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Over 40 European Projects Found

Searched on 125080 European Projects

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4D analysis of heart development and regeneration using advanced light microscopy (4DHeart)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Cardiovascular (CV) disease is a main cause of death worldwide. During adulthood, ischemic heart disease leads to heart failure and perinatally, congenital heart defects are found in over 20% of deaths. Moreover, genetic or epigenetic factors altering development can have an impact much later in life. These facts underscore the need of a better understanding of the genetic and environmental factor ...
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 7

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YOUNGatHEART: CARDIAC REJUVENATION BY EPIGENETIC REMODELLING (YOUNGatHEART)

Start date: Nov 1, 2015, End date: Nov 1, 2020,

Aging poses the largest risk for cardiovascular disease (CVD) and is orchestrated, to some extent, by epigenetic changes. Despite the significant progress on many fronts in the cardiovascular field, non-inherited epigenetic regulation in cardiac aging and CVD remains unexplored. Dilated Cardiomyopathy (DCM) is a major contributor to healthcare costs and it is the leading indication for heart trans ...
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Molecular strategies to treat inherited arrhythmias (EU-rhythmy)

Start date: Nov 1, 2015, End date: Oct 31, 2020,

Sudden cardiac death (SCD) is a leading cause of death in western countries: coronary artery disease is the major cause of SCD in older subjects while inherited arrhythmogenic diseases are the leading cause of SCD in younger individuals. After 25 years dedicated to research of the molecular bases of heritable arrhythmias, the PI of this proposal now intends to pioneer gene therapy for prevention o ...
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 3

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Professional cross-priming for ovary and prostate cancer (PROCROP)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

Immune responses are initiated by antigen presentation mediated by dendritic cells (DC). There is a minority subset of DC highly specialised in starting up cytotoxic T lymphocytes able to kill tumor cells. PROCROP aims to develop in three pilot clinical trials a suitable individualized cancer vaccine technology for castration resistant prostate cancer and metastatic cancer of the ovary that would ...
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 8

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Secondary prEvention of CardiovascUlaR disease in the Elderly trial (SECURE)

Start date: May 1, 2015, End date: Apr 30, 2020,

While Cardiovascular diseases (CVD) are the main cause of death worldwide, they are responsible for half of all deaths in Europe. The overall ageing of the European population and improving survival of patients with coronary heart disease has created a large population of older adults eligible for secondary prevention. Despite the established efficacy of cardiovascular medications, suboptimal adhe ...
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 13

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Epistasis analysis of angiogenes with high cellular definition (AngioGenesHD)

Start date: Mar 1, 2015, End date: Feb 29, 2020,

Blood and lymphatic vessels have been the subject of intense investigation due to their important role in cancer development and in cardiovascular diseases. The significant advance in the methods used to modify and analyse gene function have allowed us to obtain a much better understanding of the molecular mechanisms involved in the regulation of the biology of blood vessels. However, there are tw ...
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Comprehensive Lifestyle Intervention Project (CLIP) (CLIP)

Start date: Jan 1, 2017, End date: Dec 31, 2019,

Cardiovascular disease (CVD) incidence continues to rise at an alarming rate largely as a consequence of behavioural risk factors. The only way to tackle this epidemic is to implement preventive strategies before the disease appears. Current evidence suggests that conventional approaches are inadequate for promoting healthier lifestyles, and therefore implementation of novel methods is desperately ...
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Novel insights into cardiac regeneration through studies in the zebrafish (zebraHeart)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

Myocardial infarction (MI) leads to cardiomyocyte death and accumulation of myofibroblasts (MFs) at the site of injury, which produce large amounts of extracellular matrix (ECM), generating a scar. Initially, cardiac fibrosis protects from ventricular wall rupture, but subsequent myocardial remodelling causes heart failure, representing a leading cause of death in Europe. While MFs play a central ...
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 2

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Biochemical and mechanochemical mechanisms in polarized cells (BIOPOL)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

