Search for European Projects

28 European Projects Found

Searched on 125080 European Projects

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Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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 33

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ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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 47

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Mesenchymal Cells of the Lamina Propria in Intestinal Epithelial and Immunological Homeostasis (MCs-inTEST)

Start date: Jul 1, 2014, End date: Jun 30, 2019,

Mesenchymal cells (MCs) of the intestinal lamina propria refer to a variety of cell types, most commonly intestinal myofibroblasts, fibroblasts, pericytes, and mesenchymal stromal cells, which show many similarities in terms of origin, function and molecular markers. Understanding the physiological significance of MCs in epithelial and immunological homeostasis and the pathophysiology of chronic i ...
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 1

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Chromatin Dynamics in Development and Disease (Chromatin3D)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

The cell nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins which make up a structure called chromatin. The dynamics associated with these various components are responsible for regulating physiological processes and the overall stability of the genome. The destabilization of such regulatory mechanisms that act on the ...
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 12

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Keeping gene expression in check: eliciting the role of transcription in the maintenance of genome integrity (TransArrest)

Start date: Nov 1, 2012, End date: Oct 31, 2017,

Genomic integrity is essential for accurate gene expression and epigenetic inheritance. On the other hand, a prolonged transcriptional arrest can challenge genome stability, contributing to genetic and epigenetic defects and the mechanisms of ageing and disease.Here we aim to identify the molecular mechanisms that couple transcriptional arrest to chromatin alteration and repair. We wish to explore ...
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 1

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Control of metabolic and inflammatory pathways by nuclear receptors (NR-NET)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

NR-NET is a multidisciplinary consortium, whose activities are directed towards the understanding of the role of Nuclear Receptors (NRs) and coregulators in metaflammatory disease. Metaflammation - metabolic disorders linked to chronic inflammation – is an emerging concept explaining the pathogenesis of a wide-spectrum of diseases. Since several nuclear receptors can directly sense metabolic alter ...
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 11

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Transcriptional and epigenetic control of innate-like T lymphocyte development (EpiNKT)

Start date: Aug 31, 2015, End date: Aug 30, 2017,

Invariant Natural Killer T (iNKT) cells are a heterogeneous T lymphocyte population that possess innate-like characteristics and contribute to host defense against pathogens. Due to their powerful effector properties, iNKT cells are targeted for immunotherapeutic and vaccination strategies. Their effector programs are acquired during thymic development, prior to microbial exposure, and are polariz ...
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 1

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BeTheCuRE (BTCURE)

Start date: Apr 1, 2011, End date: Mar 31, 2017,

BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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 41

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Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation (INFRAFRONTIER-I3)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

...tify mouse models for the complete disease spectrum in humansTo further develop and exploit the emerging mouse mutant resource, mouse models must be preserved and made available to the European biomedical research community. To this effect, the Infrafrontier-I3 project brings together the leading European centers for systemic phenotyping of mouse mutants and the European Mouse Mutant Archive netwo ...
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 24

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Enzymatic and genomic targets of histone modifying enzymes and their role in liver metabolism and hepatocarcinogenesis (SET-NET)

Start date: Jan 1, 2012, End date: Dec 31, 2016,

"In this proposal we will study the role of histone methytransferases Set9, PR-SET7, Smyd2, Smyd3 and the demethylase LSD1 in hepatocarcinogenesis and in the regulation of hepatic metabolic pathways.The hypothesis raised here suggests that the function of histone modifying enzymes is realized through 4 overlapping regulatory layers: i. via modifications of chromatin, ii. via modifications of recen ...
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 1

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Scaffolds for alternative delivery (SADEL)

Start date: Jan 1, 2012, End date: Dec 31, 2016,

The SME-based SADEL consortium intends to develop the first generation of oral bio-therapeutics tackling disease targets in the digestive tract, by making optimal use of the Nanofitin (Nf) protein scaffold. Nf based drugs will progress through routes not travelled by antibodies while interacting with targets not modulated by chemical compounds.Existing Nf hits against validated targets will progre ...
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 10

