Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

 FINISHED 

"Proposal to assess an innovative Immunotherapy, based on a thioredox peptide antigen, in a Phase I Trial for Type-1 Diabetes" (EXALT)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"Type-1 diabetes (T1D) is an autoimmune disease in which pancreatic β-cells are gradually destroyed by autoreactive T-cells recognising autoantigens (Auto-Ag) such as GAD65 and insulin. ImCyse, a small SME, has developed a new technology based on short synthetic peptides flanked with a thioredox motif, which silence the pathogenic immune response against several auto-Ag through activation of one a ...
Read Project

 7

 FINISHED 

DIabetes REsearCh on patient sTratification (DIRECT)

Start date: Feb 1, 2012, End date: Jan 31, 2019,

The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.There is heterogeneity in who develops diabetes, the rate at which th ...
Read Project

 27

 FINISHED 

Wheat and barley Legacy for Breeding Improvement (WHEALBI)

Start date: Jan 1, 2014, End date: Dec 31, 2018,

WHEALBI will combine genomics, genetics and agronomy to improve European wheat and barley production in competitive and sustainable cropping systems. Germplasm representing the species diversity will be selected and characterised in unprecedented detail by next-generation-sequencing. Life history and adaptive traits will be evaluated in both transnational field experiments and a state-of-the-art p ...
Read Project

 20

 FINISHED 

Multi-dimensional omics approach to stratification of patients with low back pain (PAIN-OMICS)

Start date: Sep 1, 2013, End date: Aug 31, 2018,

"Pain-OMICS is a multidisciplinary consortium of leading clinical, academic and SME researchers in pain and different omics technologies. Genome-wide association studies identified a number of loci associated with pain, but the level of knowledge about underlying mechanisms of different pain syndromes as well as individual variation in the disease course remains inadequate. Pain-OMICS will capital ...
Read Project

 11

 FINISHED 

Phytoremediation driven energy crops production on heavy metal degraded areas as local energy carrier (Phyto2Energy)

Start date: Feb 1, 2014, End date: Jan 31, 2018,

The scientific and technological (S&T) goal of the project is to develop and validate an innovative approach combining phytoremediation and production of biomass on heavy metal contaminated (HMC) areas which could be used as local energy carrier. The S&T objectives of the project are as follows: Objective1) selection of optimal plant species suitable for phytoremediation driven energy crops produc ...
Read Project

 6

 FINISHED 

Reverse engineering the vertebrate molecular machinery for magnetic biomineralisation (MagnetoGenetics)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

In order to understand distributed biological networks and invent effective molecular therapies, we need to be able to image and control molecular processes across entire live organisms.Although an arsenal of genetically encoded fluorescent sensors and light-activated proteins has recently been developed to visualize and manipulate cellular activity, these methods all suffer from the poor penetrat ...
Read Project

 2

 FINISHED 

Organic Bioelectronics (ORGBIO)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

Organic Bioelectonics is a new discipline which holds promise to shape, direct, and change future medical treatments in a revolutionary manner over the next decades. At the moment Europe has a unique leading position in this area, being almost all the world-leading groups in this field located in Europe and constituting the core of this international training network. However, realizing the promis ...
Read Project

 15

 FINISHED 

Identification and validation of novel pharmaceutical drug targets for cardiovascular disease (CARTARDIS)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

"Cardiovascular disease (CVD) is one of the major diseases in Europe and the Western world, killing over 2 million people per year in Europe alone and is the foremost cause of premature mortality and disability-adjusted life years, representing an annual economic cost of ∼€ 192 billion in direct and indirect healthcare expenses. The available therapies are insufficient to fulfill the need. The int ...
Read Project

 13

 FINISHED 

Clinical and system –omics for the identification of the MOlecular DEterminants of established Chronic Kidney Disease (iMODE-CKD)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical researc ...
Read Project

 10

 FINISHED 

Specificity of Rc3h1/2 proteins in post-transcriptional control of immunity and autoimmune disease (RC3H1/2-SPECIFICITY)

Start date: Nov 1, 2011, End date: Oct 31, 2016,

We are constantly protected by our adaptive immune system. Its functioning requires precise control of gene expression in lymphocytes, since deregulation can cause autoimmune diseases (affecting ~5% of our population) as well as allergic reactions (~9-16%, with increasing incidence). Post-transcriptional control of gene expression is crucial in many immune decisions, however the determinants of sp ...
Read Project

 2

 FINISHED 

European Medicines Research Training Network (EMTRAIN)

Start date: Oct 1, 2009, End date: Sep 30, 2016,

EMTRAIN is an essential element for the success of the IMI Education & Training (E&T) Call Topics in Europe (current and future). It will establish a pan-European platform of excellence for education and training covering the whole life-cycle of medicines from basic research through clinical development to pharmaco-vigilance. It will underpin the successful delivery of the current and future IMI-f ...
Read Project

