Search for European Projects

17 European Projects Found

Searched on 125080 European Projects

 FINISHED 

A Phase Ib/II study of MEK1/2 inhibitor PD-0325901 or MEK-162 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients (MERCURIC)

Start date: Dec 1, 2013, End date: Nov 30, 2020,

Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omi ...
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 13

 FINISHED 

Advanced Radiotherapy, Generated by Exploiting Nanoprocesses and Technologies (ARGENT)

Start date: Mar 1, 2014, End date: Feb 28, 2018,

Cancer, the second most common form of death after cardiovascular disease, is a major European health concern. In 2006, 3.1 million new cases were diagnosed and 1.7 million deaths were attributed to cancer within Europe. The European Commission has a “European Partnership for Action against Cancer” (IP/09/1380) with the aim of reducing the number of cancer cases by 15% by 2020. A key challenge is ...
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 10

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Understanding Klebsiella pneumoniae respiratory infections (U-KARE)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

"Pneumonia is leading cause of death from infection. During infection, microbial presence is monitored by receptors recognizing evolutionary conserved structures. Pathogen recognition is associated with the activation of few regulators and signaling pathways controlling host defence systems. A better understanding of the host-pathogen interaction offers the potential for pharmacological interventi ...
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 1

 FINISHED 

Cystic Fibrosis Microbiome-determined Antibiotic Therapy Trial in Exacerbations: Results Stratified (CFMATTERS)

Start date: Oct 1, 2013, End date: Jun 30, 2017,

Antimicrobial resistance is arguably the most significant challenge facing the EU health care system. The unnecessary use of antibiotics is a key driver in the development of antibiotic resistance. Cystic Fibrosis (CF) represents a unique disease model to study bacterial resistance and to explore therapeutic strategies for same, as chronic lung infection overlaps with acute lung exacerbations caus ...
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 15

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Improving the organisation of maternal health service delivery, and optimising childbirth, by increasing vaginal birth after caesarean section (VBAC) through enhanced women-centred care (OPTIBIRTH)

Start date: Sep 1, 2012, End date: Feb 28, 2017,

Optimal, healthy pregnancy followed by normal birth is the ideal. Caesarean section (CS) doubles the risk of mortality and morbidity (hysterectomy, blood transfusion), and increases the risk of postnatal infection by 5, compared with vaginal birth (WHO Global Survey on Maternal and Perinatal Health). The European Perinatal Health Report (2008) notes “widespread concern” over rising CS rates, which ...
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 11

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Infection biology training network: shaping the future of infectious diseases treatments (INBIONET)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

"The increasing number of bacteria resistant to all antibiotics and antimicrobials and the virtual lack of antiviral drugs make necessary to develop therapeutics based on new targets/approaches. European-wide-acting sectors must permanently improve their capabilities and capacities to cope with these challenges. Thus, the demand for experts trained to understand infectious diseases in their whole ...
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 11

 FINISHED 

Repair of Diabetic Damage by Stromal Cell Administration (REDDSTAR)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

50 million diabetic EU citizens are using approved anti-diabetic agents to control their glycaemia. However, suboptimal glycemic control leads to 6 progressive diabetic complications, namely: nephropathy, retinopathy, cardiomyopathy, neuropathy and foot ulceration. In 2010, 11% of EU adult deaths (634,000) were caused by diabetic complications. These distinct disorders have few effective medicines ...
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 10

 FINISHED 

Biomarker for Cardiovascular Risk Assessment in Europe (BiomarCaRE)

Start date: Oct 1, 2011, End date: Mar 31, 2016,

Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role in the drive towards personalised medicine remains uncertain.Based on harmonised and standardised European population cohorts we have built significant research collabo ...
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 31

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Reproductive Biology Early Research Training (REPRO-TRAIN)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

