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Over 40 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Sweet Theranostics in Bitter Infections - Seek and Destroy (SWEETBULLETS)

Start date: Feb 1, 2017, End date: Jan 31, 2022,

Bacterial infections are now a global threat demanding novel treatments due to the appearance of resistances against antibiotics at a high pace. The ESKAPE pathogens are those with highest importance in the EU and chronic infections due to biofilm formation are a particular task. Noninvasive pathogen-specific imaging of the infected tissue is not clinically available. Its successful implementation ...
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 1

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New siRNA Nanotherapy for Inflammatory Bowel Diseases, targeting Janus kinase 3 (NEW DEAL)

Start date: Feb 1, 2017, End date: Jan 31, 2021,

Inflammatory bowel diseases (IBD) are the second most common immune-mediated disorders in Europe, affecting more particularly young people. The current therapies, including antibodies, show three main drawbacks: efficacy, tolerability and convenience. NEW DEAL solution will offer radical therapeutic progress for all IBD patients, thanks to the improved efficacy and increased safety of the specific ...
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 11

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Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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 33

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Training network providing cutting-EDGE knowlEDGE on Herpes Virology and Immunology (EDGE)

Start date: May 1, 2016, End date: Apr 30, 2020,

Herpesviruses are widely spread, and cause life-long infections. Most individuals carry multiple herpesviruses, which can cause severe diseases, especially in children, immunocompromised individuals, and elderly. There are currently no safe vaccines against herpesvirus infections and current treatments are not satisfactory. With new insights into the molecular basis for diseases caused by immunode ...
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 9

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Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Start date: Jan 1, 2013, End date: Dec 31, 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

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European Network linking informatics and genomics of helper T cells (ENLIGHT-TEN)

Start date: Oct 1, 2015, End date: Sep 30, 2019,

ENLIGHT-TEN is a European Network Linking Informatics and Genomics of Helper T cells: our mission is to provide cross-disciplinary training in cellular immunology and big data analysis such that we train a new generation of researchers to fully exploit the power of emerging technological platforms. Our network of TEN beneficiaries combines T cell expertise with state-of-the-art technologies such a ...
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 11

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European Marine Biological Research Infrastructure Cluster to promote the Blue Bioeconomy (EMBRIC)

Start date: Jun 1, 2015, End date: May 31, 2019,

Marine (blue) biotechnology is the key to unlocking the huge economic potential of the unique biodiversity of marine organisms. This potential remains largely underexploited due to lack of connectivity between research services, practical and cultural difficulties in connecting science with industry, and high fragmentation of regional research, development and innovation (RDI) policies. To overcom ...
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 27

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Golden Mycological Triangle – joining forces to exploit mycological biodiversity for novel anti-infectives and other beneficial metabolites (GoMyTri)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

The proposed project aims at the intensification of cooperations between research infrastructure organisations in German, the Netherlands and Thailand that are recognised internationally as strongholds in mycological, biotechnological and microbiological research. The cooperation is intended to explore the mycological and microbiological biodiversity of Europe and Southeast Asia, in particular wit ...
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 2

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Design and development of advanced NAnomedicines to overcome Biological BArriers and to treat severe diseases (NABBA)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

Many therapeutic targets are shielded behind biological barriers, limiting the possibility to reach them with conventional drugs or diagnostic probes. Biological barriers are even more problematic for most biological pharmaceutics, such as recombinant proteins, antibodies and gene therapeutics. The most promising solution to this challenge is the use of nano-vehicles for specific targeting and del ...
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 6

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Identifying the immune and microbial network controlling the IL-22 – IL-22bp axis to open the doors for targeted therapies (IL-22 and IL-22BP)

Start date: Jan 1, 2014, End date: Dec 31, 2018,

Chronic mucosal inflammation and tissue damage predisposes patients to the development of colorectal cancer. One hypothesis is that the same factors important for wound healing, if left unchecked, also promote tumorigenesis. Tight control by a sensor of tissue damage should induce these factors to promote tissue repair, while limiting their activity to prevent development of cancer.IL-22, a protot ...
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 2

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Rewiring the Streptomyces cell factory for cost-effective production of biomolecules (STREPSYNTH)

Start date: Dec 1, 2013, End date: Nov 30, 2018,

STREPSYNTH aims to set-up a Streptomyces-based new industrial production platform (SNIP) for high value added biomolecules. Streptomyces lividans was chosen as a bacterial host cell because it has been already shown to be highly efficient for the extracellular production of a number of heterologous molecules that vary chemically, has a robust tradition of industrial fermentation and is fully acces ...
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 17

