Search for European Projects

35 European Projects Found

Searched on 125080 European Projects

 FINISHED 

"Understanding the determinants of suicidal behaviour, serious accidents and violence in young people" (SAVYP)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"Direct comparisons of risk factor profiles for different forms of self-destructive, hazardous and violent behaviour in young people have rarely been made in the same study cohort. This maintains a possibly erroneous assumption that these behaviours have distinct aetiologies. These outcomes may represent different aspects of the same complex underlying aetiology, rather than being disjunctive phen ...
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 2

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Life in a cold climate: the adaptation of cereals to new environments and the establishment of agriculture in Europe (ADAPT)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"This project explores the concept of agricultural spread as analogous to enforced climate change and asks how cereals adapted to new environments when agriculture was introduced into Europe. Archaeologists have long recognized that the ecological pressures placed on crops would have had an impact on the spread and subsequent development of agriculture, but previously there has been no means of di ...
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 5

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Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors (REQUITE)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

Long-term side-effects of radiotherapy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million ...
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 15

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A “Universal” Influenza Vaccine through Synthetic, Dendritic Cell-Targeted, Self-Replicating RNA Vaccines (UniVax)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

Although vaccination is the cornerstone of prophylaxis, current vaccines provide only moderate protection. Most employ inactivated or protein-based, including multimeric antigen, vaccines requiring annual updating. Their limited antigen loads provide limited capacity for inducing robust immune defences, without assurance that both humoral and cell mediated (CMI) responses, as well as durable immun ...
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 11

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Health and Environment-wide Associations based on Large population Surveys (HEALS)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

Assessing individual exposure to environmental stressors and predicting health outcomes implies that both environmental exposures and epi/genetic variations are reliably measured simultaneously. HEALS (Health and Environment-wide Associations based on Large population Surveys) brings together in an innovative approach a comprehensive array of novel technologies, data analysis and modeling tools th ...
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 37

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Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth char ...
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 19

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EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma (EEC)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES o ...
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 21

 FINISHED 

Definition and characterization of type I interferonopathies (T1-IFN)

Start date: Mar 1, 2013, End date: Feb 28, 2018,

"Although the concept of grouping Mendelian disorders associated with an up-regulation of type I interferon (IFN) has not been previously recognised in the medical literature, my past and current work argues that this concept has scientific validity and clinical utility. I believe that such conditions, which include Aicardi-Goutières syndrome (AGS), spondyloenchondrodysplasia, and some cases of sy ...
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 2

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Genetic High Throughput Screenings by random mutagenesis to identify Plasmodium falciparum critical genes for asexual growth, sexual differentiation and virulence affecting host immune responses (GeneticHTS reveal Pf)

Start date: Feb 1, 2011, End date: Feb 21, 2018,

Malaria is a global health problem that demands immediate practical actions to contain the high infection and mortality rates caused by Plasmodium species. Protective vaccine is still missing. Available drugs diminish their impact against Plasmodium as resistances are rising and expanding on the territories. While no vaccine of the current portfolio showed ideal protection and low-cost feasibility ...
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 2

 FINISHED 

Pluripotent stem cell resources for mesodermal medicine (PLURIMES)

Start date: Feb 1, 2014, End date: Jan 31, 2018,

Harnessing the capacity of pluripotent stem cells (PSCs) to produce functional cell types with precision and at scale will enable new treatment modalities for degenerative diseases. A major target for such therapies is mesodermal tissue, muscle, bone and cartilage. The goal of PluriMes is to create a bioengineering platform for directing PSCs into specific classes of mesodermal/mesenchymal progeni ...
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 12

 FINISHED 

MAGnetic Innovation in Catalysis (MAGIC)

Start date: Feb 1, 2014, End date: Jan 31, 2018,

"The aim of the MAGIC Innovative Doctoral Programme is to train the future generation of leading investigators of biological catalysis/enzymology with a view to developing new enabling technologies that can advance physical understanding of catalysis and mechanism. Recent research has shown that enzyme catalysts exploit the coupling of motions to the reaction coordinate and employ classical and qu ...
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 1

 FINISHED 

Systems medicine of chronic inflammatory bowel disease (SYSMEDIBD)

Start date: Dec 1, 2012, End date: Nov 30, 2017,

Inflammatory bowel disease (IBD) is a major health problem with severe co-morbidities, requiring life-long treatment. Oscillating processes, like biological clocks are well studied and modeled in a number of systems. Circadian rhythms are extremely important for optimal treatments of patients. Recently, the NfkB pathway has been shown to be oscillating. In this project, we will model NfkB oscillat ...
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 13

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The biogenesis of tail-anchored membrane proteins: knowledge and exploitation (TAMPTING)

