Search for European Projects

10 European Projects Found

Searched on 125080 European Projects

 FINISHED 

BeTheCuRE (BTCURE)

Start date: Apr 1, 2011, End date: Mar 31, 2017,

BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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 41

 FINISHED 

Scaffolds for alternative delivery (SADEL)

Start date: Jan 1, 2012, End date: Dec 31, 2016,

The SME-based SADEL consortium intends to develop the first generation of oral bio-therapeutics tackling disease targets in the digestive tract, by making optimal use of the Nanofitin (Nf) protein scaffold. Nf based drugs will progress through routes not travelled by antibodies while interacting with targets not modulated by chemical compounds.Existing Nf hits against validated targets will progre ...
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 10

 FINISHED 

Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation (INFRAFRONTIER-I3)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:• Develop a series of mutant alleles for every gene in the mouse genome• Determine the phenotypic consequences of each mutation• Identify mouse models for the complete dise ...
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 24

 FINISHED 

Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices (Masterswitch)

Start date: Dec 1, 2008, End date: Nov 30, 2013,

Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The ...
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 20

 FINISHED 

Chromatin diseases: from basic mechanisms to therapy (DisChrom)

Start date: Nov 1, 2009, End date: Oct 31, 2013,

The scope of this ITN is to promote research and training in the field of chromatin diseases. Chromatin diseases (CD) are genetic pathologies resulting from mutations in structural components of chromatin or in enzymes that biochemically modify chromatin, altering chromatin status and thereby causing drastic effects on gene expression. CD frequency ranges from very rare to quite common pathologies ...
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 11

 FINISHED 

“The International Data Coordination Centre” (I-DCC)

Start date: Jan 1, 2009, End date: Sep 30, 2013,

"The I-DCC coordination and support project responds to the topic defined by HEALTH-2007-2.1.2-6 “International activities in large-scale data gathering and systems biology”. I-DCC integrates European skills, efforts, resources, and infrastructure in an international collaborative programme to establish a European Data Coordination Centre for mouse genetic resources. Large-scale mouse mutagenesis ...
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 10

 FINISHED 

Biology of Liver and Pancreatic Development and Disease (BOLD)

Start date: Sep 1, 2009, End date: Aug 31, 2013,

Aims: provide a cutting edge research training programme encompassing complementary approaches to the investigation of liver and pancreatic development and disease. Provide early stage researchers with a balanced mix of experience and skills in academic and industry based research. Give early stage researchers a set of transferrable skills which will improve their employment and career prospects. ...
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 12

 FINISHED 

Development of sensitive methodologies for exploitation of early epigenetic marker diagnosis in major types of cancer (EpiDiaCan)

Start date: Jan 1, 2010, End date: Dec 31, 2012,

Cancer is one of the major causes of mortality. Epithelial cells become malignant after accumulating genetic mutations followed by morphological changes in the epithelium. DNA Alterations include stable genetic changes in oncogenes, tumor suppressor genes and reversible epigenetic changes. Different forms of epigenetic mechanisms have been shown to modify the expression of key genes during tumour ...
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 7

 FINISHED 

Enhancing BSRC Al. Fleming research potential in genomics and proteomics applications (GENPRO)

Start date: Dec 1, 2009, End date: Nov 30, 2012,

"BSRC Al. Fleming is the most rapidly developing research center in Greece. It started its operation under an interim administrative board in 1998 and develops research programs at the cutting edge of modern biomedical sciences. The aim of this project is to reinforce and enhance the scientific research potential of the BSRC Al. Fleming in the areas of functional genomics and proteomics. This aim ...
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 1

 FINISHED 

Coordination of resources for conditional expression of mutated mouse alleles (CREATE)

Start date: Nov 1, 2008, End date: Oct 31, 2011,

"This proposal describes CREATE, an internationally based Coordination Action directly addressing a large scale data gathering activity for systematic conditional mouse mutagenesis. Advances in the sophisticated manipulation of the mouse genome has established the mouse as the premier organism for developing models of human disease. Internationally coordinated initiatives have established for the ...
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 8