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Over 40 European Projects Found

Searched on 125080 European Projects

 FINISHED 

An integrated interdisciplinary approach to animal-free chemical and nanomaterial safety assessment (in3)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro a ...
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 14

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Harnessing the power of enzymatic oxygen activation (OXYTRAIN)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

...rious metabolic routes. The chemistry feasible with these biocatalysts is unrivalled when compared with conventional chemical methods. Therefore, these oxygenating enzymes are very promising tools in biotechnological approaches. However, when compared with other enzyme classes, such as hydrolases, oxygenases are still in their infancy considering their biotechnological potential. To fully exploit ...
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 10

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Synthetic bacterial lipid rafts to optimize industrial bioprocesses (Rafts4Biotech)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Genetic tractability of bacterial cells allows generating synthetic microbial chassis platforms (SMCPs) with remarkable biotechnological applications but their functionality currently faces important off-genome limitations due to deficient protein-protein interactions, unfavorable protein stoichiometry or generation of toxic intermediates that ultimately compromise the industrial production proces ...
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 13

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Sustainable Algae Biorefinery for Agriculture aNd Aquaculture (SABANA)

Start date: Dec 1, 2016, End date: Nov 30, 2020,

SABANA aims at developing a large-scale integrated microalgae-based biorefinery for the production of biostimulants, biopesticides and feed additives, in addition to biofertilizers and aquafeed, using only marine water and nutrients from wastewaters (sewage, centrate and pig manure). The objective is to achieve a zero-waste process at a demonstration scales up to 5 ha sustainable both environmenta ...
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 11

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Valorisation of mushroom agrowastes to obtain high value products (FUNGUSCHAIN)

Start date: Nov 1, 2016, End date: Oct 31, 2020,

The project aims at the valorization of agricultural residues coming from mushroom (Agaricus Bisporus) farming residues as a case to set up new cascading possibilities using innovative procedures to extract high value bio-based additives (antioxidants, antimicrobials, proteins), convert lipids into bioplasticizers and polysaccharides (glucans and fermentable sugars) into biopolymers using remainin ...
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 17

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Predictive and Accelerated Metabolic Engineering Network (PAcMEN)

Start date: Oct 1, 2016, End date: Sep 30, 2020,

The world economy is dependent on fossil resources: oil, gas and coal. The fossil resources are finite and their consumption causes catastrophic environmental changes. Therefore we need to move towards sustainable economy using renewable resources for energy and chemicals production. Via metabolic engineering approach, novel microbial cells can be created that can convert biomass and waste into fu ...
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 7

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A multidisciplinary approach to cell division: From human oocyte to synthetic biology (DivIDe)

Start date: Apr 1, 2016, End date: Mar 31, 2020,

The cell is the universal unit of living matter, and there cannot be propagation of life without cell division. DivIDe aims to investigate the mechanisms and principles of cell division and to reproduce them in vitro with synthetic approaches. Crucial to cell division is the mitotic spindle, a structure whose main duty is the separation of chromosomes. The spindle is made of microtubules (MT), mol ...
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 9

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Mastiha treatment for healthy obese with NAFLD diagnosis (MAST4HEALTH). (MAST4HEALTH)

Start date: Mar 1, 2016, End date: Feb 29, 2020,

MAST4HEALTH is set on the concept of a multidisciplinary approach to assess a non-pharmacological intervention for managing NAFLD/NASH, one of the most common complications of obesity and diabetes mellitus in Western populations affecting approximately 50% of diabetics and 76% of obese patients. Because of limitations in current NAFLD treatment therapies, many new efforts focus on exploring non-ph ...
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 13

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Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes (T2DSystems)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

Type 2 diabetes (T2D) is a major public health problem, affecting 55 million European citizens. T2D ensues in individuals who develop a progressive pancreatic beta cell failure. T2D probably comprises a heterogeneous group of diseases. A new molecular taxonomy of T2D is essential for the development of medical care that is predictive, preventive and personalized. Currently available T2D therapies ...
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 12

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Accelerated Early staGe drug diScovery (AEGIS)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

The development of effective novel drugs - especially for rare and neglected diseases - is one of the biggest challenges of the upcoming decades, as illustrated by the recent Ebola outbreak. Moreover, European innovation in new drug registrations is dramatically falling behind compared to the US and Asia.The principal aim of the AEGIS ITN is to implement the first comprehensive, intersectoral cros ...
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 11

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European Prevention of Alzheimer’s Dementia Consortium (EPAD)