 32

 FINISHED 

European-study on Quantifying Utility of Investment in Protection from Tobacco (EQUIPT)

Start date: Oct 1, 2013, End date: Sep 30, 2016,

Tobacco smoking costs the EU an estimated 98 to 130 billion Euros each year – just above 1% of the EU Gross Domestic Product in 2000. A large, robust and consistent evidence base indicates that coordinated, high impact and comprehensive approaches are the most effective way to reduce smoking initiation, prevalence and intensity. Despite this, policy makers and public health procurers often lack th ...
Read Project

 11

 FINISHED 

OPtimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) (OPTiMiSE)

Start date: Feb 1, 2010, End date: Jul 31, 2016,

OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project wi ...
Read Project

 25

 FINISHED 

Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling (AirPROM)

Start date: Mar 1, 2011, End date: Jun 30, 2016,

The airways diseases asthma and chronic obstructive pulmonary disease affect over 400 million people world-wide and cause considerable morbidity and mortality. Airways disease costs the European Union in excess of €56 billion per annum. Current therapies are inadequate and we do not have sufficient tools to predict disease progression or response to current or future therapies. Our consortium, Air ...
Read Project

 40

 FINISHED 

Priming epithelial cell activation to regenerate the lung (PEARL)

Start date: Apr 1, 2011, End date: Mar 31, 2016,

Chronic obstructive pulmonary disease (COPD), a global health problem, will be the third leading cause of death by 2020. No effective therapy exists for COPD, which is characterized by a progressive loss of lung tissue, in particular functional alveolar epithelium, due to the inability of the lung to regenerate. Thus, regeneration of functional lung tissue would be a tremendous step forward, which ...
Read Project

 1

 FINISHED 

Studies on a cohort of Serbian children exposed to x-irradiation to determine the contribution of the non-coding genome to susceptibility at low doses (DARK.RISK)

Start date: Oct 1, 2012, End date: Mar 31, 2016,

"The epidemiological study of Tinea capitis (ringworm) patients has proven useful for the study of carcinogenic effects of low dose radiation. In Dark.risk we will develop a new epidemiological cohort based upon the 24 000 cases irradiated in childhood that we will document to create the Serbian Registry of Tinaea Capitis Children (SRTCC). Unlike many other epidemiological cohorts SRTCC can be use ...
Read Project

 5

 FINISHED 

Modelling latent causes in molecular networks (LATENTCAUSES)

Start date: Jan 1, 2011, End date: Mar 31, 2016,

In systems biology, we aim at deriving gene-regulatory or signaling models based on multivariate readouts, thereby generating predictions for novel experiments. However any model only approximates reality, leaving out details or other types of regulation. Here I ask why a given model fails to predict a set of observations with acceptable accuracy and how to refine the model using this experimental ...
Read Project

 1

 FINISHED 

Low Dose Research towards Multidisciplinary Integration (DOREMI)

Start date: Jan 1, 2010, End date: Dec 31, 2015,

The aim of DoReMi is to promote the sustainable integration of low dose risk research in Europe in order to aid the effective resolution of the key policy questions identified by the High Level Expert Group (HLEG) on Low Dose Risk Research (www.hleg.de). DoReMi provides an operational tool for the development of the proposed MELODI platform (Multidisciplinary European Low Dose Risk Re-search Initi ...
Read Project

 39

 FINISHED 

SUrrogate markers for vascular Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT)

Start date: Nov 1, 2009, End date: Oct 31, 2015,

Diabetes mellitus is a lifelong, incapacitating disease affecting multiple organs. Worldwide prevalence figures estimate that there will be 246 million diabetic patients in 2007 and 380 million in 2025. Presently, diabetes can neither be prevented nor cured and the disease is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular disease) as we ...
Read Project

 27

 FINISHED 

Deep Tissue Optoacoustic Imaging for Tracking of Dynamic Molecular and Functional Events (DYNAMIT)

Start date: Oct 1, 2010, End date: Sep 30, 2015,

The ability to visualize biological processes in living organisms continuously, instead of at discrete time points, holds a great promise for studies of functional and molecular events, disease progression and treatment monitoring. Optical spectrum is particularly attractive for biological interrogations as it can impart highly versatile contrast of cellular and sub-cellular function as well as em ...
Read Project

 1

 FINISHED 

Uncovering the mechanisms of inflammation induced liver tissue destruction and carcinogenesis (LIVERCANCERMECHANISM)

Start date: Oct 1, 2010, End date: Sep 30, 2015,

Hepatocellular carcinoma (HCC) is caused by chronic hepatitis and is the third most common cause of cancer-related death worldwide, with a rising incidence in first world countries. To date no effective therapies other than liver transplantation are available for this disease.Previous studies have provided evidence that inflammatory signalling pathways (e.g. the NF-b pathway) are crucial modulato ...
Read Project

