8 European Projects Found
Searched on 125080 European Projects
FINISHED
Generation of the CanPath prototype - a platform for predictive cancer pathway modeling (CanPathPro)
Start date: Mar 1, 2016, End date: Feb 28, 2021,
Recent developments in omics technologies demand implementation of systems biology approaches to facilitate analysis and interpretation of the generated complex datasets.This is essential for biotechnological as well as preclinical and clinical applications. In comparison to previous approaches, most cancer relevant studies are confined to pattern recognition or at best modelling of single pathway ...
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9
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FINISHED
REgenerative Stem cell therapy for STroke in Europe (RESSTORE)
Start date: Sep 1, 2015, End date: Aug 31, 2020,
Stroke is the second leading cause of death in the world population. When not fatal, stroke often results in disability, due to motor and cognitive impairments, and secondary health problems affecting not only patients but also their families. Building on emerging preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke ...
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29
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FINISHED
Zoonotic Anticipation and Preparedness Initiative (ZAPI)
Start date: Mar 1, 2015, End date: Feb 29, 2020,
Emerging infectious diseases are occurring at increasing frequency in Europe and other regions of the world, having profound impacts on public and/or veterinary health as well as disruptive effects on sector, regional or even global economy. The predominantly zoonotic nature of emerging pathogens calls for a One Health approach uniting the human medical and veterinary fields, dedicated to swiftly ...
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21
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RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research (RD-CONNECT)
Start date: Nov 1, 2012, End date: Oct 31, 2018,
Despite examples of excellent practice, rare disease (RD) research is still mainly fragmented by data and disease types. Individual efforts have little interoperability and almost no systematic connection between detailed clinical and genetic information, biomaterial availability or research/trial datasets. By developing robust mechanisms and standards for linking and exploiting these data, RD-Con ...
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30
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Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL)
Start date: Oct 1, 2013, End date: Sep 30, 2018,
"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth char ...
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19
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FINISHED
Gene Therapy for X-linked Chronic Granulomatous Disease (CGD) (NET4CGD)
Start date: Dec 1, 2012, End date: May 31, 2018,
This project is focused on the clinical development of a new orphan drug that can rapidly become a new treatment option for patients with the X-linked form of chronic granulomatous disease (X-CGD). This rare primary immune deficiency of phagocytes is caused by mutations in the gp91phox gene. Affected patients are highly-susceptible to infections and develop inflammatory granulomas. Several member ...
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11
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FINISHED
Advanced Cell-based Therapies for the treatment of Primary ImmunoDeficiency (CELL-PID)
Start date: Nov 1, 2010, End date: Apr 30, 2016,
Primary immune deficiencies (PID) are inherited disorders of the adaptive and innate immune system marked by severe infections, autoimmunity and high risk of cancer. Treatment entails hematopoietic stem cell (HSC) transplantation from allogeneic donors, however in the absence of an HLA compatible donor, HSCT outcome is limited by delayed or suboptimal reconstitution and complications. SCID-X1 and ...
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20
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FINISHED
Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD)
Start date: Nov 1, 2012, End date: Oct 31, 2014,
Lung transplantation (LT) is the standard of care for selected patients with chronic respiratory failure. Chronic lung allograft dysfunction (CLAD) (i.e. “Bronchiolitis obliterans syndrome” (BOS) and “Restrictive Allograft Syndrome” (RAS)) represents a major health risk for LT recipients, requiring the use of heavy treatments and possible retransplantation. Observed in almost 50% of patients afte ...
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