Search for European Projects

10 European Projects Found

Searched on 125080 European Projects

 FINISHED 

SIMVASTATIN AND RIFAXIMIN AS NEW THERAPY FOR PATIENTS WITH DECOMPENSATED CIRRHOSIS (LIVERHOPE)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Liver cirrhosis is a very common chronic disease and one of the leading causes of death in European. Moreover, cirrhosis has a marked impact in patients quality of life and represents a major burden for health systems. Treatment of cirrhosis is currently based on symptomatic management of complications and has not changed substantially in the last 20 years. There is an unmet need for therapies tha ...
Read Project

 18

 FINISHED 

Early warning signals of ageing in human stem cells and age-related disorders (SYSTEMAGE)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

The regenerative power of a living organism is linked to the potential of its stem cells to replace the corresponding damaged tissue. Therefore organisms are as old as their stem cells. Whereas the vulnerability to cancer and chronic inflammation is associated with a decline of the immune system, the latter is in turn a sum product of interactions among hematopoietic stem cells (HSC), endothelial ...
Read Project

 11

 FINISHED 

"King of hearts, joints and lungs; periodontal pathogens as etiologic factor in RA, CVD and COPD and their impact on treatment strategies." (TRIGGER)

Start date: Apr 1, 2013, End date: Mar 31, 2017,

"Extensive clinical and epidemiological data clearly shows that chronic periodontal disease (PD), the most prevalent infectious inflammatory disease of mankind, is strongly linked to systemic inflammatory diseases such as cardiovascular diseases (CVD) , rheumatoid arthritis (RA) , and chronic obstructive pulmonary disease (COPD) . Taking into account that up to 30% of the adult population worldwid ...
Read Project

 11

 FINISHED 

Optimized oxidoreductases for medium and large scale industrial biotransformations (INDOX)

Start date: Nov 1, 2013, End date: Oct 31, 2016,

The INDOX proposal on industrial oxidoreductases aims to provide relevant industrial case stories to demonstrate the efficacy of optimized biocatalysts on targeted reactions, and to establish the processes scalability, sustainability and cost-efficiency versus chemical conversion processes. The chemical industry (specialties excluded) is not yet embracing enzymatic oxidation reactions to a signifi ...
Read Project

 16

 FINISHED 

Prolonged inhibition of semaphorine3a pathway via a bio-degradable implant towards a better therapy for visual sensory impairments (VISION)

Start date: Sep 1, 2012, End date: Aug 31, 2016,

"The visual pathway is a component of the central nervous system (CNS) and therefore is not regenerative. Acute optic nerve injury, ischemic optic neuropathy and glaucoma are conditions that initially lead to partial blindness and eventually could lead to total blindness. Extensive neuron and retinal ganglion cells (RGC) death is evidenced in these pathologies. Semaphorin 3A (Sema3A) is a cell sec ...
Read Project

 5

 FINISHED 

Rheumatoid Arthritis and Periodontal Inflammatory Disease (RAPID) (RAPID)

Start date: Apr 1, 2012, End date: Mar 31, 2016,

"The most prevalent chronic inflammatory diseases of humans are complex disorders of multifactorial aetiology influenced by genes, the environment and their interactions. Periodontitis (PD) and rheumatoid arthritis (RA) are two such chronic inflammatory diseases associated withsignificant morbidity and mortality, and have recently shown to have a bi-directional association. Moreover, the prevalenc ...
Read Project

 15

 FINISHED 

Identifying correlates of protection to accelerate vaccine trials: systems evaluation of two models of experimentally-induced immunity to malaria (SysMalVac)

Start date: Jan 1, 2013, End date: Dec 31, 2014,

Vaccine development is an empirical process (trial and error) and involves a long, expensive clinical development pipeline to license an efficacious vaccine candidate. Better tools for vaccine evaluation are needed to adapt to a rising number of candidate vaccines entering clinical trials for many diseases. Surrogate biomarkers of immunity offer the possibility of expediting the clinical developme ...
Read Project

 8

 FINISHED 

A novel drug discovery method based on systems biology: combination therapy and biomarkers for Multiple Sclerosis (CombiMS)

Start date: Jan 1, 2013, End date: Dec 31, 2014,

The therapeutic challenge of complex diseases requires the use of combination therapies to target the distinct mechanisms and pathways involved. Such complex diseases will benefit from the design of computational models adopting a systems perspective to integrate the knowledge generated by ‘omics technologies and clinical data. Multiple Sclerosis is a prototypic debilitating complex disease in whi ...
Read Project

 8

 FINISHED 

Protein citrullination as a link between periodontal diseases and rheumatoid arthritis (RA) and target for development of novel drugs to treat RA (GUMS AND JOINTS)

Start date: Nov 1, 2010, End date: Oct 31, 2014,

Autoimmunity in rheumatoid arthritis (RA) is characterised by an antibody response to citrullinated proteins. Periodontitis (PD) is largely caused by infection, in whichPorphyromonas gingivalis is a major pathogen. The two diseases combine specific HLA-DRB1alleles and smoking as risk factors, and have a similar pathophysiology characterised by destructive inflammation. A possible causative link be ...
Read Project

 14

 FINISHED 

Identification and validation of novel drug targets in Gram-negative bacteria by global search: a trans-system approach (AntiPathoGN)

Start date: Feb 1, 2009, End date: Jul 31, 2013,

Multi-drug-resistant bacterial infections are increasing at an alarming pace in both developing and developed countries and in both community and nosocomial settings. The few antimicrobial agents that have been launched during the last decade (e.g. linezolid, daptomycin) have a good activity against Gram-positive bacteria. However, multi-drug-resistant bacteria are often found among the Gram-negat ...
Read Project

 11