009, End date: Sep 15, 2014,

"This program encompasses the coordinated action of three major Biomedicine Research Centers and a Biotech shell in Lombardy, to launch a new Structured International Post-Doctoral program (SIPOD). These research centers operate in conjunction with the Scuola Europea di Medicina Molecolare (SEMM) whose aim is to promote the training and research of young scientists within emerging sectors of biome ...
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 4

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Euro-BioImaging - Research infrastructure for imaging technologies in biological and biomedical sciences (Euro-BioImaging)

Start date: Dec 1, 2010, End date: May 31, 2014,

Euro-BioImaging brings together imaging technologies stretching from basic biological imaging with advanced light microscopy, in vivo molecular imaging of single cells to animal models up to the clinical and epidemiological level of medical imaging of humans and populations. Euro-BioImaging, in close consultation with its stakeholders, will address the imaging requirements of both biological and m ...
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 44

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Mucosal dendritic cells in intestinal homeostasis and bacteria-related diseases (DENDROWORLD)

Start date: Jul 1, 2008, End date: Jun 30, 2013,

The bacterial microflora has always been regarded as beneficial for the host but recent studies have shown that this symbiosis has risks as well as benefits. Although active mechanisms allow tolerating the commensal flora, the physiological stress that is associated with the symbionts’ metabolism can exhaust the intestinal barrier resulting in serious effects on the health of the host. Protracted ...
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 1

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Health-promoting cross-talk between intestinal microbiota and Humans (CROSS-TALK)

Start date: Oct 1, 2008, End date: Sep 30, 2012,

The multi-partner initial training network entitled “Health-Promoting Cross-talk between Intestinal Microbiota and Humans (CROSS-TALK)” aims at: • Preparing qualified young professionals/researchers and future scientific leaders in the field of an emerging supra-discipline, the human microbiome metagenomics (which calls for new researcher curricula and fosters a dynamic scientific community) throu ...
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 10

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European Consortium for Systematic Stem Cell Biology (EUROSYSTEM)

Start date: Mar 1, 2008, End date: Aug 31, 2012,

EuroSyStem brings together elite European research teams to create a unique and world-leading programme in fundamental stem cell biology. By interconnecting complementary biological and computational expertise we will drive the generation of new knowledge on the characteristics of normal and abnormal stem cells. We will pave the way for application of systems methodology by measuring and modelling ...
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 25

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Metagenomics of the Human Intestinal Tract (MetaHIT)

Start date: Jan 1, 2008, End date: Jun 30, 2012,

A detailed understanding of human biology will require not only knowledge of the human genome but also of the human metagenome, defined here as the ensemble of the genomes of human-associated microorganisms. Our proposal focuses on the microorganisms of the gut, which are particularly abundant and complex and have an important role for human health and well-being. We shall implement and integrate ...
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 16

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Genomic determinants of inflammation: from physical measurements to system perturbation and mathematical modeling (Model-In)

Start date: Dec 1, 2008, End date: May 31, 2012,

Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to several diseases with a huge social impact, ranging from autoimmune diseases to septic shock and cancer. While the requirement ...
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 11

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Establishing an efficient network for cancer communication in Europe (Eurocancercoms)

Start date: May 1, 2009, End date: Sep 30, 2011,

The lack of efficient communication among cancer health professionals, patients and policy makers remains a significant barrier to collaboration in the EU. Information overload and a very fractionated, exhaustive array of resources, networks and knowledge providers are seriously hindering the translation and implementation of research in Europe. With the constant explosion of data we can expect to ...
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 18

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Mucosal protease and their inhibitors in inflammatory bowel disease: From etiopathogenetic insight to innovative therapy (IBDase)

Start date: Mar 1, 2008, End date: May 31, 2011,

IBDase addresses the etiology and pathogenesis of inflammatory bowel disease (IBD) with a multidisciplinary plan for innovative diagnosis and therapy focused on mucosal proteases and their inhibitors (P/PIs). The incidence of IBD, a multifactorial disease influenced by environmental factors in a background of complex genetic susceptibility, is rising, particularly among European children. Current ...
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 10

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Structural and Functional Characterization of the RZZ Complex (RZZ)

Start date: Apr 1, 2009, End date: Mar 31, 2011,

"This application is concerned with the structural and functional characterization of the RZZ protein complex, a critical constituent of metazoan kinetochores. The RZZ, a 400-kDa trimer, is named after the initials of its components, Rod, Zwilch and Zw10. The RZZ is implicated in the execution of mitosis, the process of equal partitioning of the genetic material. In mitosis, the sister chromatids ...
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 1

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Early and late health risks to normal/healthy tissues from the use of existing and emerging techniques for radiation therapy (ALLEGRO)

Start date: Feb 1, 2009, End date: Mar 31, 2011,

Curative cancer treatment with radiation seeks to optimise the magnitude of the radiation dose to the treatment volume while restricting the dose to normal healthy tissue. With an increasing population of surviving cancer patients treated with radiation therapy, the harmful effects of the radiation to normal tissue are becoming more evident. The ALLEGRO project will address the many aspects of n ...
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 13

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Genomic Instability in Cancer and Precancer (GENICA)

Start date: Jan 1, 2008, End date: Dec 31, 2010,

"Genomic instability is a characteristic of practically all human cancers. Recent results generated by members of this Consortium suggest that signs of genomic instability are evident from the very beginning of human cancer development, even in precancerous lesions. In these early lesions, the genomic instability affects primarily specific genomic loci, called common fragile sites. Because common ...
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 11