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14 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Modulation of mitochondrial complex I as a strategy to increase lifespan and prevent age-related diseases (ComplexI&Aging)

Start date: Feb 1, 2011, End date: Sep 30, 2016,

Nowadays, ageing is one of the main problems in Western society. The increase in the percentage of elderly people serves to strain the Social Security to the point of bankruptcy. The only way to alleviate the suffering caused by age-related degenerative disease is to fully understand the underlying forces which drive ageing and design strategies to delay it. Mitochondria are considered as central ...
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 2

 FINISHED 

Molecular by-pass therapy for mitochondrial dysfunction (MITO BY-PASS)

Start date: Apr 1, 2009, End date: Mar 31, 2015,

Many eukaryotes, but not the higher metazoans such as vertebrates or arthropods, possess intrinsic by-pass systems that provide alternative routes for electron flow from NADH to oxygen. Whereas the standard mitochondrial OXPHOS system couples electron transport to proton pumping across the inner mitochondrial membrane, creating the proton gradient which is used to drive ATP synthesis and other ene ...
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 2

 FINISHED 

Pathogenesis of Type 1 Diabetes - Testing the Hygiene Hypothesis (DIABIMMUNE)

Start date: Mar 1, 2008, End date: Feb 28, 2014,

"Preliminary data indicate that there is a strong association between the incidence of immune-mediated diseases and improving standard of living and hygiene. One of the steepest gradient in standard of living worldwide is present at the border between Russian Karelia and Finland with a sevenfold difference in the gross national product, while Estonia represents a country in rapid transition. These ...
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 12

 FINISHED 

Parkinson disease susceptibility gene mutations in Drosophila melanogaster and the therapeutic potential of transgenes alternative oxidase and alternative NADH dehydrogenase (DroMit)

Start date: Aug 1, 2011, End date: Jan 31, 2014,

Mutations in human genes parkin and DJ-1 cause susceptibility to Parkinson's disease (PD). Both genes have functions linking them to mitochondria and oxidative stress. Parkin protein is a ubiqutin E3 ligase which targets damaged proteins for proteasomal degradation and it has also been shown to localize to dysfunctional mitochondria. Protein DJ-1 has functions as a ROS scavenger and a gene express ...
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 1

 FINISHED 

European Study to Establish Biomarkers of Human Ageing (MARK-AGE)

Start date: Apr 1, 2008, End date: Sep 30, 2013,

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variab ...
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 28

 FINISHED 

Prostate Research Organizations-Network of Early Stage Training (PRO-NEST)

Start date: Oct 1, 2009, End date: Sep 30, 2013,

"New and recent developments have revolutionized the prostate cancer research and clinical arenas, requiring the next generation scientists to have comprehensive knowledge and expertise in basic, clinical and applied research. PRO-NEST offers young researchers a European integrated, multi-disciplinary training programme to become an independent and all-round scientist and team leader in (prostate) ...
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 18

 FINISHED 

Media Accountability and Transparency in Europe (MediaAcT)

Start date: Feb 1, 2010, End date: Jul 31, 2013,

In this proposal, we suggest a comparative European research project on media accountability systems in EU member states as indicators for media pluralism in Europe. The project will analyze the development and impact of established media accountability systems (i.e. press councils, ethics codes) as well as new media accountability systems emerging in the Internet (i.e. media criticism in blogs). ...
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 14

 FINISHED 

PROPROTEIN CONVERTASE FURIN AS A REGULATOR OF IMMUNE RESPONSES (Furin in Immunity)

Start date: Jun 1, 2009, End date: May 31, 2013,

Backgound: Interleukin (IL)-12 induced T helper (Th) 1 polarization is critical for adequate cell-medated immune responses against intracellular pathogens such as M. tuberculosis. To gain insights into Th1 type immunity I performed a genome wide analysis for IL-12 target genes. The results unequivocally identified proprotein convertases (PC) furin as a novel IL-12/Stat4 target gene. Furin has been ...
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 1

 FINISHED 

health-economic modelling of PREvention strategies for Hpv-related Diseases in European CounTries (PREHDICT)

Start date: May 1, 2010, End date: Apr 30, 2013,

"The goals of the PREHDICT study are to determine prerequisites and strategies for vaccination in European countries and to predict the impact of vaccination on screening programmes. To achieve these goals, a multiple HPV type transmission model will be built to describe the type-specific incidence and clearance of HPV infections. This model will be linked to an individual-based simulation model u ...
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 14

 FINISHED 

Prostate cancer: profiling and evaluation of ncRNA (ProspeR)

Start date: Feb 1, 2008, End date: Jul 31, 2012,

Annually, over 200 000 new prostate cancer cases are diagnosed in Europe. This number is expected to further increase due to widespread use of prostate specific antigen (PSA) tests on asymptomatic men and an aging population. This leads to high rate of over-detection, where most cases will never experience cancer symptoms during their lifetime. Hence, our current lack of means to predict prostate ...
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 8

 FINISHED 

FUTURAGE: A Roadmap for Ageing Research (FUTURAGE)

Start date: Sep 1, 2009, End date: Dec 31, 2011,

"FUTURAGE aims to produce the definitive road map that will guide European research on ageing and health for the next 10-15 years. It represents plans for the most extensive consultation ever conducted in this field and for the mobilisation of not only the leading scientists but also the stakeholders that will determine the fate of the road map. FUTURAGE combines all of the major coordination acti ...
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 24

 FINISHED 

"Transnationalisation, Migration and Transformation: Multi-Level Analysis of Migrant Transnationalism (TRANS-NET)" (TRANS-NET)

Start date: Mar 1, 2008, End date: Feb 28, 2011,

"The objective of this project is to clarify and compare the complex process of transnationalism. During the past few years, transnationalism has attained ever greater importance and topicality due to the increase in transnational mobility of people. In order to attain a comprehensive and valid insight into the topic in question we adopt a multilevel approach. The research conducted in Estonia, Fi ...
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 8

 FINISHED 

Intangible Assets and Regional Economic Growth (IAREG)

Start date: Feb 1, 2008, End date: Jul 31, 2010,

"The objective of IAREG is to analyse the role played by intangible assets (IA) in the generation of innovation, competitiveness and consequently economic growth and increases in productivity at regional level with a special emphasis on the geographical space in which such processes occur. The specific objectives of the project will be: To develop new indicators for improving the measuring of som ...
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 13

 FINISHED 

PREPARATORY PHASE PROJECT FOR A MAJOR UPGRADE OF THE COUNCIL OF EUROPEAN SOCIAL SCIENCE DATA ARCHIVES (CESSDA) RESEARCH INFRASTRUCTURE (CESSDA-PPP)

Start date: Jan 1, 2008, End date: Jun 30, 2010,

"This proposal for a major upgrade to the CESSDA Research Infrastructure is a response to the general principles and vision set out in the 2004 Blueprint for the European Research Obsrvatory for the Humanities and Social Science and will meet the goals set out in that report to ‘strengthen interdisciplinary and cross-border collaboration and comparative research on a European dimension… enhance th ...
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 17