Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

 FINISHED 

A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer (GANNET53)

Start date: Oct 1, 2013, End date: Mar 31, 2019,

"Epithelial ovarian cancer (EOC) is the most lethal gyncaecological malignancy causing 41900 deaths annually in Europe. The predominance of aggressive Type II tumours, which are characterised by a high frequency of p53 mutations, and primary or acquired resistance to platinum-based chemotherapy profoundly contribute to the high mortality rate. With current standard therapy the median overall survi ...
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 20

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THE MILESTONE PROJECT: Managing the Link and Strengthening Transition from Child to Adult Mental Health Care (MILESTONE)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

Transition to adulthood is the period of onset of most of the serious mental disorders that disable or kill in adult life. Current service configuration of distinct Child and Adolescent Mental Health (CAMHS) and Adult Mental Health (AMHS) Services is considered the weakest link where the care pathway should be most robust. Transition-related discontinuity of care is a major socioeconomic and socie ...
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 14

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Heart OMics in AGEing (HOMAGE)

Start date: Feb 1, 2013, End date: Jan 31, 2019,

As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing ...
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 22

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Social innovation to improve physical activity and sedentary behaviour through elite European football clubs: European Fans in Training (EuroFIT)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Concept and aim: 20 million fans attend top division football games each week and many more watch on TV. Our social innovation is to attract people to lifestyle change through the personal connection and loyalty to the club they support. Our aim is to use this social innovation to change physical activity and sedentary behaviour, specially targeting low-SES groups, and men as well as women. EuroFI ...
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 13

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Labeling of Enalapril from Neonates up to Adolescents (LENA)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Children are often treated as small adults—not as the special patients they are. Regulations exist to encourage the development of drugs and formulation for children. However, off-patent drugs are often administered to children without appropriate formulations or systematic investigations. Therefore, the paediatric use marketing authorisation (PUMA) has been designed.The EMA Paediatric Working Par ...
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 14

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Transmembrane Molecular Machines (TRANSPORET)

Start date: Sep 1, 2013, End date: Aug 31, 2018,

This research programme is dedicated to the development of rationally designed transmembrane molecular machines. Proteins that undergo nanomechanical transitions to facilitate transmembrane communication, or that operate as transmembrane pumps, rotary motors, and molecular transporters are ubiquitous in nature. Despite much progress in the development of solid-state and chemical nanomechanical dev ...
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 2

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Consortium on Organ Preservation in Europe (COPE)

Start date: Jan 1, 2013, End date: Jun 30, 2018,

The discrepancy between organ supply and demand remains the biggest challenge facing the transplant community today. In order to increase the amount of available donor organs, transplant specialists are increasingly turning to sub-optimal donor organs. Organs from such donors, usually have normal or near normal function before death, but retrieval, storage and transplantation cause progressive inj ...
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 16

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Development of an artificial information system (XNA)

Start date: Apr 1, 2013, End date: Mar 31, 2018,

"Artificial genetic sequences have become an important tool for the development of new therapeutics but may also define a trait of technological innovation. The possibility to synthesize genes, plasmids and chromosomes combined with the possibilities of directed mutagenesis and genetically reprogramming organisms and directing their evolution will become a crucial issue in synthetic biology. The u ...
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 2

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Biomarkers of renal graft injuries in kidney allograft recipients (BIOMARGIN)

Start date: Mar 1, 2013, End date: Feb 28, 2018,

In renal allograft recipients, 10-year graft survival has not improved over the past decades. Histological examination of graft biopsies has long been the gold standard to confirm graft injuries, but biopsies are invasive and histological grading is not very robust. There is thus a need for robust, non-invasive methods to predict and diagnose acute and chronic graft lesions, to improve patient tre ...
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 13

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Management of Hypotension In the Preterm Extremely Low Gestational Age Newborn (THE HIP TRIAL)

Start date: Oct 1, 2010, End date: Sep 30, 2017,

Assuming an annual birth rate of 10.25 births/1,000 population approximately 25,000 Extremely Low Gestational Age Newborns are born every year in the EU. Conservative figures estimate that approximately half of all these babies will develop low blood pressure and require treatment. However, no uniform criteria exist to define hypotension and the evidence to support our current management strategie ...
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 17

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Oral biopharmaceutics tools (ORBITO)

Start date: Oct 1, 2012, End date: Sep 30, 2017,

The OrBiTo project will deliver novel methods and a framework for rational application of predictive biopharmaceutics tools for oral drug delivery. This will be achieved through novel propsective studies to define new methodlogies which will be validated using historical datasets from EFPIA partners. A combination of high quality in vitro or in silico characterizations of API and formulations will ...
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 28

