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3 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Chromatin and MetabolismChromatin-metabolism interactions as targets for healthy living (ChroMe)

Start date: Mar 1, 2016, End date: Feb 29, 2020,

Metabolic disorders are at pandemic levels. Based on recent estimates, ~50% of Europeans are overweight, 20% are obese and 10% have type II diabetes. Obesity and insulin resistance impact European health to the tune of €110 billion per year. These disorders have genetic, nutritional and lifestyle causes. However, the molecular mechanisms that link nutrients and lifestyle to gene activity and chrom ...
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Cell of origin/Leukemia Initiating Cell in infant Pro-B MLL-AF4+ ALL (MODELING MLL-AF4 ALL)

Start date: May 1, 2014, End date: Apr 30, 2018,

"Infant pro-B acute lymphoblastic leukemia (ALL) carrying the fusion oncogene MLL-AF4 is associated with very brief latency and dismal prognosis. Recent studies have revealed an in utero origin of MLL-AF4 but the nature of the target cell for transformation in the embryo/fetus is unknown. Because of the mixed phenotype and the presence of MLL-AF4 in both lymphoid and myeloid lineages, hematopoieti ...
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 1

 FINISHED 

GENOMIC, CELLULAR AND DEVELOPMENTAL RECONSTRUCTION OFINFANT MLL-AF4+ ACUTE LYMPHOBLASTIC LEUKEMIA (INFANTLEUKEMIA)

End date: Jan 1, 2016,

Infant cancer is very distinct to adult cancer and it is progressively seen as a developmental disease. An intriguing infant cancer is the t(4;11) acute lymphoblastic leukemia (ALL) characterized by the hallmark rearrangement MLL-AF4 (MA4), and associated with dismal prognosis. The 100% concordance in twins and its prenatal onset suggest an extremely rapid disease progression. Many key issues rema ...
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 1