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The role of histone variant macroH2A in Epigenetics (RHVME)

Start date: Jun 1, 2008, End date: May 31, 2010,

The histone variant macroH2A1 (mH2A1) is associated with gene repression but the molecular mechanisms by which it exerts its function are largely unknown. mH2A is recruited to the IL-8 promoter by ATF-2 where it functions as a transcriptional repressor. Interestingly, macroH2A1 has been shown to bind O-acetyl-ADP-ribose (OAADPR).The functional consequences of this interaction are unknown. This pro ...
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