Search for European Projects

17 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer (CAM-PAC)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from di ...
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 18

 FINISHED 

DNA Damage Response (DDR) signaling in tumor formation and therapeutic resistance of gliomas (GLIDD)

Start date: Jul 1, 2014, End date: Jun 30, 2018,

"The gliomas are a large group of brain tumors and Glioblastoma Multiforme (GBM) is the most common and lethal primary central nervous system (CNS) tumor in adults. Despite the recent advances in treatment modalities, GBM patients generally respond poorly to all therapeutic approaches and prognosis remain dismal. Standard therapy for GBMs includes resection of the tumor mass, followed by concurren ...
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 1

 FINISHED 

Bioinformatics and Integrative Genomics for a Novel Personalized Cancer Therapy (PERSMEDOMICS)

Start date: Jul 1, 2013, End date: Jun 30, 2017,

"The dawn of the age of personalized cancer treatment provides the promise to identify the right drug for the individual that will greatly improve the patient’s outcome. It is well known that cancer drugs work only in small subset of patients. For many of these agents, there are putative markers of response in the literature but very few are been used in clinical practice. More importantly, new ...
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 1

 FINISHED 

Risk, Stem Cells and Tissue Kinetics – Ionising Radiation (RISK - IR)

Start date: Nov 1, 2012, End date: Apr 30, 2017,

The magnitude of cancer risk in humans exposed to low radiation doses (
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 16

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A European Platform for Translational Cancer Research (EUROCANPLATFORM)

Start date: Jan 1, 2011, End date: Dec 31, 2016,

Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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 29

 FINISHED 

Joint training and research network on Chromatin Dynamics and the DNA Damage Response (ADDRESS)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

DNA is tightly wrapped around histones to form chromatin, a highly dynamic structure that can adopt different conformations with contrasting degrees of compaction. Essential processes of DNA metabolism, such as DNA repair, replication or transcription operate in the context of chromatin and higher order chromosomal organization. Understanding how modulation of chromatin structure and repair influe ...
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 10

 FINISHED 

Systems Biology of Mitosis (MitoSys)

Start date: Jun 1, 2010, End date: May 31, 2015,

"MitoSys will generate a comprehensive mathematical understanding of mitotic division in human cells, a process of fundamental importance for human health. To create the critical mass and multidisciplinarity that is needed to achieve this ambitious goal, internationally leading mathematicians, biochemists/biophysicists and biologists working at twelve universities, research institutes, internation ...
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 14

 FINISHED 

Improving the selectivity of kinase inhibitors: Characterizing binding mechanisms of inhibitors targeting inactive states and allosteric sites (KIBinding)

Start date: Mar 1, 2013, End date: Feb 28, 2015,

Kinase proteins are key to signaling in eukaryotic cells, so it is not surprising that their dysfunction has been implicated in human diseases such as cancer and inflammatory disorders. As a result, kinases have become important targets for drug discovery. The majority of kinase inhibitors bind to the ATP-binding site, which is highly conserved among the different kinases. In order to increase ...
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 2

 FINISHED 

Development of novel diagnostic and therapeutic approaches to improve patient outcome in lung and pancreatic tumours (CANCERALIA)

Start date: Apr 1, 2011, End date: Sep 30, 2014,

Lung and pancreatic cancers still have a mortality rate over 85% at 5 years of diagnosis, a clear demonstration of the actual treatment failure and the need for improved clinical management. This involves better tools for diagnosis, prognosis, and selection of sensitive and resistant patients to current conventional therapies or improved innovative treatments as well as the development of novel th ...
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 8

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Role of the protein kinase Mastl in Cell Division and Cancer (Mastl CDC)

Start date: Sep 1, 2012, End date: Aug 31, 2014,

The cell division cycle is an essential step in living organisms. Different studies have led to a model where cell cycle kinases act as major engines to promote cell cycle progression throughout the different phases of the cell cycle. In addition to Cyclin- dependent kinases (Cdks), Polo-like and Aurora kinases, other kinases have recently emerged as important regulators of cell cycle progression. ...
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 1