BIOPOL is an interdisciplinary European training network at the interface of cell biology, physics and engineering. BIOPOL aims specifically at the understanding of fundamental mechanochemical principles guiding cellular behaviour and function and their relevance to human disease. A new supra-disciplinary research field is emerging bringing together the fields of molecular cell biology, physics an ...
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 10

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CNIC International Postdoctoral Programme (CNIC IPP)

Start date: Jun 3, 2013, End date: Jun 2, 2018,

"The proposed CNIC International Postdoctoral Programme (CNIC IPP) is aimed at supporting trans-national mobility of postdoctoral researchers and to broaden and deepen their individual competence, particularly in terms of acquisition of complementary skills needed to become an independent group leader in the future.The programme offers fellowships for researchers who hold a PhD Degree at the time ...
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Molecular mechanisms regulating cardiovascular remodeling by Adamts1 (MERC)

Start date: Jun 1, 2016, End date: May 31, 2018,

Professor Redondo’s group has recently identified Adamts1 as one of the major mediators in vascular wall remodeling. They showed that Adamts1+/-, Adamts1-/- and KD-Adamts1 mice present aortic dilation, aneurysms, medial degeneration and hypotension, leading to the hypothesis that Adamts1 deficiency results in a new familial form of thoracic aortic aneurysm (FTAAD) potentially relevant in human aor ...
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APERIM: Advanced bioinformatics platform for PERsonalised cancer IMmunotherapy (APERIM)

Start date: May 1, 2015, End date: Apr 30, 2018,

Cancer treatment platforms that involve the use of the adaptive immune system have demonstrated profound tumour regressions including complete cure. Importantly, technological advances in next-generation sequencing (NGS) allow for the first time the development of personalised cancer immunotherapies that target patient specific mutations. However, clinical application is currently hampered by spec ...
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 11

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microRNA replacement therapy for mature B cell neoplasias (HEAL-BY-MIRNA)

Start date: May 1, 2016, End date: Oct 31, 2017,

Mature B cell neoplasias include most of Non-Hodgkin Lymphomas (NHL), such as Diffuse Large B Cell Lymphomas and Burkitt Lymphoma and also B cell Chronic Lymphocytic Leukemia. It is estimated that about 60000-80000 new cases of mature B cell neoplasias are diagnosed every year in Europe. About 60% of NHL present with aggressive forms, and need immediate therapeutic action. The most common choice o ...
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Next generation training in cardiovascular research and innovation (CardioNext)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

CardioNext is an innovative training proposal organised by researchers at the Spanish National Centre for Cardiovascular Research (CNIC) to achieve three key aims. (i) Recruit talented and motivated graduate students to be trained as a new generation of translational researchers in cardiovascular disease. (ii) Create a well-developed and inter-connected network of academic scientific researchers a ...
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COMBINATIONAL USE OF INNATE IMMUNE RECEPTORS FOR CANCER IMMUNOTHERAPY (PRR IN IMMUNOTHERAPY)

Start date: Jun 1, 2013, End date: May 31, 2017,

Cancer is a major scientific and economical challenge that our society has to face and new therapeutic approaches should now be evaluated in order to decrease human and financial cost of this disease. After suffering from many drawbacks, cancer immunotherapy, which aims at mobilizing the immune system to fight cancer, has recently gained enthusiasm with the completion of several randomized phase I ...
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Mechanisms of MTOC guidance and Genetic Transfer at the Immune Synapse: novel modes of Immuno-modulation (GENTRIS)

Start date: Feb 1, 2012, End date: Jan 31, 2017,

"Cell-cell synapses are an exquisitely evolved means of communication between cells. During the formation of the immune synapse (IS), diverse transmembrane and membrane associated molecules are reorganized into a highly segregated structure at the T cell–Antigen-Presenting Cell (APC) contact site. As part of this process, the tubulin cytoskeleton is vectorially directed toward the center of the IS ...
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 2

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Clot formation as a potential diagnostic tool and therapeutic target for Alzheimer's disease (ADvasculature)