 1

 FINISHED 

A pan-European infrastructure for quality in nanomaterials safety testing (QUALITYNANO)

Start date: Feb 1, 2011, End date: Jul 31, 2015,

Nanoscale objects interact with living organisms in a fundamentally new manner, ensuring that a fruitful marriage of nanotechnology and biology will long outlast short term imperatives. Therefore, investment in an infrastructure to drive scientific knowledge of the highest quality will have both immediate benefits of supporting the safety assessment of legacy nanomaterials, as well as pointing tow ...
Read Project

 33

 FINISHED 

Mechanisms of the Development of ALLergy (MEDALL)

Start date: Dec 1, 2010, End date: May 31, 2015,

Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL (Mechanisms of the Development of Allergy) aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational app ...
Read Project

 24

 FINISHED 

Infectious triggers of chronic autoimmunity (INTRICATE)

Start date: Nov 1, 2010, End date: Apr 30, 2015,

This proposal builds on existing expertise and collaborations of a multidisciplinary Consortium of basic scientists and clinical investigators each of whom has made a substantial individual contribution to understanding the links between infection and autoimmunity. The aim of the INTRICATE Consortium is to prosecute a programme of Translational Research that deliniates the role of infection in the ...
Read Project

 13

 FINISHED 

Deciphering mechanisms of ciliary disease (CiliaryDisease)

Start date: Feb 1, 2010, End date: Jan 31, 2015,

Ciliopathies are pleiotropic diseases with a wide spectrum of human phenotypes. These include cyst formation in the liver and pancreas, respiratory disorders and a predisposition to diabetes and cancer. The pleiotropic nature of these disorders may reflect the many roles cilia play in physiology and signalling, highlighting the clinical importance of understanding their function in organ developme ...
Read Project

 1

 FINISHED 

"CATO - CBRN crisis management: Architecture, Technologies and Operational Procedures" (CATO)

Start date: Jan 1, 2012, End date: Dec 31, 2014,

"CATO proposes to develop a comprehensive Open Toolbox for dealing with CBRN crises due to terrorist attacks using non-conventional weapons or on facilities with CBRN material. CATO will:• combine CBRN knowledge, planning & response know-how, DSS building blocks and dedicated models and algorithms• enable the development of specific holistic CBRN-DSS• cover the entire CBRN disaster life cycle from ...
Read Project

 28

 FINISHED 

PREvention of Late Stent Thrombosis by an Interdisciplinary Global European effort (PRESTIGE)

Start date: Dec 1, 2010, End date: Nov 30, 2014,

"According to the European Society of Cardiology there has been an increase in the life expectancy at the age of 65 of the European population from 15.0 to 17.0 years in the years since 1980. In the elderly, up to 50% of deaths are caused by cardiovascular diseases, the majority accounted for by coronary artery disease. The most effective treatment for obstructive coronary disease is percutaneous ...
Read Project

 16

 FINISHED 

Reduction of Suicides and Trespasses on RAILway property (RESTRAIL)

Start date: Oct 1, 2011, End date: Sep 30, 2014,

The aim of the RESTRAIL project is to reduce the occurrence of suicides and trespasses on railway property and the costly service disruption these events cause, by providing the rail industry with an analysis and identification of cost-effective prevention and mitigation measures.The project starts by identifying the state of the art of best practices and research findings (inside and outside Euro ...
Read Project

 19

 FINISHED 

Next Generation in-vivo imaging platform for post-genome biology and medicine (MSOT)

Start date: Mar 1, 2009, End date: Jun 30, 2014,

With re-defined challenges in post-genome biology and medicine related to understanding the regulation and function of genes, proteins and multi-factorial disease, the development of accelerated and quantitative in-vivo observation of functional -omics at different system levels becomes a vital target. This proposal offers to develop therefore a next-generation biomedical imaging platform, designe ...
Read Project

 2

 FINISHED 

Groundwater and dependent Ecosystems: NEw Scientific basIS on climate change and land-use impacts for the update of the EU Groundwater Directive (GENESIS)

Start date: Apr 1, 2009, End date: Mar 31, 2014,

Groundwater resources are facing increasing pressure from consumptive uses (irrigation, water supply, industry) and contamination by diffuse loading (e.g. agriculture) and point sources (e.g. industry). This cause major threat and risks to our most valuable water resource and on ecosystems dependent on groundwater. New information is need on how to better protect groundwaters and groundwater depen ...
Read Project

 28

 FINISHED 

“Effect of diet on the mental performance of children” (NUTRIMENTHE)

Start date: Mar 1, 2008, End date: Dec 31, 2013,

Current evidence on the effect of diet on mental performance (MP) is largely based on animal, retrospective studies, and short-term nutritional intervention studies in humans. NUTRIMENTHE will significantly improve this knowledge through studying the role, mechanisms, risks & benefits of specific nutrients & food components to respond to specific needs and improve the MP of children. The research ...
Read Project

