3 European Projects Found
Searched on 125080 European Projects
FINISHED
A Phase Ib/II study of MEK1/2 inhibitor PD-0325901 or MEK-162 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients (MERCURIC)
Start date: Dec 1, 2013, End date: Nov 30, 2020,
Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omi ...
Read Project
13
Partners Participants
FINISHED
Pushing Myc inhibition towards the clinic (Mycinhibinclinic)
Start date: May 1, 2014, End date: Apr 30, 2019,
Deregulation of the Myc oncogene promotes tumorigenesis in most if not all cancers and is often associated with poor prognosis. However, targeting Myc has long been considered impossible because of potential catastrophic side effects in normal tissues. Despite this general assumption, we showed that Myc inhibition displays extraordinary therapeutic benefit in various transgenic mouse models of can ...
Read Project
2
Partners Participants
FINISHED
Molecular Mechanisms of Glioma Genesis and Progression (Glioma)
Start date: Aug 1, 2008, End date: Jul 31, 2014,
Glioma is the most common and aggressive tumour of the brain and its most malignant form, glioblastoma multiforme, is nowadays virtually not curable. Very little is known about glioma genesis and progression at the molecular level and not much progress has been achieved in the treatment of this disease during the last years. The understanding of the molecular mechanisms involved in the biology of ...
Read Project
