4 European Projects Found
Searched on 125080 European Projects
FINISHED
Systems Biology of Colorectal Cancer (SYSCOL)
Start date: Jan 1, 2011, End date: Dec 31, 2015,
Colorectal cancer (CRC) is one of the most common cancers in both males and females, and it is perhaps the best understood of all epithelial tumors in terms of its molecular origin. Yet, despite large amount of work that has concentrated on understanding of colon tumorigenesis, we still do not know the full complement of molecular lesions that are individually necessary – and together sufficient – ...
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Modelling and predicting sensitivity to targeted therapies in colorectal cancers (COLTHERES)
Start date: Jan 1, 2011, End date: Dec 31, 2014,
Effective and long term treatment of cancer is now in sight, but will ultimately require an increasingly ‘personalised’ approach where the ‘right’ combination of drugs will be administered to the ‘right’ patients, based on a detailed understanding of their genetic background and their co-associated sensitivity or resistance ‘biomarkers’. Efforts are specifically required to identify validated risk ...
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11
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Genomic predictors and oncogenic drivers in hepatocellular carcinoma (HEPTROMIC)
Start date: Nov 1, 2010, End date: Apr 30, 2014,
"Hepatocellular carcinoma (HCC) accounts for more than 90% of liver cancers, and is a major health problem. Its incidence is growing and with more than 700,000 annual cases worldwide -50,000 in Europe-, it is the 3rd cause of cancer-related mortality. Most patients are diagnosed at advanced stages with dismal survival rates lower than 1 year, even after sorafenib, the sole systemic therapy availab ...
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10
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Role of Class IIa Histone deacetylases in hematopoietic cell differentiation (HDAC hematopoiesis)
Start date: Sep 1, 2007, End date: Aug 31, 2011,
Chromatin, the higher order structure of DNA and protein, forms a barrier for gene transcription. Modification of histones, a major component of the chromatin, is a critical mechanism by which the barrier is regulated. An important modification, which is thought to activate transcription, is the acetylation of histones. Regulation of histones acetylation is performed by the antagonistic activiti ...
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