The “Reproductive Biology Early Research Training” network (REPRO-TRAIN) aims to provide all the elements required to train the nextgeneration of researchers with the latest skills to solve the current societal problems in male reproductive biology (Andrology). Thedecline in sperm counts and concomitant increase in testicular cancer demands research in this field as an urgent priority.Spermatogene ...
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 8

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Fast-Tracking Pathology via Automated Image Analysis and High-Performance Computing: Application to Prostate Cancer Diagnostics (FAST-PATH)

Start date: Nov 1, 2011, End date: Oct 31, 2015,

Histopathology has traditionally been a low-throughput, labour-intensive technique. Conventional manual annotation of tissue slides requires a pathologist to examine the tissue and cellular components to grade the level of disease progression. However, digital pathology and automated digital image analysis solutions can provide a more rapid solution. In recent years, there has been a rapid uptake ...
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 6

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Non-genetic mechanisms of intrinsic antimicrobial resistance (NONANTIRES)

Start date: Aug 1, 2013, End date: Jul 31, 2015,

NONANTIRES is a groundbreaking project to discover alternative ways for controlling the problem of infection treatment failures due to multidrug antimicrobial resistance. Specifically, my efforts will focus on Gram-negative bacterial opportunistic pathogens that exhibit pan-antibiotic, intrinsic resistance. My team has recently uncovered a novel resistance mechanism based on a cooperative behaviou ...
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 1

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Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES)

Start date: Feb 1, 2010, End date: Jan 31, 2015,

CHANCES aims at combining and integrating on-going cohort studies in order to produce evidence on ageing-related health characteristics and determinants in Europe, and their socio-economic implications. 15 cohorts participate, covering populations from 18 EU Member States, 4 associate countries, and 3 additional countries. The combination of these different studies would lead to an integrated appr ...
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 17

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The COMET (Core Outcome Measures in Effectiveness Trials) Initiative (COMET)

Start date: Oct 1, 2012, End date: Dec 31, 2014,

"Clinical trialists often struggle when trying to choose the outcomes to measure which would be of most use to the patients, practitioners and policy makers who will use their research to help them make decisions. These difficulties are passed on to those producing and reading systematic reviews, many of whom have experienced the frustration of finding that the original researchers either did not ...
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 11

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Apoptosis Modelling for Treatment Decisions in Colorectal Cancer (APO-DECIDE)

Start date: Nov 1, 2012, End date: Oct 31, 2014,

"With the arrival of new colorectal cancer (CRC) therapeutics targeting specific cell signalling pathways, such as anti-EGFR therapy, personalised cancer treatment is at the door step of clinical practise. This progress in drug development contrasts strikingly with current clinical practice, where decision making depends largely on clinical factors such as tumour staging and age of patient, with t ...
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 7

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EUROpean consortium on NEUTralising antibodies using gp41 (EURONEUT-41)

Start date: Jan 1, 2008, End date: Mar 31, 2014,

There is now an increasingly solid body of scientific evidence which demonstrates that the binding of small molecular weight compounds, peptides and antibodies (Abs) to fusion-intermediate conformations of gp41 leads to an inhibition of HIV cell entry. The principal aim of this project is to exploit this information by establishing a platform where gp41-derived vaccine candidates will be designed ...
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 19

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European Network for Genetic and Genomic Epidemiology (ENGAGE)

Start date: Jan 1, 2008, End date: Dec 31, 2012,

"ENGAGE (European Network for Genetic and Genomic Epidemiology) has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a sub ...
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 26

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The mechanisms of cardiovascular risks after low radiation doses (CARDIORISK)

Start date: Feb 1, 2008, End date: Jun 30, 2011,

"Recent epidemiologic evidence suggests that moderate and low radiation doses to the heart may result in a moderate, but significant increase in cardiovascular mortality. So far, the pathogenesis of radiation induced heart disease has not been studied in detail. Pathohistologic studies suggest that microvascular damage plays a crucial role in the development of radiation induced cardiovascular dis ...
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