Start date: Nov 1, 2013, End date: Oct 31, 2017,

Even in the simplest cells, the integration of proteins into a biological membrane is a complex process that is frequently coupled to ribosomal protein synthesis, and requires the coordinated actions of several additional cellular machines. The de novo recapitulation of such a complex process is well beyond the scope of our current technical abilities. Indeed, the techniques that are used to creat ...
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 8

 FINISHED 

Bedside monitoring of infection based on exhaled breath (BreathDx)

Start date: Nov 1, 2013, End date: Oct 31, 2017,

Molecular analysis of exhaled breath is a new frontier in medical testing with an enormous potential for monitoring respiratory disease.Breath tests are non-invasive and require minimal patient effort. This makes them applicable in a wide range of settings varying from theintensive care unit (ICU) to home. Respiratory infections are the primary cause of death in ICU. More than half of the patients ...
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 4

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Methods for Integrated analysis of Multiple Omics datasets (MIMOmics)

Start date: Oct 1, 2012, End date: Sep 30, 2017,

MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with nove ...
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 15

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Sensing and integration of signals governing cell polarity and tropism in fungi (FUNGIBRAIN)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

"Cell polarity and directed growth (tropism) are fundamental biological processes. Most fungi are dependent on these processes because they grow as polarised filaments called hyphae, whose growth and developmentare governed by physical and chemical cues from the environment. Such cues include surface-contact, light, nutrients, mating partners, host organisms, or ‘self’ hyphae from within the fung ...
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 13

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Human pluripotent stem cell differentiation, safety and preparation for therapeutic transplantation in Huntington’s disease (Repair-HD)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

This project will tackle the huge complexity of taking stem cell therapies to clinical application for neurodegenerative disease by focusing on selective differentiation of a single neuronal phenotype (medium spiny striatal neuron: MSN) for a single well-defined disease (Huntington’s: HD). Our consortium contains expertise in all elements required to drive this technology to the point of clinical ...
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 10

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Innovative, mechanistic-based strategies for delivery of therapeutic macromolecules across cellular and biological barriers (PathChooser)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

Nanomedicine offers capability to significantly change the course of treatment for life-threatening diseases. Many of the most significant current therapeutic targets, to be viable in practice, require the efficient crossing of at least one biological barrier. However, the efficient and controlled crossing of the undamaged barrier is difficult. The range of small molecules that can successfully do ...
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 9

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The impact of chromosomal instability on health: Molecular causes and consequences of aneuploidy (PLOIDYNET)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than s ...
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 14

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Aging Eye (AGEYE)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

"AGEYE is a coherent training and career development platform for the training and career development of 12 young researchers in Vision Sciences. It aims to structure the collaboration in research and training between 5 leading academic centres in Europe, bringing together a new combination of in-depth expertise from 4 countries. Furthermore, to strengthen the contact with the industrial world, th ...
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 7

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Biological Foundation for the Safety Classification of Engineered Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of ENM with Living Organisms and the Environment (NANOSOLUTIONS)

Start date: Apr 1, 2013, End date: Mar 31, 2017,

The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced a ...
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 40

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Integrated Approaches to Food Allergen and Allergy Risk Management (IFAAM)

Start date: Mar 1, 2013, End date: Feb 28, 2017,

Up to 20 million European citizens suffer from food allergy. However management of both food allergy (by patients and health practitioners) and allergens (by industry) is thwarted by lack of evidence to either prevent food allergy developing or protect adequately those who are already allergic. iFAAM will develop evidence-based approaches and tools for MANAGEMENT of ALLERGENS in FOOD and integrate ...
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 46

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Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)

Start date: Mar 1, 2012, End date: Feb 28, 2017,

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:(i) to identify novel mechanisms ...
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 32

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Progression factors in melanoma leading to novel therapeutic targets (PROMINENT)

Start date: Feb 1, 2012, End date: Jan 31, 2017,

"Presently, there is little hope of cure for patients with metastatic melanoma. Greater insight into the molecular and cellular biology of melanoma and the immune response mounted against it is required to indicate new therapeutic approaches. We have created zebrafish models for analyzing melanoma initiation and progression. Using whole genome transcriptome profiling, we have identified a number o ...
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 1

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Incorporating real-life clinical data into drug development (GETREAL)

Start date: Oct 1, 2013, End date: Dec 31, 2016,

When a new medicine reaches the market, it is accompanied by an extensive data package that provides information about the safety and efficacy of the medicine in a clinical trial setting. However, assessing the expected future value of the medicines when used in “real world” clinical practice requires additional information next to traditional (pre-authorisation) clinical trials. Regulatory, HTA ...
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 32

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Rational Bioactive Materials Design for Tissue Regeneration (BIODESIGN)