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Rational designing of new meganucleases as molecular scissors for genomic tailoring (SMARTBREAKER)

Start date: Jul 1, 2011, End date: Jun 30, 2014,

"Regenerative medicine using gene targeting by homologous recombination is one of the most powerful methods to achieve precise genome modifications. In the absence of double strand breaks the frequency of homologues recombination events at a target site is very low. A wide range of molecular tools are used to achieve targeting double strand breaks to increase the efficiency of homologues recombina ...
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 1

 FINISHED 

Genome Maintenance in the Context of Chromatin (CHROMOREPAIR)

Start date: Dec 1, 2008, End date: Nov 30, 2013,

"With the availability of the essentially complete sequence of the human genome, as well as a rapid development of massive sequencing techniques, the research efforts to understand genetics and disease from a cis standpoint will soon reach an endpoint. However, our emerging knowledge of gene regulation networks reveals that epigenetic regulation of the hereditary information plays crucial roles in ...
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 1

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Nucleosome Structure & Function across Biological Scales and Biological Function (NUCLEOSOME4D)

Start date: Nov 1, 2009, End date: Oct 31, 2013,

Chromatin packages a few meters of DNA into a nucleus measuring a few microns. This tight folding occurs by assembling DNA with histones into so-called nucleosomes, thus ensuring the mechanical stability of our genome. On the flipside, this makes nucleosomes a formidable obstacle to the machines that read, copy or repair its DNA message. One of the fundamental questions in biology is to understand ...
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 17

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ROLE OF HISTONE MODIFICATIONS IN DNA DAMAGE RESPONSE IN MAMMALS (HISTONEDDR)

Start date: Dec 1, 2009, End date: Oct 1, 2013,

"After DNA damage a signal must be created to recruit DNA repair factors to the lesion. Then the repair machinery needs to gain access to DNA and chromatin should be properly reassembled. DNA assembly with histones to form chromatin creates a physically limits the access to DNA. Alterations of chromatin that do not affect the DNA sequence constitute the epigenetic level of regulation of DNA metabo ...
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 1

 FINISHED 

Clonal analysis in pancreatic development, differentiation and carcinogenesis (PanClon)

Start date: Oct 1, 2011, End date: Sep 30, 2013,

The knowledge about pancreas development and the establishment of pancreatic cell lineages has exploded in recent years. These studies are important in developing strategies for regenerative medicine. On the other hand, pancreatic ductal adenocarcinoma (PDAC) is the tumor with the worst prognosis in humans: its incidence rate is equivalent to its mortality rate, with a median survival of less than ...
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 1

 FINISHED 

Safer gene repair and targeting based on the monomeric meganuclease I-DmoI by design of homologous-recombination-inducing nickase activity (DmoNickaseDesign)

Start date: Apr 1, 2011, End date: Mar 31, 2013,

An important aspect of cancer therapy is the specificity of the treatment. Significant progress has been made in drug design. However, gene therapy by direct targeting of oncogenes has not yet met equal success. Among the most valuable tools are meganucleases, also known as homing endonucleases (HE). These enzymes recognize and cleave long (around 20bp) DNA sequences and have been shown to induce ...
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 1

 FINISHED 

The role of activation-induced cytidine deaminase in inflammation-induced carcinogenesis (InflAIDCan)

Start date: Mar 1, 2010, End date: Aug 31, 2011,

Activation-induced cytidine deaminase (AID) is a DNA-modifying enzyme essential for somatic hypermutation and class switch recombination in B cells. However, deregulation of AID can induce mutations and chromosomal translocations in B cells thus promoting neoplastic transformation and cancer development. AID expression is controlled by several transcription factors like those of the Rel/NF-kappa B ...
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 1