2 European Projects Found
Searched on 125080 European Projects
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Targeting the Notch Protease Interface (NOTCH PROTEOLYSIS)
Start date: Sep 1, 2008, End date: Feb 28, 2014,
NOTCH signaling is a highly conserved short-range signaling pathway involved in virtually every aspect of embryonic development and controls homeostatic self-renewal in many adult tissues. Germ line mutations in the NOTCH pathway cause several hereditary diseases, and somatic mutations are found in cancer. NOTCH pathway activity is governed by ligand induced proteolytic cleavage of the receptor in ...
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Role of skin dendritic cells in stimulating immune responses initiated in skin (SKIN IMMUNITY)
Start date: Jul 1, 2008, End date: Jun 30, 2010,
Dendritic cells in peripheral immune organs are quiescent sentinels that continuously survey their surroundings by fluid phase uptake and endocytosis. Dendritic cells become activated when pathogen-derived fragments are detected. Engulfed material is now processed into peptides and lipids for incorporation into peptide/MHC or lipid/CD1 complexes, for display to MHC- and CD1-restricted T cells resp ...
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