2 European Projects Found
Searched on 125080 European Projects
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A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)
Start date: Oct 1, 2011, End date: Sep 30, 2016,
In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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Systematic Identification and Validation of Epigenetic Cancer Lesions by Chemical Biology and Functional Genomics (EPICAL)
Start date: Dec 1, 2011, End date: Nov 30, 2015,
Epigenetic pathways contribute to cancer development and progression. These pathways act via proteins that modulate chromatin structure and gene expression, and can thereby give pro-proliferative and anti-apoptotic properties selected for in cancer. In total ~400 factors are known that either modify chromatin directly as epigenetic ‘writers’ (DNA methyltranserases, histone methyltransferases, acet ...
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