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A “Universal” Influenza Vaccine through Synthetic, Dendritic Cell-Targeted, Self-Replicating RNA Vaccines (UniVax)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

Although vaccination is the cornerstone of prophylaxis, current vaccines provide only moderate protection. Most employ inactivated or protein-based, including multimeric antigen, vaccines requiring annual updating. Their limited antigen loads provide limited capacity for inducing robust immune defences, without assurance that both humoral and cell mediated (CMI) responses, as well as durable immun ...
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 11

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Rapid Antimicrobial susceptibility testing and phylogenetic Identification (RAPID)

Start date: Oct 1, 2016, End date: Mar 31, 2018,

Emerging resistance towards antimicrobials marks this decade and the lack of therapy options especially against gram-negative pathogens underscores the need for optimization of current diagnostics, therapies and prevention of the spread of these organisms. In this proposal the PIs medical microbiology background and previous ERC-funded work on molecular resistance markers is exploited towards the ...
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 1

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Protecting the health of Europeans by improving methods for the detection of pathogens in drinking water and water used in food preparation (Aquavalens)

Start date: Feb 1, 2013, End date: Jan 31, 2018,

The AQUAVALENS consortium has brought together SMEs, Industries, Universities and Research Institutes with the mission of protecting the health of European Citizens from contaminated drinking water and water used in food processing. We will achieve this by developing sustainable technologies to enable water system managers whether in large or small water systems or within food growers or manufactu ...
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 43

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Improving Outcome of Necrotizing Fasciitis: Elucidation of Complex Host and Pathogen Signatures that Dictate Severity of Tissue Infection (INFECT)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

The overall goal with INFECT is to advance our understanding of the pathophysiological mechanisms, prognosis, and diagnosis of the multifactorial highly lethal NSTIs. The fulminant course of NSTIs (in the order of hours) demands immediate diagnosis and adequate interventions in order to salvage lives and limbs. However, diagnosis and management are difficult due to heterogeneity in clinical presen ...
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 16

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Parasite glycobiology and anti-parasitic strategies (GLYCOPAR)

Start date: Dec 1, 2013, End date: Nov 30, 2017,

"Protozoan parasites and helminths are the cause of some of the most devastating diseases worldwide and a major effort is needed to be able to control or eliminate these diseases. Glycoconjugates are abundant and ubiquitous on the surface of many parasites and they are frequently involved in their survival strategies by forming a protective barrier against host defences. A common feature of the pa ...
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 13

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Competency-based COurse on Translational Research and MEdiciNes Development for PhDs and Post-docs

Start date: Nov 1, 2015, End date: Oct 31, 2017,

Background: Translational research and medicines development refers to the translation of basic scientific discoveries into clinical applications such as new therapeutic, diagnostic or preventive products. Translational research and medicines development thus lays at the foundation of any improvement of human health and quality of life, and is a motor for growth and innovation. In order to be succ ...
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 5

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Collaboration on the Optimisation of Macromolecular Pharmaceutical Access to Cellular Targets (COMPACT)

Start date: Nov 1, 2012, End date: Oct 31, 2017,

Most biopharmaceuticals (BP) currently on the market are recombinant proteins which are parenterally administered. These would benefit from more patient-friendly routes of administration. Moreover, new classes of BP (e.g. siRNA, miRNA, DARPins) with specificity for intracellular targets hold promise but await the advent of efficient delivery systems before their potential can be realised into ther ...
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 22

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Interplay of inflammasomes, commensals and pathogens at mucosal interfaces (InflaComm)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

Inflammasomes are multi-protein complexes that control the activity of the cysteine protease caspase-1. Inflammasomes are assembled around one of several different sensor proteins, which enable inflammasome activation after sensing of diverse microbial and endogenous damage-associated molecules. Recently, I discovered a novel role for the NLRP6 inflammasome in regulation of the intestinal microbio ...
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 1

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Innovative, mechanistic-based strategies for delivery of therapeutic macromolecules across cellular and biological barriers (PathChooser)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

Nanomedicine offers capability to significantly change the course of treatment for life-threatening diseases. Many of the most significant current therapeutic targets, to be viable in practice, require the efficient crossing of at least one biological barrier. However, the efficient and controlled crossing of the undamaged barrier is difficult. The range of small molecules that can successfully do ...
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 9

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Immune modulation by lymph node stromal cell-derived extracellular vesicles (IMSTREV)