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BIOIMAGE-Neuromuscular Diseases (BIOIMAGE-NMD)

Start date: Oct 1, 2013, End date: Mar 31, 2017,

BIOIMAGE-NMD will develop and apply imaging technology to monitor response to novel therapies in neuromuscular diseases (NMD) and will use Duchenne muscular dystrophy (DMD) as an exemplar disease. DMD is well characterised genetically and clinically but to date a disease modifying treatment is not available. One of the most promising developments for future treatment of NMD is RNA modulation throu ...
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 9

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Impact of Prenatal Stress on BRAIN AGEing (BRAINAGE)

Start date: Mar 1, 2012, End date: Feb 28, 2017,

Healthy brain ageing is a major determinant of quality life-long health, allowing integration into society at all ages. Human epidemiological and animal studies indicate that in addition to life style and genetic factors, environmental influences in prenatal life have a major impact on brain ageing and age-associated brain disorders. We hypothesize that: (1) prenatal stress programs early brain ag ...
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 10

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Identifying best practices for care-dependent elderly by Benchmarking Costs and outcomes of community care (IBENC)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

Problem:The need for cost effective health systems in Europe is imperative in the context of an increasing demand for health care by growing numbers of elderly people and a shrinking working force. Many health care systems are changing and looking for mechanisms to ensure, measure and improve the quality of care. On the other hand it is unclear which models of care delivery are the most cost-effec ...
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 8

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Patient-centered palliative care pathways in advanced cancer and chronic disease (INSUP-C)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

Integrated delivery systems of care, e.g. networks of health organizations and professionals who work together to coordinate services to meet their patients’ needs, are an important way of linking fragmented services and maximizing system efficiency and seamlessness of patient transition. Research increasingly shows that patients with advanced cancer and advanced chronic disease are treated well ...
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 11

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OPtimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) (OPTiMiSE)

Start date: Feb 1, 2010, End date: Jul 31, 2016,

OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project wi ...
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 25

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Alternative Energy Forms for Green Chemistry (ALTEREGO)

Start date: Jan 1, 2013, End date: Jun 30, 2016,

"The ALTEREGO project aims at overcoming the existing bottlenecks towards implementation of alternative energy technologies for intensified chemical manufacturing. We plan to establish a new hierarchical methodology towards enabling highly efficient chemical syntheses with alternative energy forms through reliable process data collection with advanced analytical tools, robust multiscale modeling a ...
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 8

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Adaptive Brain Computations (ABC)

Start date: Jun 1, 2012, End date: May 31, 2016,

Adaptive interactions with the environment depend on sophisticated brain plasticity mechanisms at multiple levels: from single neurons to large-scale brain networks. Traditionally, the study of plasticity has been fragmented into sensory, motor or decision-related circuits. However, translating brain plasticity findings to brain repair requires an understanding of the interactions between these ci ...
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 10

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Markers for Sub-Clinical Cardiovascular Risk Assessemnt (EU-MASCARA)

Start date: Dec 1, 2011, End date: May 31, 2016,

EU-MASCARA is a collaborative project that aims to improve diagnosis of cardiovascular diseases and prediction of cardiovascular risk by analysing a panel of biomarkers. EU-MASCARA aims to examine genetic, proteomic and metabolomic markers together with markers of inflammation, oxidative stress and cardiac remodelling to study their incremental diagnostic and predictive value over and above existi ...
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 16

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Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects (ADDUCE)

Start date: Nov 1, 2010, End date: Apr 30, 2016,

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children, affecting approximately 5% children in Europe. Methylphenidate (MPH) is the most-commonly prescribed medication for ADHD children; it is also increasingly used in ADHD adults. In 2007, the European Commission requested a referral to the Committee for Medicinal Products for Human Use ...
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 17

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European Training Network for Excellence in Molecular Imaging in Diabetes (BETATRAIN)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

Currently, 180 million people suffer from diabetes worldwide and this number is expected to double until 2030. Diabetes-related healthcare costs may rise to 40% of the total healthcare budget in high incidence countries. Despite these daunting numbers, our knowledge about the pathophysiology of T1D and T2D remains limited and many questions about the relation of the of the beta cell mass, the beta ...
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 10

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HEPATIC MICROFLUIDIC BIOREACTOR (HEMIBIO)