Start date: Jan 15, 2015, End date: Jan 14, 2017,

Alzheimer’s disease (AD) is the leading cause of dementia in the elderly. Accumulating evidence links AD with vascular risk factors. These correlations, together with profound alterations of cerebrovascular structure and function present in AD, suggest a “vascular hypothesis”, where vascular pathology eventually leads to neurodegeneration and subsequent cognitive decline. A decrease in cerebral bl ...
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Mitochondrial European Educational Training (MEET)

Start date: Jan 14, 2013, End date: Jan 13, 2017,

"The expanding diversification and specialization of knowledge and the growing complexity of contemporary research in translational research warrant the creation of cooperative multi-disciplinary networks including both basic and medically oriented expertise. This notion is especially true for Mitochondrial Medicine which aims at understanding the physiopathological mechanisms sharing the features ...
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 10

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Role of obesity in the development of hepatocellular carcinoma (OBECAN)

Start date: Dec 1, 2010, End date: Nov 30, 2016,

Obesity is associated with increased risk for epithelial tumors such as hepatocellular carcinoma (HCC). It is not known, however, whether obesity increases the risk for HCC simply because it promotes cirrhosis, a general risk factor for HCC, or through other mechanisms that operate independently of cirrhosis. Among these, obesity is associated with a chronic inflammatory state, with the release of ...
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 1

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Immune Functions of Myeloid Syk-coupled C-type Lectin Receptors Sensing Necrosis (CLR Sensing Necrosis)

Start date: Dec 1, 2010, End date: Aug 31, 2016,

Necrosis triggers an inflammatory response driven by macrophages that normally contributes to tissue repair but, under certain conditions, can induce a state of chronic inflammation that forms the basis of many diseases. In addition, dendritic cell (DC)-mediated presentation of antigens from necrotic cells can trigger adaptive immunity in infection-free situations, such as autoimmunity or therapy- ...
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Caveolin-1 integrates stromal mechanical forces chemo-resitance to foster tumor progression (CAVCER)

Start date: May 1, 2014, End date: Apr 30, 2016,

Breast cancer affects 1 in 8 women and is the chief cause of female cancerdeaths in the EU. Early detection continues to improve survival, but prognosisworsens significantly after metastasis. Metastasis and chemoresistance are linkedphenomena, but the molecular basis is unknown. The evidence suggests a role forCaveolin1 (Cav1): i) Cav1 mediates biomechanical remodelling of the extracellularmatrix ...
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Mitochondrial deficiency and cardiomyopathy. Role of Reactive Oxygen Species (ROLROS)

Start date: Apr 2, 2012, End date: Apr 1, 2016,

"Mitochondrial diseases are now considered to be among the most common forms of genetic disorders, with a minimum prevalence of 1 in 5000 individuals. They can be caused by mutations in either the nuclear or the mitochondrial DNA (mtDNA). One of the most well characterized clinical presentations is neuromuscular dysfunction, followed by cardiomyopathy, generally in the form of hypertrophic cardiom ...
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Regulation of normal and leukaemic stem cells by the microenvironment: role of nestin+ mesenchymal stem cells and humoral signals (LSCMICROENV)

Start date: Feb 1, 2012, End date: Jan 31, 2016,

The presence of self-renewing “cancer stem cells” responsible for tumour initiation and maintenance has been well defined in multiple types of solid and haematologic tumours; however, our knowledge of their biology is very limited. While it is believed that leukaemia stem cells (LSC) – like normal haematopoietic stem cells (HSC) – depend on the interaction with a specialized microenvironment or ‘n ...
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 1

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Translational Training network on the Cellular and Molecular Bases of Heart Homeostasis and Repair (CardioNeT)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

The CardioNeT Initial Training Network aims to implement a highly multidisciplinary, intersectoral and competitive training programme in cardiovascular research through cutting-edge projects and extensive training in complementary areas.CardioNeT training comprises two tightly linked components - research and complementary training - that will be implemented at local as well as network level and ...
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 13

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Homeostatic regulation of mesenchymal stem cells in the haematopoietic stem-cell niche (MSC-HSC NICHE)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