Start date: Jul 1, 2015, End date: Jun 30, 2017,

Regulatory T cells (Tregs) are essential for maintenance of immune homeostasis and peripheral tolerance. The unique challenge to discriminate between pathogens and commensals requires the dynamic adaptation of Tregs to the microenvironment, particularly in the intestinal mucosa. Accordingly, although Tregs are primarily generated in the thymus, they can be also generated in the periphery, and gut- ...
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 1

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Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation (INFRAFRONTIER-I3)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:• Develop a series of mutant alleles for every gene in the mouse genome• Determine the phenotypic consequences of each mutation• Identify mouse models for the complete dise ...
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 24

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Exploitation of actinomycetes genomics using synthetic and system biology approaches (EXPLOGEN)

Start date: Jan 1, 2012, End date: Dec 31, 2016,

"Actinomycetes produce a wealth of important natural products, which play a pivotal role in modern drug-based therapy of various diseases. Recent whole-genome sequencing projects have revealed that the number of biosynthetic gene clusters significantly outnumbers the natural products produced by actinomycetes under laboratory conditions. Only a minority of biosynthetic gene clusters are expressed ...
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 1

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Molecular mechanisms of persistent antigenic stimulation in cytomegalovirus infection (CMVAgSTIMULUS)

Start date: Apr 1, 2011, End date: Sep 30, 2016,

Cytomegalovirus (CMV) is a ubiquitous herpesvirus, latently persisting in the majority of the adult population worldwide. In these hosts, CMV-specific memory cells dominate the immune memory compartment. It follows that CMV-specific T-cells dominate the memory compartment of the majority of the human population worldwide.I propose to define within this project the molecular mechanisms driving the ...
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 1

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European Medicines Research Training Network (EMTRAIN)

Start date: Oct 1, 2009, End date: Sep 30, 2016,

EMTRAIN is an essential element for the success of the IMI Education & Training (E&T) Call Topics in Europe (current and future). It will establish a pan-European platform of excellence for education and training covering the whole life-cycle of medicines from basic research through clinical development to pharmaco-vigilance. It will underpin the successful delivery of the current and future IMI-f ...
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 32

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New Technologies and Production Tools for Complex Protein Biologics (ComplexINC)

Start date: Nov 1, 2011, End date: Oct 31, 2015,

ComplexINC conceptualizes and systematically generates advanced tool-kits to enable high-throughput assembly of complex biologics and metabolic pathways in eukaryotic expression systems, for micro- to large scale production of high-quality protein specimens for drug discovery and as bio-therapeutics. Essential parts of these tool-kits will be innovative next-generation HT DNA assembly pipelines fo ...
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 8

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Towards an individualised therapy and prevention of multi-drug resistant disease (RESISTOME)

Start date: Nov 1, 2010, End date: Oct 31, 2015,

In this proposal the PIs medical microbiology background and previous internationally acknowledged work on molecular persistence mechanism of the gram-negative bacterial pathogen Pseudomonas aeruginosa is exploited towards a novel approach that could change the current paradigm of antibiotic resistance testing. Emerging resistance towards antimicrobials marks this decade and the lack of new therap ...
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 1

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Influence of Streptococcal virulence factors on host autophagy regulation (GASAUTOPHAGY)

Start date: May 1, 2013, End date: Apr 30, 2015,

"Group AStreptococcus (GAS) is a predominant Gram-positive bacterium causing a substantial burden of diseases in humans. Autophagy is a starvation-induced response that provides nutrients by degrading long-living proteins and recycling intracellular organelles. In 2004, autophagy was identified as a new immune mechanism for killing and clearing invading GAS in epithelial cells. It is regulated by ...
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 1

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European Infrastructure of Open Screening Platforms for Chemical Biology (EU-OPENSCREEN)

Start date: Nov 1, 2010, End date: Apr 30, 2015,

The EU-OPENSCREEN Preparatory Phase forms the basis for the construction and operation of a pan-European infrastructure of open screening platforms for Chemical Biology. EU-OPENSCREEN will bring together leading laboratories from 14 European countries covering all aspects of Chemical Biology from high-throughput screening with a dedicated compound library to assay development, chemical synthesis f ...
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 24

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Genomic predictors and oncogenic drivers in hepatocellular carcinoma (HEPTROMIC)

Start date: Nov 1, 2010, End date: Apr 30, 2014,

"Hepatocellular carcinoma (HCC) accounts for more than 90% of liver cancers, and is a major health problem. Its incidence is growing and with more than 700,000 annual cases worldwide -50,000 in Europe-, it is the 3rd cause of cancer-related mortality. Most patients are diagnosed at advanced stages with dismal survival rates lower than 1 year, even after sorafenib, the sole systemic therapy availab ...
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 10

