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Global regulation of lipid biosynthesis in Gram-positive bacteria: structural and biochemical characterization of FapR (FAPR)
Start date: Jul 1, 2008, End date: Mar 31, 2009,
FapR is a transcription factor that negatively controls the expression of several genes of the fatty acid and phospholipid biosynthesis in Bacillus subtilis. It is the first global regulator of lipid synthesis discovered in bacteria and is largely conserved in Gram positive organisms. A key intermediate in fatty acid biosynthesis, malonyl-CoA, acts as a negative effector of the transcriptional rep ...
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