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Establishing a mouse model for ICE Fever, a novel autoinflammatory syndrome associated with procaspase-1 mutations (Model for ICE fever)
Start date: Mar 1, 2008, End date: Feb 29, 2012,
In up to 80% of patients with symptoms of an autoinflammatory syndrome (periodic fever syndrome) a molecular diagnosis is currently not possible. Procaspase-1 (aka IL-1 converting enzyme, ICE) is a component of the CIAS1/NALP3 ‘inflammasome’ and plays critical roles in releasing the proinflammatory cytokine IL-1b. and regulating the NFkB-activating RIP-2 pathway. Sequencing of the procaspase-1 cod ...
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