Start date: Jan 1, 2011, End date: Dec 31, 2015,

The goal of HeMiBio is to develop a hepatic microfluidic bioreactor from human iPSC-derived hepatocytes, hepatic sinusoidal endothelial cells (HSEC) and stellate cells (HSC), suitable for inclusion in a repeated dose toxicity testing strategy of pharmaceuticals/cosmetic ingredients. The successful creation of such a liver-device requires (a) homotypic and heterotypic interactions between the three ...
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 13

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Vitamin D And LIfestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention (DALI)

Start date: Mar 1, 2010, End date: Dec 31, 2015,

Europe is facing a rapidly growing threat from Type 2 diabetes mellitus (T2D), which is undoubtedly associated with an unhealthy diet and a more sedentary lifestyle. Evidence is accumulating that gestational diabetes mellitus (GDM) may be playing a role in this process. Thus it provides a significant opportunity for preventing future T2D. Not only is GDM prevalence on the rise, but intrauterine ex ...
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 18

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European Network of Knowledge Transfer in Health (ENTENTE)

Start date: Sep 1, 2012, End date: Aug 31, 2015,

The objective the ENTENTE project is to reinforce knowledge transfer (KT) offices in universities, public research organisations, hospitals and to promote industry academia transnational collaboration in the health sector. This will be achieved through seven sub-objectives:1-The development of a web platform for shared learning and networking including best practices, video interviews, networking ...
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 7

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European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)

Start date: May 1, 2010, End date: Apr 30, 2015,

The aim of EU-GEI is to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia (EU-GEI, Schiz. Res. 2008; 102: 21-6). In order to identify these interactive determinants, EU-GEI will employ family-based, multidisciplinary research paradigms, which allow for the efficient assessment of gene-environment interaction ...
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 27

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European Friedreich's Ataxia Consortium for Translational Studies (EFACTS)

Start date: May 1, 2010, End date: Apr 30, 2015,

EFACTS (the European Friedreich’s Ataxia Consortium for Translational Studies) assembles a body of expertise to adopt a translational research strategy for the rare autosomal recessive neurological disease, Friedreich’s ataxia (FRDA). FRDA is a severely debilitating disease that leads to loss of the ability to walk and dependency for all activities. Some patients have cardiomyopathy that can cause ...
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 15

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Small-molecule Inhibitor Leads Versus emerging and neglected RNA viruses (SILVER)

Start date: Oct 1, 2010, End date: Mar 31, 2015,

RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europe’s and Asia’s leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design ...
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 25

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Crimean Congo Hemorrhagic Fever; Modern Approaches to Diagnostics, Surveillance, Prevention, Therapy and Preparedness (CCH Fever)

Start date: Oct 1, 2010, End date: Mar 31, 2015,

Over the last years, large outbreaks of Crimean Congo Hemorrhagic fever virus (CCHFV) in several European countries and neighbouring areas are on the rise. This disease poses a great threat to public health due to its high mortality rate, modes of transmission and geographical distribution. Climate changes and observation of the CCHFV vector in central Europe alarm the European community as we can ...
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 18

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Determining Optimal non-invasive Parameters for the Prediction of Left vEntricular morphologic and functional Remodeling in Chronic Ischemic Patients (DOPPLER-CIP)

Start date: May 1, 2009, End date: Feb 28, 2015,

Coronary artery disease (CAD) remains the primary cause of cardiovascular morbidity and mortality in Europe. In current clinical practice, patients with chronic CAD are followed using non-invasive imaging methodologies for possible adverse morphologic remodelling and functional recovery of the myocardium before the decision for invasive examinations and treatments is taken. Technological developm ...
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 10

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A Modular Nanosystems Platform for Advanced Cancer Management: Nano-vehicles; Tumor Targeting and Penetration Agents; Molecular Imaging, Degradome based Therapy (SAVEME)

Start date: Mar 1, 2011, End date: Feb 28, 2015,

SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or th ...
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 23

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IMplementation of quality indicators in PAlliative Care sTudy (IMPACT)

Start date: Feb 1, 2011, End date: Jan 31, 2015,

"New knowledge is not necessarily readily applied in medicine, even when there is evidence of its effectiveness. As a result of the gap between knowing and doing, policy makers, professional care providers, patients and their families have benefited too little from new developments. Implementation research has developed models for stepwise implementation but it is still unclear which strategies ar ...
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 14

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Development of OPN-305 as an orphan drug for the treatment of Delayed Graft Function post solid organ transplantation (MABSOT)