Start date: Jan 1, 2015, End date: Dec 31, 2019,

Background:The secondary prevention of Alzheimer’s dementia (AD) is achievable if we can identify individuals at risk of disease progression defined by biomarker evidence of AD pathology and no or only minimal clinical symptoms and engage them in a standing adaptive clinical trial, of the highest quality, testing multiple interventions. To achieve this, EPAD will also provide the analytical infras ...
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 40

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From Omics to Patient: Improving Diagnostics of Pathogenic Yeasts (OPATHY)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

OPATHY is an innovative translational research training network that will explore the potential of omics technologies, including genomics, transcriptomics and proteomics, to study the interactions of yeasts that cause disease to humans (e.g. Candida and Cryptococcus sp.) with their host, and to develop new diagnostic tools to monitor yeast infections in the clinic. Today, these infections are poor ...
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 10

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Female cancer prediction using cervical omics to individualise screening and prevention (FORECEE)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

While prevention of most female specific cancers (ovarian, breast, endometrial) has not progressed substantially in recent years, significant progress has been made with cervical cancer due to accessibility of the cell of origin (cervical smear) and availability of a test for the causal agent (human papilloma virus); together these enable identification of high risk individuals and interventions t ...
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 14

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Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth char ...
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 19

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Advanced nanophotonic point-of-care analysis device for fast and early diagnosis of cardiovascular diseases (PHOCNOSIS)

Start date: Sep 1, 2015, End date: Aug 31, 2018,

The PHOCNOSIS project aims at the development and the preclinical validation of a nanotechnology-based handheld point-of-care testing (POCT) analysis device for its application in the early diagnosis of cardiovascular diseases (CVD). The diagnosis will be carried out by means of the fast (
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 10

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Targeting novel lipid pathways for treatment of cardiovascular disease (Athero-Flux)

Start date: Sep 1, 2013, End date: Aug 31, 2018,

...we hypothesize that by controlling sphingolipid metabolism a better primary and secondary prevention of CVD events than with statins alone can be achieved. Athero-Flux builds on cutting-edge SME-led biotechnological tools including: a) high-throughput lipidomic platforms that allow the study of kinetics of lipid metabolism at the molecular lipid level including the new stable isotope labelling te ...
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 12

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Gene Therapy for X-linked Chronic Granulomatous Disease (CGD) (NET4CGD)

Start date: Dec 1, 2012, End date: May 31, 2018,

This project is focused on the clinical development of a new orphan drug that can rapidly become a new treatment option for patients with the X-linked form of chronic granulomatous disease (X-CGD). This rare primary immune deficiency of phagocytes is caused by mutations in the gp91phox gene. Affected patients are highly-susceptible to infections and develop inflammatory granulomas. Several member ...
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 11

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Quod Erat Demonstrandum: Large scale demonstration for the bio-based bulk chemicals BDO and IA aiming at cost reduction and improved sustainability (BIO-QED)

Start date: Jan 1, 2014, End date: Dec 31, 2017,

...dded value chemicals and energy.Due to its extensive scope and complex character such a transition is expected to take at least 1 to 2 decades. The current starting position for Europe on the biotechnological production of added value chemicals from renewable biomass is still very good, with its leading scientific position on industrial White Biotechnology, the global top positions of the European ...
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 12

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Nanotherapeutics to Treat Antibiotic Resistant Gram-Negative Pneumonia Infections (PNEUMONP)

Start date: Jan 1, 2014, End date: Dec 31, 2017,

The main objective of PneumoNP is the development of a theragnostic system for the treatment of lung Gram-negative bacterial infections. As a proof of concept PneumoNP will focus the attention on Klebsiella pneumoniae caused infections. A diagnostic kit will be developed to enable a rapid and precise identification of the bacteria strain causing the infection and avoid the use of wide spectrum a ...
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 11

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THE MICRO ALGAE BIOREFINERY (D-FACTORY)

Start date: Dec 1, 2013, End date: Nov 30, 2017,

The D-Factory aims to set a world benchmark for a sustainable biorefinery based on biomass from halophilic microalgae. Representing the largest (100s ha) of current commercial cultivation technologies for any microalga, Dunaliella microalgal biomass production uses raceways and lakes, and will be expanded with biorefinery concepts by drawing in European innovations in key biomass processing techno ...
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 14

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Multi-product Integrated bioRefinery of Algae: from Carbon dioxide and Light Energy to high-value Specialties (MIRACLES)

Start date: Nov 1, 2013, End date: Oct 31, 2017,

Microalgae are a promising feedstock for sustainable supply of commodities and specialties for food and non-food products. Despite this potential the implementation is still limited which is mainly due to unfavourable economics. Major bottlenecks are the lack of available biomass at acceptable costs and the absence of appropriate biorefinery technologies. The 4-year MIRACLES project aims to resolv ...
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 27

