3 European Projects Found
Searched on 125080 European Projects
FINISHED
PROBING THE ROLE OF SODIUM CHANNELS IN PAINFUL NEUROPATHIES (PROPANE STUDY)
Start date: Oct 1, 2013, End date: Sep 30, 2016,
Neuropathic pain is a frequent feature of peripheral neuropathy adversely impacting patients’ quality of life and increasing health care costs. Not all individuals with neuropathy develop pain and it is not possible to predict who is more or less susceptible among those with similar risk exposure. Inability to identify high-risk individuals and drug-responder patients and lack of drugs acting on t ...
Read Project
9
Partners Participants
FINISHED
Role of Adipose DPP4 Deletion in Diet-Induced Obesity (ADDIO)
Start date: Jul 1, 2013, End date: Jun 30, 2015,
"Dipeptidyl peptidase-4 (DPP-4) is an exoprotease that cleaves N-terminal dipeptides from several substrates such as glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GLP), impairing the function of the incretin system, which is of key importance for glucose homeostasis. Indeed, DPP4 inhibitors are currently in clinical use for type 2 diabetes. The host group has described for th ...
Read Project
1
Partner Participant
FINISHED
Adipokines as Drug Targets to Combat Adverse Effects of Excess Adipose Tissue (ADAPT)
Start date: Feb 1, 2008, End date: Jan 31, 2012,
"Obesity represents the major risk factor for the cardiometabolic syndrome, which is an epidemic disease that generates a severe global socio-economic burden for the public health systems. Enhanced production of proinflammatory adipocytokines by expanded adipose tissue is now considered as a key event in the pathogenesis of this syndrome. This process involves i) the systemic release of adipokines ...
Read Project