The cells forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear. Our recent studies have demonstrated that mesenchymal stem cells (MSC) identified using expression of the intermediate filament protein nestin constitute an essential HSC niche component. Nestin+ cells contribute to bone formation, contain all the mesenchymal activity and can self-renew and expand in serial ...
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 1

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Living Photonics: Monitoring light propagation through cells (LiPhos)

Start date: Nov 1, 2012, End date: Oct 31, 2015,

LIPHOS is focused on the development of completely innovative biophotonic diagnosis tools, which are for the first time implemented using cells as constituent material. Here, and unlike existing systems, light remains confined in a waveguide whose core is uniquely composed by cells, giving rise to the "Living photonics" concept. In this context, cells play a two-fold role: i) they form the biomate ...
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 8

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CNIC INTERNATIONAL INCOMING FELLOWSHIPS FOR YOUNG GROUP LEADERS (CNIC IIF)

Start date: Oct 1, 2011, End date: Sep 30, 2015,

The CNIC IIF Programme will offer a total of 24 positions during the COFUND programme life (four years) in the incoming mobility type in the area of cardiovascular research.Every year six fellowships will be offered at the level of young group leaders: 4 Starting Fellowships (SF) and 2 Advanced Fellowships (AF). In both cases, the duration of the fellowships will be 3 years and have particular ob ...
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 1

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Cardiac fibrosis versus regeneration: lessons learned from the zebrafish (CAREFISH)

Start date: May 1, 2013, End date: Apr 30, 2015,

Myocardial infarction (MI) leading to ischemic heart disease is the most common cause of death worldwide. In mammals, MI results in the in the replacement of the damaged myocardium with a scar. However, other animals, such as teleost fish have a remarkable capacity to regenerate damaged tissue replacing it with newly formed tissue. Recently, a zebrafish model of MI has been established. Cryoinjury ...
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 1

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Oxygen sensing in cardiovascular progenitors cell fate decisions (Hypoxia & Cell Fate)

Start date: Mar 1, 2011, End date: Feb 28, 2015,

Cardiogenesis is a complex process that involves different cell types that have to mature to form the final functional heart compartments. Isl1 cardiovascular progenitors label the “second heart field” and contribute to myocardial, smooth muscle and endothelial structures of the heart. These progenitors have been extensively studied but little is know about the extracellular signals mediating thei ...
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 1

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Molecular mechanisms of mature B cell lymphomagenesis (BCLYM)

Start date: Dec 1, 2008, End date: Nov 30, 2014,

Most of the lymphomas diagnosed in the western world are originated from mature B cells. The hallmark of these malignancies is the presence of recurrent chromosome translocations that usually involve the immunoglobulin loci and a proto-oncogene. As a result of the translocation event the proto-oncogene becomes deregulated under the influence of immunoglobulin cis sequences thus playing an importan ...
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 2

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Psychosocial Factors and Cardiovascular Disease in Spain (PSYCHO CARDIO SPAIN)

Start date: Nov 1, 2010, End date: Oct 31, 2014,

"The study of the possible associations of psychosocial factors as job strain, depression, social support and stress, with the development, treatment and prognosis of cardiovascular disease (CVD) is a promising research field. Job strain and depression are highly prevalent conditions, and CVD remains to be the first cause of death in most countries around the world. Nevertheless, only a few cardio ...
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 2

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Fixed Dose Combination drugs for Secondary Cardiovascular Prevention (FOCUS)

Start date: Jul 1, 2010, End date: Jun 30, 2014,

Cardiovascular diseases (CVD) are the leading cause of death worldwide, and their incidence is increasing sharply in developing countries. Two insufficiently addressed factors contribute to increased morbidity and mortality, threatening the effectiveness of any health system: poor patient adherence to treatment, and limited access to medication in resource-poor countries and regions. To address th ...
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Role of c-Myc in atherosclerotic macrophages (MycMacs)