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Advanced Materials for Cardiac Regeneration (AMCARE) (AMCARE)

Start date: Nov 1, 2013, End date: Oct 31, 2017,

The Advanced Materials for Cardiac Regeneration (AMCARE) consortium aims to establish a translational research program to develop truly restorative therapies for acute myocardial infarction repair (MI) by optimising cardiac progenitor cell (CPC) therapy using smart biomaterials and advanced drug delivery, and coupling these therapeutics with minimally-invasive surgical devices. Two distinct biomat ...
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 10

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Advanced Immunization Technologies (ADITEC)

Start date: Oct 1, 2011, End date: Sep 30, 2017,

...disciplinary approach in which diverse but complementary scientific disciplines and technologies converge. Therefore some of the most competitive European research groups from public institutions and biotechs have agreed to join forces in ADITEC, together with top US groups on systems biology and adjuvants to support this enterprise.A systems biology approach will be used to study licensed and exp ...
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 53

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A common European approach to the regulatory testing of nanomaterials (NANOREG)

Start date: Mar 1, 2013, End date: Feb 28, 2017,

The innovative and economic potential of Manufactured Nano Materials (MNMs) is threatened by a limited understanding of the related EHS issues. While toxicity data is continuously becoming available, the relevance to regulators is often unclear or unproven. The shrinking time to market of new MNM drives the need for urgent action by regulators. NANoREG is the first FP7 project to deliver the answe ...
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 73

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Gaining Productivity, Cost Efficiency and Sustainability in the Downstreaming Processing of Bio Products by novel Integration and Intensification strategies (Intenso)

Start date: Aug 1, 2012, End date: Jan 31, 2017,

The European Life science and chemical industries increasingly depend on effi-cient, sustainable, and cost-effective bioprocessing platforms to remain competi-tive. A critical assessment of current bottlenecks during (bio) manufacturing clearly indicates that the recovery and purification of biologicals in large scale in responsible for many inefficiencies.INTENSO proposes an evaluation of the cur ...
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 17

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Targeted Modulation of Immune-System Responses in Cell Therapies (MODICELL)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

Cell-based immunotherapies are a modern treatment approach holding promise to utilize nature’s own power to treat diseases that develop on the ground of immune system aberrations. Such diseases include cancer that develops and progresses via immune escape and on the other hand rejection of transplanted organs that need to be accepted by the immune system. Because the functions of distinct immune c ...
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 5

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Pushing the Envelope of Nuclear Magnetic Resonance Spectroscopy for Paramagnetic Systems. A Combined Experimental and Theoretical Approach (pNMR)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

A network combining 9 academic research groups and 4 collaborating industrial companies is proposed to train the next generation of PhD students and post-doctoral researchers, in developing and applying novel experimental and theoretical methods in the NMR spectroscopy of systems containing paramagnetic metals. The assembled team, with researchers distributed throughout the EU, will investigate a ...
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 12

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Optimized oxidoreductases for medium and large scale industrial biotransformations (INDOX)

Start date: Nov 1, 2013, End date: Oct 31, 2016,

The INDOX proposal on industrial oxidoreductases aims to provide relevant industrial case stories to demonstrate the efficacy of optimized biocatalysts on targeted reactions, and to establish the processes scalability, sustainability and cost-efficiency versus chemical conversion processes. The chemical industry (specialties excluded) is not yet embracing enzymatic oxidation reactions to a signifi ...
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 16

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BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry)

Start date: Nov 1, 2013, End date: Oct 31, 2016,

Plants synthesize a staggering variety of secondary metabolites, and this chemodiversity is a poorly used pool of natural molecules with bioactive properties of importance for applications in the pharma and food industries. BacHBerry focusses on phenolic compounds, a large and diverse class of plant metabolites, which are currently in the spotlight due to their claimed beneficial effects in preven ...
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 20

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Design & Engineering of Photosynthetic Communities for Industrial Cultivation (PHOTO.COMM)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

The generation of young biotechnologists is of paramount importance for Europe´s future. PHOTO.COMM will train primarily early stage researchers who have demonstrated high ambitions and talents in a unique platform based on emerging technology and science that would shape the forefront of future European biotechnology. PHOTO.COMM involves the utilization of microalgae for the conversion of carbon ...
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 11

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A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Start date: Oct 1, 2011, End date: Sep 30, 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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STRATEGY TO INHIBIT TGF-Beta IN LIVER DISEASE (IT-LIVER)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