 22

 FINISHED 

Genetic testing in Europe - Network for the further development, harmonization, validation and standardization of services (EUROGENTEST2)

Start date: Jan 1, 2011, End date: Dec 31, 2013,

EuroGentest is an FP6 European network for the harmonization of genetic testing and for the further improvement of quality in genetic services across Europe.This proposal is to support EuroGentest2, a Coordination Action that will cover the different aspects of quality assurance of genetic practice and has all the ingredients to fulfil the needs. EuroGentest2 will be concerned with setting the tar ...
Read Project

 22

 FINISHED 

Development of rehabilitation technologies and approaches for multipressured degraded waters and the integration of their impact on river basin management (AQUAREHAB)

Start date: May 1, 2009, End date: Dec 31, 2013,

Within the AQUAREHAB project, different innovative rehabilitation technologies for soil, groundwater and surface water will be developed to cope with a number of hazardous (nitrates, pesticides, chlorinated and aromatic compounds, mixed pollutions,…) within heavily degraded water systems. The technologies are activated riparian zones/wetlands; smart biomass containing carriers for treatment of wa ...
Read Project

 19

 FINISHED 

Sharing capacity across Europe in high-throughput sequencing technology to explore genetic variation in health and disease (GEUVADIS)

Start date: Oct 1, 2010, End date: Dec 31, 2013,

"High-throughput next-generation DNA sequencing technologies allow investigators to sequence entire human genomes at an affordable price and within a short time frame. The correct interpretation, storage, and dissemination of the large amount of produced genomics data generate major challenges. Tackling these challenges requires extensive exchange of data, information and knowledge between medical ...
Read Project

 17

 FINISHED 

European Collaborative Project on Inflamation and Vascular Wall Remodelling in Atherosclerosis (ATHEROREMO)

Start date: May 1, 2008, End date: Oct 31, 2013,

"The health of the EC population has never been better. However, serious public health problems remain, which cannot be ignored including high levels of premature death due to cardiovascular diseases. Thus, new preventive, diagnostic and therapeutic strategies against atherosclerotic cardiovascular diseases are needed. The atherosclerotic changes of the vascular wall are central in the developmen ...
Read Project

 19

 FINISHED 

“The International Data Coordination Centre” (I-DCC)

Start date: Jan 1, 2009, End date: Sep 30, 2013,

"The I-DCC coordination and support project responds to the topic defined by HEALTH-2007-2.1.2-6 “International activities in large-scale data gathering and systems biology”. I-DCC integrates European skills, efforts, resources, and infrastructure in an international collaborative programme to establish a European Data Coordination Centre for mouse genetic resources. Large-scale mouse mutagenesis ...
Read Project

 10

 FINISHED 

European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs (EurOCHIP)

Start date: Oct 1, 2009, End date: Sep 30, 2013,

The past decade has seen tremendous progress in our understanding of homeostatic regulators controlling energy balance. Insights from human and murine genetics have illuminated multiples pathways within the hypothalamus, brainstem and higher brain regions that play a key role in the control of food intake, whilst physiological studies focusing on the gastrointestinal tract have revealed a panoply ...
Read Project

 10

 FINISHED 

Innovative Techniques and Models to Study Glia-Neuron Interactions (EdU-GLIA)

Start date: Sep 15, 2009, End date: Sep 14, 2013,

It became evident over the last 20 years that glial cells are involved in virtually every aspect of nervous system function. Neurons and glia exchange chemical signals that are essential for the normal function of the nervous system, and are crucial in disease. Recently it was discovered that glial cells also act as neural stem cells both in early development and adulthood, and in synapse formatio ...
Read Project

 14

 FINISHED 

Proteomics Standards International Molecular Exchange - Systematic Capture of Published Molecular Interaction Data (PSIMEx)

Start date: Mar 1, 2009, End date: Aug 31, 2013,

The aim of the PSIMEx proposal is to systematically make published molecular interaction data computationally accessible. We plan to further develop the existing standard for molecular interactions developed by the HUPO Proteomics Standards Initiative, and to promote its implementation in the entire chain from experiment planning via data formatting and analysis to data representation in journal p ...
Read Project

 15

 FINISHED 

Multi-disciplinary biodosimetric tools to manage high scale radiological casualties (MULTIBIODOSE)

Start date: May 1, 2010, End date: Apr 30, 2013,

"In the event of a large scale radiological emergency biological dosimetry is an essential tool that can provide timely assessment of radiation exposure to the general population and enable the identification of those exposed people, who should receive medical treatment. A number of biodosimetric tools are potentially available, but they must be adapted and tested for a large-scale emergency scena ...
Read Project

 17