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Phonon-Assisted Processes for Energy Transfer and Sensing (PAPETS)

Start date: Sep 1, 2013, End date: Nov 30, 2016,

There is mounting experimental and theoretical evidence that suggests that coherent electronic and vibrational dynamics are essential to understand physiological processes. This project addresses this newly emerging frontier between biology and quantum physics by aiming to determine the role of coherent vibrational dynamics in the efficiency of energy storage in natural and artificial light harves ...
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 8

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Identification and functional and mechanistic characterization of Wnt-regulated long intergenic non-coding RNAs (WNTLINCS)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

"The canonical Wnt pathway plays a central role in stem cell maintenance, differentiation and proliferation in the adult, self-renewing intestinal epithelium. Wnt signaling activates gene expression through the induced formation of complexes between DNA-binding TCF factors and the transcriptional co-activator β-catenin. Constitutive, aberrant transcriptional activity of the TCF4/β-catenin complex, ...
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 1

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OSTEOIMMUNE - Unraveling the Interactions between the Immune System and Bone (OSTEOIMMUNE)

Start date: Jun 1, 2012, End date: May 31, 2016,

Inflammatory rheumatic diseases affect millions of European citizens causing chronic pain, disability and premature death. Curative treatments are lacking. Conventional research often focuses on one single organ system such as the bone or the immune system and. ignores interactions between organ systems. OSTEOIMMUNE is a supra-disciplinary training network that targets this gap by providing compre ...
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 12

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HEMatopoietic cell IDentity : genetic and epigenetic regulation in normal and malignant hematopoiesis (HEM_ID)

Start date: Nov 1, 2011, End date: Oct 31, 2015,

In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been ...
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 12

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Nuclear HuR-hnRNP interactions in post-transcriptional regulation of inflammatory gene expression (nRNPs & inflammation)

Start date: Dec 1, 2011, End date: Nov 30, 2013,

Inflammation, essential component of the innate immune response, allows multicellular organisms to repair damaged tissue. Excessive inflammation however, can itself exacerbate tissue damage, leading to chronic inflammation-related disease. The expression of crucial mediators of the inflammatory response is tightly regulated at transcriptional and post-transcriptional levels. Recent studies have sh ...
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 1

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Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices (Masterswitch)

Start date: Dec 1, 2008, End date: Nov 30, 2013,

Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The ...
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 20

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Chromatin diseases: from basic mechanisms to therapy (DisChrom)

Start date: Nov 1, 2009, End date: Oct 31, 2013,

The scope of this ITN is to promote research and training in the field of chromatin diseases. Chromatin diseases (CD) are genetic pathologies resulting from mutations in structural components of chromatin or in enzymes that biochemically modify chromatin, altering chromatin status and thereby causing drastic effects on gene expression. CD frequency ranges from very rare to quite common pathologies ...
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 11

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The contribution of adipose tissue gene regulation to obesity-related pathogenesis (Adipose genetics)

Start date: May 1, 2011, End date: Sep 30, 2013,

Obesity is major challenge for healthcare worldwide and is linked to increased risk for type 2 diabetes and cardiovascular disease. However not all obese individuals are equally vulnerable and it has long been appreciated that central obesity (an excess of visceral fat) comprises a major risk factor for disease. It is also well established that adipose tissue from different parts of the body displ ...
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 1

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“The International Data Coordination Centre” (I-DCC)

Start date: Jan 1, 2009, End date: Sep 30, 2013,

"The I-DCC coordination and support project responds to the topic defined by HEALTH-2007-2.1.2-6 “International activities in large-scale data gathering and systems biology”. I-DCC integrates European skills, efforts, resources, and infrastructure in an international collaborative programme to establish a European Data Coordination Centre for mouse genetic resources. Large-scale mouse mutagenesis ...
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 10