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Molecular Approaches and MetaGenomic Investigations for optimizing Clean-up of PAH contaminated sites (MAGICPAH)

Start date: Apr 1, 2010, End date: Mar 31, 2014,

"MAGICPAH aims to explore, understand and exploit the catalytic activities of microbial communities involved in the degradation of persistent PAHs. It will integrate (meta-) genomic studies with in-situ activity assessment based on stable isotope probing particularly in complex matrices of different terrestrial and marine environments. PAH degradation under various conditions of bioavailability wi ...
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 15

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Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases (OptiStem)

Start date: Jan 1, 2009, End date: Dec 31, 2013,

This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and ...
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 20

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The Microme Project: A Knowledge-Based Bioinformatics Framework for Microbial Pathway Genomics (Microme)

Start date: Dec 1, 2009, End date: Nov 30, 2013,

The exponential increase in microbial genome and metagenome sequencing throughput has widened the gap between sequence and functional understanding. A clear picture of metabolic processes across the spectrum of bacterial species is essential to enable the exploitation of microbial genomics for the purposes of environmental biotechnology. The Microme project endeavors to extend the scope of microbi ...
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 16

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European Network of Vaccine Development and Research (TRANSVAC)

Start date: Oct 1, 2009, End date: Sep 30, 2013,

"The TRANSVAC infrastructure will accelerate the pharmaceutical and clinical development of promising vaccine candidates by bringing the gap between academic research and clinical trials through carefully managing the advancement of promising vaccine candidates from preclinical animal models to early proof-of-principle studies in humans. Although expertise already exists within Europe spanning dif ...
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 18

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Identification and validation of novel drug targets in Gram-negative bacteria by global search: a trans-system approach (AntiPathoGN)

Start date: Feb 1, 2009, End date: Jul 31, 2013,

Multi-drug-resistant bacterial infections are increasing at an alarming pace in both developing and developed countries and in both community and nosocomial settings. The few antimicrobial agents that have been launched during the last decade (e.g. linezolid, daptomycin) have a good activity against Gram-positive bacteria. However, multi-drug-resistant bacteria are often found among the Gram-negat ...
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 11

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Novel strategies for the prevention and control of persistent infections (NOPERSIST)

Start date: Jan 1, 2010, End date: Dec 31, 2012,

"Persistent infections such as HIV, tuberculosis´(TB) in humans and para-tuberculosis (ParaTB)-, mycoplasma- and Haemophilus-infections in farm animals are global health problems of immense social and economic importance . HIV-1 affects about 40 million people and M. tuberculosis infection is even higher world-wide. Co-infection with M. tuberculosis is estimated in about one-third of HIV-1 infecte ...
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 12

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Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes (INFRAFRONTIER)

Start date: Mar 1, 2008, End date: Dec 31, 2012,

Medically related Life Sciences use the mouse as a model system to understand the molecular basis of health and disease in humans (>95% similarity of genes in humans and mice). An essential task for Biomedical Sciences in the 21st century will be the functional analysis of mouse models for every gene in the mammalian genome. The major bottlenecks identified by the user community will be proper ...
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 29

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Bacterial Abiotic Cellular Stress and Survival Improvement Network (BACSIN)

Start date: Jun 1, 2008, End date: May 31, 2012,

BACSIN is a 16-member consortium with the main focus to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of environmental pollution. Current application of bacteria in the environment is hindered by the lack of knowledge on the effects of stresses on cellular activity, most importantly abiotic stresses prevailing on site (e.g., desiccation or n ...
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 16

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Combating Antibiotics Resistant Pneumococci by Novel Strategies Based on in vivo and in vitro Host – Pathogen Interactions (CAREPNEUMO)

Start date: Mar 1, 2009, End date: Feb 29, 2012,

"The diseases caused by Streptococcus pneumoniae are a major public health problem all over the world. Children, elderly people and immuno-compromised individuals are the high-risk targets for pneumococcal diseases. In spite of the availability of a large number of antibiotics the mortality and morbidity due to S. pneumoniae infections remain very high. There are two reasons for this: Firstly, the ...
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 13

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Development of a two-approach plate system for the fast and simultaneous detection of MDR and XDR M. tuberculosis (FAST-XDR-DETECT)

Start date: Feb 1, 2008, End date: Jan 31, 2012,

Tuberculosis (TB) continues being a leading cause of death due to a single infectious disease agent. The HIV/AIDS pandemic and the emergence of drug resistance are compounding factors that hinder the control of the disease. Associated with this problem is the emergence of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, defined as strains resistant to at least isoniazid and rifampi ...
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 8