Search for European Projects

8 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics (GlyCoCan)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

Colorectal cancer (CRC) is a major worldwide cancer burden with about 1.4 million cases in 2012 and an annual mortality of approximately 700,000. Early detection is crucial as treatment is most efficient in early stages where population based screenings could substantially reduce incidence and mortality.Current screening techniques are invasive or lack sensitivity and specificity. Moreover, the mo ...
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 9

 FINISHED 

Epithelial resistance modulation to treat disease (EMODI)

Start date: Oct 1, 2016, End date: Mar 31, 2018,

Epithelial barriers are essential for organism’s homeostasis and survival. Defects in resistance of body barrier epithelial tissues and their repair are thought to underlie a range of diseases, which affect millions. Antonio Jacinto’s group has discovered that Septate/Tight Junctions are essential for epithelial repair. These cell-cell junctions can be potentially targeted by candidate compounds t ...
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 1

 FINISHED 

Mechanisms of synaptic growth and plasticity (Neuronal Trafficking)

Start date: Mar 1, 2016, End date: Feb 28, 2018,

My long-term goal is to understand the cellular and molecular mechanisms that govern synaptic growth and plasticity, and how dysfunction in these pathways contributes to disease. Neurons are the most morphologically diverse cell type whose morphology determines many functional aspects of a neuronal network. The primary shape of a neuron is established during axon and dendrite outgrowth and synapse ...
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 1

 FINISHED 

European Clinical Research Infrastructures Network - Integrating Activity (ECRIN-IA)

Start date: Jan 1, 2012, End date: Dec 31, 2017,

ECRIN is a distributed ESFRI-roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients. Servicing multinational trials started during its preparatory phase, and it now applies for an ERIC status by 2011. The ERIC budget will be restricted to core activities re ...
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 48

 FINISHED 

The molecular physiology and the evolution of a new pathway promoting developmental stability (FLY-PHY)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

Developmental stability is the ability of an organism to buffer given traits against environmental and intrinsic perturbations. This may involve physiological, temporal or behavioral adjustments to the developmental program. The processes leading to developmental stability have been particularly well studied in arthropods. For instance, if uncoordinated growth is induced in the larval imaginal dis ...
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 1

 FINISHED 

The role of neuronal intracellular traffic in Alzheimer´s disease (TRAFFICINAD)

Start date: Apr 1, 2013, End date: Mar 31, 2017,

In neurons of Alzheimer’s disease (AD) there is an aberrant accumulation of beta-amyloid (Aβ) at synapses that renders difficult the formation of new memories for AD patients. Intracellular trafficking abnormalities have been implicated in Aβ accumulation. This research project aims to define how neuronal intracellular trafficking is mechanistically involved in Aβ accumulation that leads to AD. W ...
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 1

 FINISHED 

Role of Arl13b in endocytic trafficking (Arl13b trafficking)

Start date: Oct 1, 2009, End date: Sep 30, 2013,

To move cargo between specific membrane-bound intracellular compartments, eukaryotic cells have evolved numerous mechanisms of membrane trafficking regulation. We found that CD1a, an MHC Class I-like lipid antigen presenting molecule follows an endocytic recycling pathway similar to that used by MHC Class I and other cargo internalized independently of clathrin. In an attempt to discover new regul ...
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 1

 FINISHED 

Optimizing suicide prevention programs and their implementation in Europe (OSPI-Europe)

Start date: Oct 1, 2008, End date: Mar 31, 2013,

Suicide is a serious public health problem in the EU calling for effective interventions. The aim of this project is to provide EU member states with an evidence based prevention concept, concrete materials and instruments for running and evaluating these interventions and recommendations for the proper implementation of the intervention. These aims will be achieved by the following objectives: &g ...
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