2 European Projects Found
Searched on 125080 European Projects
FINISHED
Enzymatic and genomic targets of histone modifying enzymes and their role in liver metabolism and hepatocarcinogenesis (SET-NET)
Start date: Jan 1, 2012, End date: Dec 31, 2016,
"In this proposal we will study the role of histone methytransferases Set9, PR-SET7, Smyd2, Smyd3 and the demethylase LSD1 in hepatocarcinogenesis and in the regulation of hepatic metabolic pathways.The hypothesis raised here suggests that the function of histone modifying enzymes is realized through 4 overlapping regulatory layers: i. via modifications of chromatin, ii. via modifications of recen ...
Read Project
1
Partner Participant
FINISHED
Nuclear HuR-hnRNP interactions in post-transcriptional regulation of inflammatory gene expression (nRNPs & inflammation)
Start date: Dec 1, 2011, End date: Nov 30, 2013,
Inflammation, essential component of the innate immune response, allows multicellular organisms to repair damaged tissue. Excessive inflammation however, can itself exacerbate tissue damage, leading to chronic inflammation-related disease. The expression of crucial mediators of the inflammatory response is tightly regulated at transcriptional and post-transcriptional levels. Recent studies have sh ...
Read Project