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Biology of Liver and Pancreatic Development and Disease (BOLD)

Start date: Sep 1, 2009, End date: Aug 31, 2013,

Aims: provide a cutting edge research training programme encompassing complementary approaches to the investigation of liver and pancreatic development and disease. Provide early stage researchers with a balanced mix of experience and skills in academic and industry based research. Give early stage researchers a set of transferrable skills which will improve their employment and career prospects. ...
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 12

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Understanding inflammation-associated tumorigenesis for the rational design of novel anti-cancer therapeutic strategies (INFLA-CARE)

Start date: Jan 1, 2009, End date: Jun 30, 2013,

Epidemiological and experimental evidence supports a link between chronic inflammation and cancer and indicates a role for inflammatory cells in the initiation, progression and metastasis of malignancy. The objective of the collaborative integrated project INFLA-CARE is to structure a European collective of scientific and technological excellence in the field of ‘Inflammation & Cancer’ which will ...
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 22

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Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes (INFRAFRONTIER)

Start date: Mar 1, 2008, End date: Dec 31, 2012,

...dically related Life Sciences use the mouse as a model system to understand the molecular basis of health and disease in humans (>95% similarity of genes in humans and mice). An essential task for Biomedical Sciences in the 21st century will be the functional analysis of mouse models for every gene in the mammalian genome. The major bottlenecks identified by the user community will be proper ch ...
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 29

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Deciphering the role of chromatin remodelling in DNA damage repair (ChromoRepair)

Start date: Jan 1, 2011, End date: Dec 31, 2012,

Our cells are faced with thousands of DNA lesions every day. Failure to repair such lesions can lead to genomic instability, cancer development or cell death. Repair of DNA damage, however, is complicated by the fact that genomic DNA is packaged, through histone and non-histone proteins, into a condensed structure called chromatin. Recently, an increasing interest on the impact of chromatin and th ...
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 1

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Development of sensitive methodologies for exploitation of early epigenetic marker diagnosis in major types of cancer (EpiDiaCan)

Start date: Jan 1, 2010, End date: Dec 31, 2012,

Cancer is one of the major causes of mortality. Epithelial cells become malignant after accumulating genetic mutations followed by morphological changes in the epithelium. DNA Alterations include stable genetic changes in oncogenes, tumor suppressor genes and reversible epigenetic changes. Different forms of epigenetic mechanisms have been shown to modify the expression of key genes during tumour ...
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 7

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Integrated approaches to study gene regulation during cellular differentiation (InteGeR)

Start date: Jan 1, 2009, End date: Dec 31, 2012,

Cellular differentiation from stem cells to fully functional mature cells is a multi step process executed by complex transcription programs. Once differentiated, cells must faithfully maintain their identity through cellular memory mechanisms. The utilisation of genetic information stored in linear DNA sequence occurs within the three dimensional context of chromatin, chromosomes and the nucleus, ...
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 9

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Enhancing BSRC Al. Fleming research potential in genomics and proteomics applications (GENPRO)

Start date: Dec 1, 2009, End date: Nov 30, 2012,

.... Fleming is the most rapidly developing research center in Greece. It started its operation under an interim administrative board in 1998 and develops research programs at the cutting edge of modern biomedical sciences. The aim of this project is to reinforce and enhance the scientific research potential of the BSRC Al. Fleming in the areas of functional genomics and proteomics. This aim stems fr ...
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 1

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Coordination of resources for conditional expression of mutated mouse alleles (CREATE)

Start date: Nov 1, 2008, End date: Oct 31, 2011,

"This proposal describes CREATE, an internationally based Coordination Action directly addressing a large scale data gathering activity for systematic conditional mouse mutagenesis. Advances in the sophisticated manipulation of the mouse genome has established the mouse as the premier organism for developing models of human disease. Internationally coordinated initiatives have established for the ...
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 8