Chronic liver diseases (CLD) and their end-stages, cirrhosis and hepatocellular carcinoma (HCC), are leading causes of morbidity and mortality worldwide with enormous socio-economic costs. Patients with liver cirrhosis are at high risk of deadly hepatic failure and over 80% of HCC develop on a cirrhotic background. HCC ranks as the 5th most common cancer and with >600,000 deaths per annum it const ...
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 12

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Prolonged inhibition of semaphorine3a pathway via a bio-degradable implant towards a better therapy for visual sensory impairments (VISION)

Start date: Sep 1, 2012, End date: Aug 31, 2016,

"The visual pathway is a component of the central nervous system (CNS) and therefore is not regenerative. Acute optic nerve injury, ischemic optic neuropathy and glaucoma are conditions that initially lead to partial blindness and eventually could lead to total blindness. Extensive neuron and retinal ganglion cells (RGC) death is evidenced in these pathologies. Semaphorin 3A (Sema3A) is a cell sec ...
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 5

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Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications (MACUMBA)

Start date: Aug 1, 2012, End date: Jul 31, 2016,

Marine microorganisms form an almost untapped resource of biotechnological potential. However, its use is hindered by the low success rate of isolation of novel microorganisms and often by poor growth efficiency. Hence, the vast majority of marine microorganisms has not been cultivated and is often considered as ‘unculturable’. MaCuMBA aims at improving the isolation rate and growth efficiency of ...
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 24

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Advanced Cell-based Therapies for the treatment of Primary ImmunoDeficiency (CELL-PID)

Start date: Nov 1, 2010, End date: Apr 30, 2016,

Primary immune deficiencies (PID) are inherited disorders of the adaptive and innate immune system marked by severe infections, autoimmunity and high risk of cancer. Treatment entails hematopoietic stem cell (HSC) transplantation from allogeneic donors, however in the absence of an HLA compatible donor, HSCT outcome is limited by delayed or suboptimal reconstitution and complications. SCID-X1 and ...
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 20

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Mucus Permeating Nanoparticulate Drug Delivery Systems (ALEXANDER)

Start date: Apr 1, 2012, End date: Mar 31, 2016,

The objective of the ALEXANDER project is the identification of novel strategies (e.g., proteolytic enzyme strategy, thiomer strategy, zeta potential changing systems, SNEDDS strategy) and the optimization of existing strategies (e.g., disulfide breaking strategy and slippery surface strategy) for the efficient transport of nanocarriers through the mucus gel layer (e.g., intestinal, nasal, ocular, ...
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 20

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Sphingolipid homeostasis: from basic biology to applications (SPHINGONET)

Start date: Feb 1, 2012, End date: Jan 31, 2016,

SPHINGONET was inspired by a common vision of its partners on the training of researchers in the field of sphingolipid homeostasis and body-wide sphingolipid signaling networks using innovative technological approaches. Dysregulation of sphingolipid balances contributes to a broad range of pathological processes, spanning neurodegeneration, asthma, autoimmune disease, insuline resistance, obesity ...
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 10

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"Generation and Evaluation of ""Next-generation"" Antibody-Toxin-Conjugates for Cancer Therapy" (MABTOX)

Start date: Oct 1, 2013, End date: Dec 31, 2015,

Therapeutic antibodies have transformed cancer therapy during the last decade, due to their high selectivity of targeting cancer cells in comparison to standard small molecule chemotherapy. Most recently, the coupling of cellular toxins to therapeutic antibodies has demonstrated an even greater efficacy in the therapy of cancer and the first, highly potent antibody drug conjugate (ADC), Adcetris®, ...
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 12

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Innovative biological products for soil pest control (INBIOSOIL)

Start date: Jul 1, 2012, End date: Dec 31, 2015,

"INBIOSOIL is a timely project that proposes novel eco-efficient environmentally friendly technologies substantially contributing to the reduced input of conventional chemical pesticides for the control of subterranean crop pests of global economic importance. This would be accomplished through the generation of new formulations of biological control agents (BCAs) based on entomopathogenic fungi ...
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 15

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BioTRANSformation of by-products from fruit and vegetable processing industry into valuable BIOproducts (TRANSBIO)

Start date: Dec 1, 2011, End date: Nov 30, 2015,

"The main aim of TRANSBIO is the implementation of an innovative cascading concept for the valorisation of sub-products from fruit and vegetable processing industry using environmental friendly biotechnological solutions like fermentation and enzyme-conversion strategies to obtain valuable bioproducts like plastics (PHB), nutraceuticals / platform chemical succinic acid and enzymes for detergent a ...
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