Start date: Dec 1, 2010, End date: Sep 30, 2014,

Delayed graft function (DGF) is defined as the need for dialysis within seven days of renal transplantation (DGF promotes allograft rejection, requires prolonged dialysis and hospitalisation, and increases the likelihood of graft failure and ultimately the duration of renal graft survival-expectancy. The incidence of DGF occurs in 21-44% of cases following cadaveric renal graft. Several rare dise ...
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 10

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Development of novel diagnostic and therapeutic approaches to improve patient outcome in lung and pancreatic tumours (CANCERALIA)

Start date: Apr 1, 2011, End date: Sep 30, 2014,

Lung and pancreatic cancers still have a mortality rate over 85% at 5 years of diagnosis, a clear demonstration of the actual treatment failure and the need for improved clinical management. This involves better tools for diagnosis, prognosis, and selection of sensitive and resistant patients to current conventional therapies or improved innovative treatments as well as the development of novel th ...
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 8

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Experimental and Numerical Analyses of the Dynamic Behavior of Rolling Tires in order to Improve the Tire Modeling Accuracy (TIRE-DYN)

Start date: Sep 1, 2010, End date: Aug 31, 2014,

The increasing complexity and shorter development times of vehicles require more accurate and efficient simulation tools. Already in the early phases of the vehicle development, a reliable prediction of the tire dynamic behavior is required to assess and optimize vehicle performances, such as, tire/road noise, handling, ride comfort, vehicle NVH (Noise, Vibration and Harshness) and durability. In ...
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 3

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Exploring Marine Resources for Bioactive Compounds: From Discovery to Sustainable Production and Industrial Applications (MAREX)

Start date: Aug 1, 2010, End date: Jul 31, 2014,

"Biodiversity in the seas is only partly explored, although marine organisms are excellent sources for many industrial products. Through close co-operation between industrial and academic partners, the MAREX project will collect, isolate and classify marine organisms, such as micro- and macroalgae, cyanobacteria, sea anemones, tunicates and fish from the Atlantic, Pacific and Indian Oceans as well ...
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 21

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Clinical development of Enzyme Replacement Therapy in alpha-Mannosidosis patients using recombinant human enzyme (ALPHA-MAN)

Start date: Oct 1, 2010, End date: Mar 31, 2014,

Alpha-Mannosidosis is a rare Lysosomal Storage Disorder with a worldwide incidence of about 1:500 000. This orphan and devastating disease is caused by the deficiency of the lysosomal alpha-mannosidase (LAMAN) which is responsible for the intralysosomal degradation of mannosyl linked oligosaccharides. To date no causative treatment for alpha-Mannosidosis is available and since most of the children ...
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 12

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The appropriateness of prescribing antibiotics in primary health care in Europe with respect to antibiotic resistance (APRES)

Start date: Oct 1, 2009, End date: Mar 31, 2014,

"The APRES project aims at providing information and recommendations on the appropriateness of prescribing antibiotics in primary care. The appropriateness of prescribing antibiotics is the extent to which the pattern of prescribed antibiotics is congruent with the antibiotic resistance pattern of bacteria. More than 90% of antibiotics in Europe is prescribed to non-hospitalized patients, but exis ...
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 16

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A multi-technological approach for Dematerialising the production systems within a view of productive, reliable and eco-efficient machining processes (DEMAT)

Start date: Jul 1, 2010, End date: Dec 31, 2013,

The aim of this project is to dematerialise the machine tools and manufacturing systems that are designed and produced in Europe. Today, European machine builders, the vast majority of them SMEs, sell high performance and productive, but heavy, long-delivery-time and high-energy-consuming machines. The DEMAT project will provide these European companies with knowledge-based technologies and tools ...
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 17

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SUPERSONIC DEPOSITION OF NANOSTRUCTURED SURFACES (SUPERSONIC)

Start date: Dec 1, 2009, End date: Nov 30, 2013,

"The basic scientific and technological concept of the project is to use agglomerated nanophased powders to be transferred onto a substrate in the form a coating with very little or none change of crystal structure. This will allow to obtain nano-structured coatings with a crystal size very close to the powder one. The concept will be extended to an important breakthrough concept that is the “Sup ...
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 12

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SUPramolEculaR functional nanoscale archItectures for Organic electronics: a host-driven network (SUPERIOR)

Start date: Oct 1, 2009, End date: Sep 30, 2013,

SUPERIOR aims at providing top-quality cross-disciplinary and supra-sectoral training to a pool of promising young researchers, in an area at the interface between Supramolecular Chemistry, Materials- and Nano-Science, Physics and Electrical Engineering. SUPERIOR appointees will be formally trained in lecture courses, dedicated schools and workshops, and through an ambitious and carefully planned ...
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