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Searched on 125080 European Projects

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The role of non coding RNA in human health and disease (RNA_REGULOMICS)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

"RNA molecules have been already proven to be a key target for disease therapy as well as a tool for the development of new drugs. Since the discovery of small non coding RNA (ncRNA) and all the associated phenomena like RNA interference, the possibility of using RNA-based drugs has become a subject of great interest in the pharmaceutical and clinical fields. ncRNA is at the core of many cellular ...
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Embryonic stem (ES) cells are derived from the inner cell mass (ICM) of blastocyst-embryo stage. The potential of ES cells to differentiate in all kind of tissues, opens the possibility for future promising approaches, as genetic therapy and/or cell replacement, to treat many diseases, including type1 diabetes. Although several scientific groups have reported the successful differentiation of mous ...
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The presence of cellular cartilage-like tissues outside the chordate lineage is either indicative of a common origin of cartilage as a metazoan tissue type (homology), or alternatively highlights developmental and/or structural constraints in constructing an internal cellular support tissue or endoskeleton (convergence). If a genetic program for specifying chondrocytes (cartilage cells) arose only ...
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