3 European Projects Found
Searched on 125080 European Projects
FINISHED
Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation, in health and disease (4DCELLFATE)
Start date: Dec 1, 2011, End date: Nov 30, 2016,
Embryonic stem (ES) cells have the potential to differentiate into any type of cell as well as to renew indefinitely in culture. They hold great potential for the development of personalized medicines. However, the molecular mechanisms underpinning cell fate decisions by individual cells are poorly understood. There is compelling evidence that two large multi-protein machines, the Nucleosome Remod ...
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13
Partners Participants
FINISHED
Epilepsy Pharmacogenomics: delivering biomarkers for clinical use (EpiPGX)
Start date: Nov 1, 2011, End date: Oct 31, 2015,
The purpose of the project is to identify genome-based biomarkers for use in clinical practice to individualise treatment of epilepsy, and stratify patients for clinical trials, aiming to avoid chronicity, prevent relapse and reduce adverse drug reactions (ADRs).The need for improved treatments in epilepsy is undoubted. Epilepsy is affects 50,000,000 people of all ages worldwide. Epilepsy is serio ...
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15
Partners Participants
FINISHED
Towards FXR-mediated therapeutic intervention: Understanding how FXR integrates metabolic, endocrine and inflammatory signaling (mechFXR)
Start date: Apr 1, 2012, End date: Mar 31, 2014,
Nuclear receptors (NRs) are ligand-activated transcription factors that play vital roles in human physiology. 13% of all FDA-approved drugs target NRs, however they are associated with side-effects that limit their utility and safety. These side-effects are attributed to general activation of all NR transcriptional actions. Understanding the molecular mechanisms of NR transcriptional functions is ...
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