Start date: Jan 1, 2012, End date: Dec 31, 2016,

The development of functional materials for tissue regeneration is today mostly based on perceived and limited design criteria often using a single point approach with lengthy animal trials. The outcome after in-vitro and in-vivo evaluation is often disappointing resulting in a tedious iteration process. The main objective of this project is to achieve radical innovations in state-of-the-art bioma ...
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 21

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Supporting Postgraduate Research with Internships in industry and Training Excellence (SPRITE)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

SPRITE is a multi-disciplinary European training network which brings together Europe’s premier research institutes in technology and applications of ion beams. Those involved are already actively collaborating, for example in the recently very favourably reviewed EC Infrastructure project SPIRIT.SPRITE addresses the urgent European need - identified in a recent Foresight Review - to train the ne ...
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 13

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PROBING THE ROLE OF SODIUM CHANNELS IN PAINFUL NEUROPATHIES (PROPANE STUDY)

Start date: Oct 1, 2013, End date: Sep 30, 2016,

Neuropathic pain is a frequent feature of peripheral neuropathy adversely impacting patients’ quality of life and increasing health care costs. Not all individuals with neuropathy develop pain and it is not possible to predict who is more or less susceptible among those with similar risk exposure. Inability to identify high-risk individuals and drug-responder patients and lack of drugs acting on t ...
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 9

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Early Acquisition of Argument Structure (EAAS)

Start date: Aug 12, 2014, End date: Aug 11, 2016,

"The planned research will investigate the early acquisition of argument structure, a crucial example of syntax-semantics linking, in Estonian and cross-linguistic comparison. The project investigates 2 to 5-year-old children’s ability to use information from different cues signalling argument structure, namely word order, case marking, and the discourse context. The rich inflectional system and f ...
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 1

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Nanocapsules for targeted delivery of radioactivity (RADDEL)

Start date: Feb 1, 2012, End date: Jan 31, 2016,

The consortium RADDEL (RADioactivity DELivery) has a research-based approach for the training of the new generation of scientists in the development of novel functional nanomaterials . A well structured training program will be provided with a balanced combination of local and network-wide training through secondments, joint network meetings, workshops, schools, industrial training and the final n ...
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 10

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Management of Resistance to Tyrosine Kinase Inhibitors with Advanced Nanosystems (NANORESISTANCE)

Start date: Nov 1, 2011, End date: Oct 31, 2015,

NANORESISTANCE introduces for the first time (i) receptor -independent targeting of Epidermal Growth Factor Receptor-kinase activity, (ii) nuclear delivery of anti-Epidermal Growth Factor Receptor therapy with novel grafting techniques and (iii) the deciphering of resistance and lack of responsiveness to anti-EGFR therapies in the preclinical setting with mathematical models of interstitial biodi ...
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 7

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Multicentre Preclinical Animal Research Team (Multi-PART)

Start date: Sep 1, 2013, End date: Aug 31, 2015,

Millions of Europeans still suffer the consequences of neurological disease, but the number of new drugs coming to market continues to fall. Reasons for the failure of stroke drug efficacy to translate from animals to clinical trials is probably best studied, but the problem is widespread. The economic and social costs of translational failure are substantial; a new approach to translational medic ...
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 12

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Introducing diagnostic applications of ‘3Gb-testing’ in human genetics (3GB-TEST)

Start date: Sep 1, 2013, End date: Aug 31, 2015,

The landscape of genetic testing is rapidly changing. Soon, whole genome sequence analysis (3Gb-testing) will be an effective and financially viable alternative to targeted gene analysis. New technologies that allow efficient sequencing of a whole human genome in a diagnostic setting will have an enormous impact on diagnostic centres replacing many existing molecular and cytogenetic tests.Patients ...
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 11

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CAPER in Invasive Breast Cancer (CAPER/BREAST CANCE)

Start date: Jan 1, 2010, End date: Dec 31, 2014,

"Breast cancer is a major cause of death in the United States and the Western World. Advanced medical technologies and therapeutic strategies are necessary for the successful detection, diagnosis, and treatment of breast cancer. Here, we propose to use novel technologies (tissue microarrays (TMA) and automated quantivative bioimaging (AQUA)) to identify new therapeutic and prognostic markers for h ...
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 1

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Novel strategies for the cell therapy of muscular dystrophies (Stem cells for DMD)

Start date: Mar 1, 2009, End date: Feb 28, 2014,

This project aims to develop an effective cell therapy for Duchenne Muscular Dystrophy (DMD). To reach this goal we plan to transfer a human artificial chromosome containing the whole dystrophin locus into dystrophic mesoangioblasts. As the transfer is inefficient and requires selection, it is impossible to use primary cells that would undergo senescence during selection. Therefore we need to rev ...
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 3