Start date: Mar 1, 2012, End date: Feb 28, 2014,

Atherosclerosis and associated cardiovascular disease are the leading causes of mortality in developed countries and the World Health Organization has estimated that by 2020 these disorders will be the main sanitary and socio-economic problem world-wide due in part to the progressive aging of our societies. Atherosclerosis is a complex chronic inflammatory process triggered and perpetuated by card ...
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 2

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LEUKOCYTE MICRODOMAINS AND PLATELET INTERACTIONS IN THROMBO-INFLAMMATORY INJURY (LEMPIT)

Start date: Jan 1, 2010, End date: Dec 31, 2013,

"During the inflammatory response, leukocytes accumulate in the vascular lumen and undergo a morphological and molecular polarization characterized by the formation of discrete domains (a leading edge and an uropod) that allows their directional migration. We aim to understand how and when this polarization originates, as well as the endothelial signals that induce it under physiological condition ...
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 1

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Contribution of RXRs to myeloid cell biology: from hematopoietic stem cells to osteoclastogenesis (RXR in myeloid cells)

Start date: Sep 1, 2010, End date: Aug 31, 2013,

Hematopoietic stem cells (HSCs) yield blood precursors devoted to unilineage differentiation and production of mature blood cells, including red blood cells, megakaryocytes, lymphocytes and myeloid cells. Precursors of the myeloid lineage differentiate into monocytes and granulocytes but at given stages of their maturity they can be also sources of multinucleated osteoclasts. Consequently, any alt ...
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 1

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NOTCH SIGNALING IN DEVELOPMENT AND PATHOLOGY (NotchIT)

Start date: Jan 1, 2009, End date: Dec 31, 2012,

Eight partners from six different EU countries will converge in NotchIT, a multi-site ITN aimed to increase the knowledge of cellular and molecular mechanisms by which Notch signaling regulates the development and pathology of different tissues. Notch signaling plays a key role in cell-fate determination and differentiation of various cell types and aberrant Notch signaling is associated with path ...
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 11

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Role of Calcineurin alternative splicing variant CnAbeta1 in stem cell biology and cardiac development (CARDEB1)

Start date: Oct 1, 2009, End date: Sep 30, 2012,

"The heart is the first organ to form and it is essential for blood distribution during embryogenesis. Congenital heart malformations are the most common birth defect in humans, present in 1 % of the human population worldwide. The calcineurin splicing variant CnAbeta1 is expressed in stem cells, precursors and developing tissues and its expression decreases during tissue maturation. We aim to det ...
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Role of Meis1 in the embryonic megakaryocyte lineage and vascular development (Meis1 & Vascular MK)

Start date: Jun 1, 2010, End date: May 31, 2012,

The main aim of the present project is to provide the first description of embryonic megakaryocyte function during vascular development and maintenance. The recent description of embryonic megakaryocytes existence together with the presence of vascular defects in all mouse mutant models that lack embryonic megakaryocytes suggests that a cellular interaction between embryonic megakaryocytes and end ...
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Hybrid PET-MR system for concurrent ultra-sensitive imaging (HYPERImage)

Start date: Apr 1, 2008, End date: Sep 30, 2011,

The HYPERImage project will develop a novel hybrid system for simultaneous whole-body PET/MR imaging for humans. It will advance the required Time-of-Flight (ToF) PET technology, and the software for MR mediated compensation of motion artefacts. The hybrid system will be validated in pre-clinical and initial clinical studies, for exemplary applications in cardiovascular diseases, and in breast can ...
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Role of PPARgamma in the interstitial fluid volume regulation and contribution to cardiovascular complications of TZDs (PGFC)

Start date: Oct 1, 2009, End date: Sep 30, 2011,

"Thiazolidinediones (TZDs) are clinically proven insulin sensitizers with anti-inflammatory benefits used in the therapy of type 2 diabetes mellitus (T2DM) and atherosclerosis. TZDs can activate a transcription factor, the peroxisome proliferator-activated receptor gamma (PPARg). PPARg regulates expression of several genes involved in inflammatory pathways, lipid transport and carbohydrate metabol ...
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